6,7-difluorochroman-4-one
- Product Name
- 6,7-difluorochroman-4-one
- CAS No.
- 1092349-93-3
- Chemical Name
- 6,7-difluorochroman-4-one
- Synonyms
- EOS-61820;6,7-difluorochroman-4-one;6,7-Difluro-2,3-dihydro-4H-1-benzopyranone;6,7-Difluoro-2,3-dihydro-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 6,7-difluoro-2,3-dihydro-
- CBNumber
- CB01570713
- Molecular Formula
- C9H6F2O2
- Formula Weight
- 184.14
- MOL File
- 1092349-93-3.mol
6,7-difluorochroman-4-one Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light brown to brown Solid
Safety
- HS Code
- 2932990090
N-Bromosuccinimide Price
- Product number
- D447883
- Product name
- 6,7-Difluorochroman-4-one
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 5544DM
- Product name
- 6,7-Difluorochroman-4-one
- Packaging
- 250mg
- Price
- $158
- Updated
- 2021/12/16
- Product number
- PC907037
- Product name
- 6,7-Difluorochroman-4-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $345
- Updated
- 2021/12/16
- Product number
- 2H17-3-0K
- Product name
- 6,7-Difluorochroman-4-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $552
- Updated
- 2021/12/16
- Product number
- 1092349933
- Product name
- 6,7-Difluorochroman-4-one
- Packaging
- 25g
- Price
- $1572
- Updated
- 2021/12/16
6,7-difluorochroman-4-one Chemical Properties,Usage,Production
Synthesis
926256-60-2
1092349-93-3
Step 2: 3-(3,4-difluorophenoxy)propionic acid (0.50 g, 2.5 mmol) was mixed with trifluoromethanesulfonic acid (5.0 mL, 56 mmol) and the reaction was stirred at room temperature for 18 hours. Upon completion of the reaction, the mixture was slowly poured into ice water (30 mL) to quench the reaction. The precipitated solid was collected by filtration to afford the target product 6,7-difluorobenzodihydropyran-4-one (370 mg, 81% yield) as a white solid. Mass spectrometric analysis showed m/z 185 [M + H]+ (electrospray ionization) with a retention time of 1.76 min (Analytical Method 1).
References
[1] Tetrahedron Letters, 2010, vol. 51, # 48, p. 6236 - 6239
[2] Patent: WO2016/142867, 2016, A1. Location in patent: Page/Page column 59; 60
[3] Tetrahedron Letters, 2010, vol. 51, # 48, p. 6236 - 6239
6,7-difluorochroman-4-one Preparation Products And Raw materials
Raw materials
Preparation Products
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