DIETHYL 2,5-DIOXOBICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLATE

DIETHYL 2,5-DIOXOBICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLATE Property

Melting point:

111 °C

Boiling point:

393.0±42.0 °C(Predicted)

Density 

1.320±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

Appearance

Off-white to light yellow Solid

CAS DataBase Reference

843-59-4

Safety

Hazard Codes 

Xi

Hazard Note 

Irritant

HS Code 

2917200090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

DIETHYL 2,5-DIOXOBICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLATE Chemical Properties,Usage,Production

Synthesis

In a 250 mL four-neck flask equipped with a mechanical stirrer, thermometer, dropping funnel and condenser tube, 9.6 g (0.28 mol) of sodium hydride was suspended in 80 mL of ethylene glycol dimethyl ether. Subsequently, 25.6 g (0.1 mol) of diethyl 2,5-dioxocyclohexane-1,4-dicarboxylate was added successively to the suspension. At 60 °C, 86.8 g (0.46 mol) of 1,2-dibromoethane was slowly added dropwise. After the dropwise addition, the reaction temperature was raised to 90 °C and the reaction was continued with stirring for 20 h. Upon completion of the reaction, the unreacted 1,2-dibromoethane and the ethylene glycol dimethyl ether solvent were removed by distillation under reduced pressure. The residue was dissolved in a large amount of dichloromethane and the remaining solid was adjusted to weak acidity (pH ≈ 5-6) with concentrated hydrochloric acid. Subsequently, extraction with dichloromethane was carried out to combine the organic phases and remove the solvent. The crude product was purified by recrystallization from ethanol to afford diethyl 2,5-dioxobicyclo[2.2.2]octane-1,4-dicarboxylate in 95% purity and 50% yield.

References

[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 10, p. 3480 - 3491
[2] Journal of the American Chemical Society, 2008, vol. 130, # 24, p. 7659 - 7669
[3] Patent: CN101768074, 2017, B. Location in patent: Paragraph 0005; 0019; 0022
[4] Canadian Journal of Chemistry, 1964, vol. 42, p. 2852 - 2861
[5] Journal of the American Chemical Society, 2011, vol. 133, # 10, p. 3570 - 3581