ChemicalBook > CAS DataBase List > 2-CHLORO-6-METHOXY-QUINOLINE

2-CHLORO-6-METHOXY-QUINOLINE

Product Name: 2-CHLORO-6-METHOXY-QUINOLINE
CAS No.: 13676-02-3
Chemical Name: 2-CHLORO-6-METHOXY-QUINOLINE
Synonyms: Einecs 237-162-9;2-CHLORO-6-METHOXY-QUINOLINE;6-METHOXY-2-CHLORO-QUINOLINE;Quinoline, 2-chloro-6-methoxy-;2-Chloro-6-methoxy-1-azanaphthalene
CBNumber: CB0162238
Molecular Formula: C10H8ClNO
Formula Weight: 193.63
MOL File: 13676-02-3.mol

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2-CHLORO-6-METHOXY-QUINOLINE Property

Melting point:: 106-107℃
Boiling point:: 310.5±22.0 °C(Predicted)
Density: 1.267
storage temp.: Inert atmosphere,Room Temperature
pka: 0.37±0.43(Predicted)
form: solid
Appearance: White to yellow Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 3
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BBO000233
Product name: 2-Chloro-6-methoxyquinoline
Purity: Aldrich
Packaging: 1g
Price: $286
Updated: 2025/07/31

TRC

Product number: C368593
Product name: 2-Chloro-6-methoxyquinoline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: C368593
Product name: 2-Chloro-6-methoxyquinoline
Packaging: 500mg
Price: $110
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-5-5P
Product name: 2-Chloro-6-methoxyquinoline
Packaging: 1g
Price: $288
Updated: 2021/12/16

Apolloscientific

Product number: OR307500
Product name: 2-Chloro-6-methoxyquinoline
Packaging: 1g
Price: $261
Updated: 2021/12/16

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2-CHLORO-6-METHOXY-QUINOLINE Chemical Properties,Usage,Production

Synthesis

13676-00-1

13676-02-3

General procedure for the synthesis of 2-chloro-6-methoxyquinoline from 6-methoxyquinolin-2(1H)-one: 6-methoxyquinolin-2-ol (400 mg, 2.29 mmol) was dissolved in phosphorus trichloride (5.0 mL) and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (50 mL) and the organic layer was washed sequentially with saturated sodium bicarbonate solution (30 mL × 2). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 10:1) to afford 2-chloro-6-methoxyquinoline (380 mg, 86% yield) as a white solid.1H NMR (CDCl3, 400 MHz): δ 7.92 (d, J = 8.4 Hz, 1H), 7.85 (d, J = 9.2 Hz, 1H), 7.32-7.25 ( m, 2H), 7.00 (d, J = 2.4 Hz, 1H), 3.86 (s, 3H).

References

[1] Patent: WO2012/48181, 2012, A1. Location in patent: Page/Page column 74
[2] Patent: WO2012/83165, 2012, A1. Location in patent: Page/Page column 91
[3] Ann. Inst. Pasteur, 1930, vol. 44, p. 719,736

2-CHLORO-6-METHOXY-QUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-6-METHOXY-QUINOLINE Suppliers

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View Lastest Price from 2-CHLORO-6-METHOXY-QUINOLINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Chloro-6-methoxyquinoline 13676-02-3
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

R&D Scientific Inc.

Product: 2-chloro-6-methoxyquinoline 13676-02-3
Price: US $2800.00/g
Min. Order: 1g
Purity: 99 %
Supply Ability: 5000 Kg
Release date: 2025-06-26

Career Henan Chemical Co

Product: 2-CHLORO-6-METHOXY-QUINOLINE 13676-02-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200KG
Release date: 2018-12-23

13676-02-3, 2-CHLORO-6-METHOXY-QUINOLINERelated Search:

2-CHLORO-6-METHOXYQUINOLINE-3-CARBALDEHYDE 2-CHLORO-6-METHOXY-QUINOLINE 6-Methoxyquinoline 2-CHLORO-6-METHOXYQUINOLINE-3-CARBONITRILE 2-CHLORO-5,6,7-TRIMETHOXY-QUINOLINE-3-CARBALDEHYDE 2-CHLORO-6-METHOXY-3-METHYL-QUINOLINE 6-CHLORO-[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBALDEHYDE 2-CHLORO-6-METHOXY-QUINOLINE-3-CARBOXYLIC ACID 2,6-DIMETHOXY-4-METHYLQUINOLINE 2-CHLORO-6-METHOXYQUINOLINE-3-METHANOL 2-CHLORO-6-(ETHYLOXY)QUINOLINE-3-CARBALDEHYDE 2-CHLORO-6-ETHOXYQUINOLINE-3-METHANOL 2-CHLORO-7-METHOXY-QUINOLINE-3-CARBOXYLIC ACID 2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE 2-CHLORO-6-METHOXY-QUINOLINE-3-CARBALDEHYDE OXIME 2-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBALDEHYDE 7-CHLORO-4-METHOXY-QUINOLINE-3-CARBOXYLIC ACID 4-CHLORO-8-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Einecs 237-162-9

Quinoline, 2-chloro-6-methoxy-

2-Chloro-6-methoxy-1-azanaphthalene

6-METHOXY-2-CHLORO-QUINOLINE

2-CHLORO-6-METHOXY-QUINOLINE

13676-02-3