6-chloro-4-methyl-2H-pyridazin-3-one
- Product Name
- 6-chloro-4-methyl-2H-pyridazin-3-one
- CAS No.
- 1834-27-1
- Chemical Name
- 6-chloro-4-methyl-2H-pyridazin-3-one
- Synonyms
- 6-chloro-4-methylpyridazin-3-ol;3-chloro-5-methyl-1H-pyridazin-6-one;6-Chloro-4-Methylpyridazin-3(2H)-one;6-chloro-4-methyl-2H-pyridazin-3-one;6-Chloro-3-hydroxy-4-methylpyridazine;3(2H)-Pyridazinone, 6-chloro-4-Methyl-;6-CHLORO-4-METHYL-2H-PYRIDAZIN-3（2H）-ONE;6-chloro-4-methyl-2,3-dihydropyridazin-3-one;6-chloro-4-methyl-2H-pyridazin-3-one ISO 9001：2015 REACH;6-Chloro-4-methylpyridazin-3-ol, 6-Chloro-3-hydroxy-4-methyl-1,2-diazine
- CBNumber
- CB01563993
- Molecular Formula
- C5H5ClN2O
- Formula Weight
- 144.56
- MOL File
- 1834-27-1.mol
6-chloro-4-methyl-2H-pyridazin-3-one Property
- Melting point:
- 149-151 °C
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 9.84±0.60(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C5H5ClN2O/c1-3-2-4(6)7-8-5(3)9/h2H,1H3,(H,8,9)
- InChIKey
- VCFUTDUJFGHTKM-UHFFFAOYSA-N
- SMILES
- C1(=O)NN=C(Cl)C=C1C
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 4H56-5-G4
- Product name
- 6-Chloro-3-hydroxy-4-methylpyridazine
- Packaging
- 1g
- Price
- $136
- Updated
- 2021/12/16
- Product number
- 4H56-5-G4
- Product name
- 6-Chloro-3-hydroxy-4-methylpyridazine
- Packaging
- 5G
- Price
- $416
- Updated
- 2021/12/16
- Product number
- HCH0367963
- Product name
- 6-CHLORO-4-METHYLPYRIDAZIN-3(2H)-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.15
- Updated
- 2021/12/16
- Product number
- Z4322
- Product name
- 6-Chloro-4-methylpyridazin-3(2H)-one
- Packaging
- 25g
- Price
- $980
- Updated
- 2021/12/16
- Product number
- A159171
- Product name
- 6-Chloro-4-methylpyridazin-3(2H)-one
- Purity
- 97+%
- Packaging
- 100mg
- Price
- $18
- Updated
- 2021/12/16
6-chloro-4-methyl-2H-pyridazin-3-one Chemical Properties,Usage,Production
Synthesis
89466-38-6
1834-27-1
The general procedure for the synthesis of 6-chloro-4-methyl-3-pyridazinone from 3-methoxy-4-methyl-6-chloropyridazine was as follows: 6-chloro-3-methoxy-4-methylpyridazine (3.31 g, 20.9 mmol) was dissolved in a 4:1 solvent mixture of dioxane and water (100 mL), and 12.0 M aqueous hydrochloric acid (1.91 mL, 23.0 mmol ), and the reaction was stirred at 60°C for 60 hours. After completion of the reaction, the reaction mixture was concentrated in vacuum, and the crude product obtained was purified by silica gel column chromatography with an elution gradient of 1-30% of a solvent mixture of dichloromethane and methanol (containing 2% of ammonia as an additive) to finally obtain 6-chloro-4-methyl-3-pyridazinone (2.99 g, 99% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6) with chemical shifts of 13.03 (s, 1H), 7.44 (s, 1H), 2.05 (s, 3H).
References
[1] Patent: WO2017/70708, 2017, A1. Location in patent: Paragraph 00548; 00549; 00550; 00552
[2] Yakugaku Zasshi, 1962, vol. 82, p. 1005,1009
[3] Chem.Abstr., 1963, vol. 58, # 4559,
[4] Yakugaku Zasshi, 1962, vol. 82, p. 304,307
[5] Chem.Abstr., 1963, vol. 58, # 3427,
6-chloro-4-methyl-2H-pyridazin-3-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-chloro-4-methyl-2H-pyridazin-3-one manufacturers
- Product
- 6-chloro-4-methyl-2H-pyridazin-3-one 1834-27-1
- Price
- US $0.00-0.00/G
- Min. Order
- 1G
- Purity
- 99%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-09-11
- Product
- 6-chloro-4-methyl-2H-pyridazin-3-one 1834-27-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-02
- Product
- 6-chloro-4-methyl-2H-pyridazin-3-one 1834-27-1
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 98%min
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20