TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE

Product Name: TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE
CAS No.: 211108-50-8
Chemical Name: TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE
Synonyms: 4-Boc-Piperidinone,3-fluoro;N-Boc-5-fluoro-4-piperidone;N-Boc-3-fluoro-4-piperidone;1-Boc-3-fluoro-4-piperidone;3-Fluoro-4-boc- Piperidinone;1-Boc-3-fluoropiperidin-4-one;1-Boc-3-fluoro-4-oxopiperidine;N-t-BOC-5-Fluoropiperidin-4-one;1-Boc-3-fluoro-4-piperidone,95%;1-Boc-3-fluoro-4-piperidone, 95%
CBNumber: CB01561757
Molecular Formula: C10H16FNO3
Formula Weight: 217.24
MOL File: 211108-50-8.mol

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TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE Property

Melting point:: 88-90℃
Boiling point:: 288.7±40.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: -3.61±0.40(Predicted)
color: White to Light yellow
InChI: InChI=1S/C10H16FNO3/c1-10(2,3)15-9(14)12-5-4-8(13)7(11)6-12/h7H,4-6H2,1-3H3
InChIKey: JZNWQLLPLOQGOI-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(=O)C(F)C1
CAS DataBase Reference: 211108-50-8

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Safety

Hazard Codes: Xi
Risk Statements: 36-52
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00094
Product name: tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate
Purity: Aldrich
Packaging: 1g
Price: $58.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 753394
Product name: 1-Boc-3-fluoro-4-oxopiperidine
Purity: 95%
Packaging: 250mg
Price: $147
Updated: 2023/06/20

TCI Chemical

Product number: B4858
Product name: 1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidone
Purity: >97.0%(GC)
Packaging: 200mg
Price: $107
Updated: 2025/07/31

TCI Chemical

Product number: B4858
Product name: 1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidone
Purity: >97.0%(GC)
Packaging: 1g
Price: $313
Updated: 2025/07/31

TRC

Product number: B809630
Product name: tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate
Packaging: 500mg
Price: $90
Updated: 2021/12/16

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TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE Chemical Properties,Usage,Production

Uses

Tert-Butyl 3-Fluoro-4-Oxopiperidine-1-Carboxylate is a versatile compound that finds frequent application in chemical synthesis procedures. This compound serves as a valuable building block due to its unique structural properties and reactivity. Within the realm of organic synthesis, Tert-Butyl 3-Fluoro-4-Oxopiperidine-1-Carboxylate is commonly used as a key intermediate in the preparation of various pharmaceuticals, agrochemicals, and fine chemicals.
This compound undergoes a variety of selective reactions, enabling chemists to introduce functional groups at specific positions on the piperidine ring. Its tert-butyl ester group provides steric hindrance, influencing the compound's reactivity and selectivity in subsequent transformations. Additionally, the presence of a fluoro substituent enhances the compound's electronic properties, enabling it to participate in diverse synthetic strategies.Researchers leverage the unique structural features of Tert-Butyl 3-Fluoro-4-Oxopiperidine-1-Carboxylate to access complex molecular architectures efficiently. By incorporating this compound into their synthetic routes, chemists can streamline the synthesis of intricate molecules and accelerate the discovery of novel bioactive compounds. In summary, the versatile nature of Tert-Butyl 3-Fluoro-4-Oxopiperidine-1-Carboxylate makes it an indispensable tool in modern chemical synthesis endeavors.

Synthesis

211108-48-4

211108-50-8

Tert-butyl 4-(trimethylsilyloxy)-5,6-dihydropyridine-1(2H)-carboxylate (25.0 g, 0.09 mol) was used as a raw material, which was dissolved in anhydrous acetonitrile (200 mL), and 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane ditetrafluoroborate (35.8 g, 0.101 mol) was added under stirring. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction solution was diluted with ethyl acetate and subsequently washed with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel fast column chromatography to afford tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate as an off-white solid in 73% yield (8.1 g). The product was analyzed by LCMS (Method C): m/z 118.2 (M-Boc + H), retention time 2.53 min, purity 96.5% (ELSD).1H NMR (400 MHz, DMSO-d6) δ: 4.92-4.89 (m, 1H), 4.76-4.73 (m, 1H), 4.21-4.17 (m, 1H). 3.30-3.20 (m, 2H), 2.60-2.45 (m, 2H), 1.47 (s, 9H).

References

[1] Patent: WO2008/124323, 2008, A1. Location in patent: Page/Page column 40
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 15, p. 2667 - 2670
[3] Journal of Medicinal Chemistry, 1999, vol. 42, # 12, p. 2087 - 2104
[4] Patent: WO2013/96744, 2013, A1. Location in patent: Page/Page column 223
[5] Patent: US2006/258721, 2006, A1. Location in patent: Page/Page column 74; 75

TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE Suppliers

Americas 1 Canada 1 China 173 Europe 1 Germany 1 India 4 Japan 1 United Kingdom 2 United States 17 Global 201

Shanghai AQBioPharma Co., Ltd.

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View Lastest Price from TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate 211108-50-8
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-27

Changsha YuTeng New Materials Co., Ltd.

Product: TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE 211108-50-8
Price: US $0.00-0.00/g
Min. Order: 100g
Purity: 97%
Supply Ability: 500kg/M
Release date: 2024-11-08

Henan Aochuang Chemical Co.,Ltd.

Product: TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE 211108-50-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

211108-50-8, TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATERelated Search:

tert-butyl 2-formylpropan-2-ylcarbamate TERT-BUTYL 1-OXO-2,7-DIAZASPIRO[4.5]DECANE-7-CARBOXYLATE H2N-PEG1-CH2COOtBu Haloperidol 4-PHENYL-4-PIPERIDINE CARBOXYLIC ACID L-Pipecolic acid hydrochloride TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE 3-FLUOROPIPERIDINE

TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE

4-Boc-Piperidinone,3-fluoro

3-Fluoro-4-boc- Piperidinone

tert-Butyl 3-fluoro-4-oxopiperidin-1-carboxylate

3-Fluoro-4-oxopiperidine-1-carboxylic acid tert-butyl ester

N-t-BOC-5-Fluoropiperidin-4-one

3-Fluoropiperidin-4-one, N-BOC protected

tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-fluoro-4-oxopiperidine

tert-butyl 3-fluoro-4-oxopiperidine-1-carbo×ylate

1-Piperidinecarboxylic acid, 3-fluoro-4-oxo-, 1,1-diMethylethyl ester

1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidone

1-Boc-3-fluoro-4-oxopiperidine

1-Boc-3-fluoro-4-piperidone, 95%

1-Boc-3-fluoropiperidin-4-one

N-Boc-5-fluoro-4-piperidone

3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLIC ACID TE RT-BUTYL ESTER,97%

1-Boc-3-fluoro-4-piperidone,95%

tertbutylfluorooxopiperidinecarboxylate

3-Fluoro-4-oxo-1-piperidinecarboxylic Acid tert-Butyl Ester

tert-Butyl 3-Fluoro-4-oxo-1-piperidinecarboxylate

tert-butyl 3-fluoro-4-oxopiperdine-1-carboxylate

1,1-Dimethylethyl 3-fluoro-4-oxo-1-piperidinecarboxylate

N-Boc-3-fluoro-4-piperidone

1-Boc-3-fluoro-4-oxopiperidine/211108-50-8/95%

1-Boc-3-fluoro-4-piperidone

211108-50-8

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