4-IODOPYRIDINE-2-CARBOXYLIC ACID
- Product Name
- 4-IODOPYRIDINE-2-CARBOXYLIC ACID
- CAS No.
- 405939-79-9
- Chemical Name
- 4-IODOPYRIDINE-2-CARBOXYLIC ACID
- Synonyms
- AKOS BBS-00006014;4-Iodopicolinicaci;IFLAB-BB F1926-0015;4-IODOPICOLINIC ACID;4-IODOPYRIDINE-2-CARBOXYLIC ACID;4-IODO-2-PYRIDINECARBOXYLIC ACID;2-Pyridinecarboxylic acid, 4-iodo-;4-4-Iodopyridine-2-carboxylic acid;4-Iodopyridine-2-carboxylic acid 96%;4-Iodopyridine-2-carboxylic acid ,97%
- CBNumber
- CB0172716
- Molecular Formula
- C6H4INO2
- Formula Weight
- 249.01
- MOL File
- 405939-79-9.mol
4-IODOPYRIDINE-2-CARBOXYLIC ACID Property
- Melting point:
- 164-166
- Boiling point:
- 376.2±27.0 °C(Predicted)
- Density
- 2.123±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- form
- solid
- pka
- 3.29±0.10(Predicted)
- color
- Red
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36-37/38/39
- Safety Statements
- 26-36/37/39
- Hazard Note
- Irritant
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I718820
- Product name
- 4-Iodopicolinicacid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 280958
- Product name
- 4-Iodopyridine-2-carboxylic acid
- Packaging
- 500mg
- Price
- $347
- Updated
- 2021/12/16
- Product number
- 069900
- Product name
- 4-Iodopyridine-2-carboxylic acid
- Purity
- 98%
- Packaging
- 10g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 4H21-H-X0
- Product name
- 4-Iodopyridine-2-carboxylic acid
- Purity
- 97%
- Packaging
- 5G
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 4H21-H-X0
- Product name
- 4-Iodopyridine-2-carboxylic acid
- Purity
- 97%
- Packaging
- 500mg
- Price
- $29
- Updated
- 2021/12/16
4-IODOPYRIDINE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Chemical Properties
White power
Synthesis
24484-93-3
405939-79-9
Methyl 4-chloropyridinecarboxylate (CYD-1-1, 4.8 g, 27.9 mmol) was mixed with 57% hydriodic acid (26.6 mL, 232.2 mmol) and 50% aqueous hypophosphorous acid (1.32 mL, 12.0 mmol), and the reaction was stirred for 2 hr at 85 °C, and then warmed up to 107 °C to continue the reaction overnight. Upon completion of the reaction, the mixture was cooled to 95 °C and 8.4 mL of 10N aqueous sodium hydroxide solution was slowly added. The mixture was continued to cool to room temperature and stirred for 1 h. A yellow solid was precipitated. After filtration, washing with cold water and vacuum drying overnight, 4-iodopyridinecarboxylic acid (6.8 g, 89% yield) was obtained. The resulting 4-iodopyridinecarboxylic acid (6.73 g, 27.0 mmol) was dissolved in methanol (101 mL), concentrated sulfuric acid (508 μL) was added, and the reaction was refluxed at 80 °C for 2 days. After completion of the reaction, the solvent was evaporated and the residue was dissolved in saturated sodium bicarbonate solution and extracted with ethyl acetate (3 times). The organic layers were combined, washed with saturated brine, dried over anhydrous Na2SO4 and the solvent evaporated. The residue was purified by silica gel column chromatography with 1:3 ethyl acetate-hexane as eluent to afford methyl 4-iodopyridinecarboxylate (CYD-1-4, 2.88 g, 40% overall yield in two steps) as a yellow solid with a melting point of 73-74 °C.1H NMR (600 MHz, CDCl3) δ 8.50 (d, 1H, J=1.2 Hz), 8.39 (d, 1H, J = 5.4 Hz), 7.87 (dd, 1H, J = 1.8 Hz and 4.8 Hz), 4.02 (s, 3H).
References
[1] Patent: WO2013/86266, 2013, A2. Location in patent: Paragraph 00092
[2] Patent: US9533973, 2017, B2. Location in patent: Page/Page column 34-35
[3] Patent: WO2004/16632, 2004, A2. Location in patent: Page 57-58
4-IODOPYRIDINE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-IODOPYRIDINE-2-CARBOXYLIC ACID manufacturers
- Product
- 4-iodopyridine-2-carboxylic acid 405939-79-9
- Price
- US $1.10-9.90/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- 4-IODOPYRIDINE-2-CARBOXYLIC ACID 405939-79-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01
- Product
- 4-IODOPYRIDINE-2-CARBOXYLIC ACID 405939-79-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23