(2R)-(-)-1-BENZOYL-2-TERT-BUTYL-3-METHYL-4-IMIDAZOLIDINONE Property

Melting point:

144-147°C

Boiling point:

425.3±38.0 °C(Predicted)

Density 

1.128±0.06 g/cm3(Predicted)

storage temp. 

Store below +30°C.

pka

-0.70±0.40(Predicted)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

WGK 3 highly water endangering

HS Code 

2933 29 90

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

(2R)-(-)-1-BENZOYL-2-TERT-BUTYL-3-METHYL-4-IMIDAZOLIDINONE Chemical Properties,Usage,Production

Purification Methods

Recrystallise these chiral imidazolinones from boiling EtOH (solubility is 1.43g/mL) or better by dissolving in CH2Cl2 and adding pentane, filtering and drying for at least 12hours at 60o/0.1mm and sublime them at 135o/0.01mm. They have also been purified by flash column chromatography through Merck silica gel at 0.04-0.063mm and using Et2O/pet ether/MeOH (60:35:5) as eluent. They are then recrystallised from EtOH/pet ether. [IR, NMR: Seebach et al. Helv Chim Acta 70 237 1987, Fitzi & Seebach Angew Chem, Int Ed Engl 25 345 1986.] The racemate is purified in a similar manner and has m 104-105o [NMR: Seebach et al. Helv Chim Acta 68 949 1985].