2-bromothiazole-5-carbonitrile
- Product Name
- 2-bromothiazole-5-carbonitrile
- CAS No.
- 440100-94-7
- Chemical Name
- 2-bromothiazole-5-carbonitrile
- Synonyms
- 2-Bromo-5-cyanothiazole;2-bromothiazole-5-carbonitrile;2-BroMo-5-thiazolecarbonitrile;5-Thiazolecarbonitrile, 2-bromo-;2-broMo-1,3-thiazole-5-carbonitrile
- CBNumber
- CB01563812
- Molecular Formula
- C4HBrN2S
- Formula Weight
- 189.03
- MOL File
- 440100-94-7.mol
2-bromothiazole-5-carbonitrile Property
- Boiling point:
- 276.1±13.0 °C(Predicted)
- Density
- 1.97±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.28±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C4HBrN2S/c5-4-7-2-3(1-6)8-4/h2H
- InChIKey
- RCVDPJMWWCIVJV-UHFFFAOYSA-N
- SMILES
- S1C(C#N)=CN=C1Br
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B683378
- Product name
- 2-Bromo-5-cyanothiazole
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- P000114286
- Product name
- 2-Bromothiazole-5-carbonitrile
- Purity
- 98%
- Packaging
- 250mg
- Price
- $42
- Updated
- 2021/12/16
- Product number
- FB154175
- Product name
- 2-Bromo-5-cyanothiazole
- Packaging
- 250mg
- Price
- $57.5
- Updated
- 2021/12/16
- Product number
- P000114286
- Product name
- 2-Bromothiazole-5-carbonitrile
- Purity
- 98%
- Packaging
- 1g
- Price
- $79
- Updated
- 2021/12/16
- Product number
- CS-W005651
- Product name
- 2-Bromothiazole-5-carbonitrile
- Purity
- ≥97.0%
- Packaging
- 1g
- Price
- $81
- Updated
- 2021/12/16
2-bromothiazole-5-carbonitrile Chemical Properties,Usage,Production
Synthesis
51640-52-9
440100-94-7
General procedure for the synthesis of 2-bromo-5-cyano thiazole from 2-amino-5-cyano thiazole: (1) Preparation of 2-bromo-5-cyano thiazole: 2-amino-5-cyano thiazole (875 mg, 7.00 mmol) prepared according to the method described in the unexamined disclosure of the Japanese Patent (KOKAI) No. 9-169,748, was dissolved in 47% hydrobromic acid (14 mL) and a water in a mixed solution (14 mL). An aqueous solution of sodium nitrite (580 mg, 8.40 mmol) was added slowly and dropwise (7 mL) to this solution under ice bath cooling conditions. The reaction mixture was stirred at the same temperature for 5 min and then warmed up to 50 °C and continued stirring for 6 h. The reaction was carried out at the same temperature. After completion of the reaction, ethyl acetate was added to the mixture for extraction, and the organic layer was washed sequentially with water, saturated aqueous sodium bicarbonate solution and saturated saline. The organic layer was dried over anhydrous magnesium sulfate and the solvent was concentrated under reduced pressure to give 2-bromo-5-cyanothiazole (1.05 g, 5.56 mmol) as an orange solid in 79% yield.1H NMR (DMSO-d6) δ (ppm): 8.57 (1H, s).
References
[1] Patent: EP1354882, 2003, A1. Location in patent: Page/Page column 71-72
2-bromothiazole-5-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-bromothiazole-5-carbonitrile manufacturers
- Product
- 2-bromothiazole-5-carbonitrile 440100-94-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-23