posizolid
- Product Name
- posizolid
- CAS No.
- 252260-02-9
- Chemical Name
- posizolid
- Synonyms
- AZD2563;AZD5847;posizoli;AZD 5847;AZD 2563;AZD-2563;AZD-5847;posizolid;Posizolid-13C2D4;AZD-2563, Posizolid
- CBNumber
- CB01856064
- Molecular Formula
- C21H21F2N3O7
- Formula Weight
- 465.407
- MOL File
- 252260-02-9.mol
posizolid Property
- Boiling point:
- 724.5±60.0 °C(Predicted)
- Density
- 1.491
- pka
- 12.79±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
posizolid Chemical Properties,Usage,Production
Uses
Posizolid (AZD2563), an oxazolidinone antibiotic, is developed by AstraZeneca for the study of bacterial infections. Posizolid shows very good anti-mycobacterial activity[1].
in vivo
AZD5847 DSP (AZD2563 is prodrug) could not be detected in plasma 5 min after oral administration, suggesting rapid conversion of the prodrug to the parent molecule.
In PK analysis, AZD5847(5 mg/kg) shows a low clearance (4.7 ml/min/kg) and volume of distribution (0.5 liter/kg) in mice, the half-life is 1.3 h[3].
| Animal Model: | Male BALB/c mice, aged 6 to 8 weeks, 30 to 40 g[3]. |
| Dosage: | 3, 10, 30, 100, 300, 600, and 900 mg/kg |
| Administration: | oral; collect blood samples at 5 min, 10 min, 15 min, 30 min, 1 h, 2 h, 4 h, 6 h, and 24 h |
| Result: | AZD5847 DSP can’t be detected in plasma 5 min. |
| Animal Model: | Male BALB/c mice, aged 6 to 8 weeks, 30 to 40 g[3]. |
| Dosage: | 250 mg/kg |
| Administration: | oral; collect blood and BAL fluid samples at 5 min, 15 min, 30 min, 1 h, 2 h, 4 h, 8 h, 16 h, 24 h, and 48 h |
| Result: | AZD5847(5 mg/kg) shows a low clearance (4.7 ml/min/kg) and volume of distribution (0.5 liter/kg) in mice, the half-life is 1.3 h. |
IC 50
Oxazolidinone
References
[1] Kumar D, et al. The anti-tuberculosis agents under development and the challenges ahead. Future Med Chem. 2015;7(15):1981-2003. DOI:10.4155/fmc.15.128
[2] Baum SE, et al. Comparative activities of the oxazolidinone AZD2563 and linezolid against selected recent North American isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother. 2002;46(9):3094-3095. DOI:10.1128/AAC.46.9.3094-3095.2002
[3] Balasubramanian V, et al. Pharmacokinetic and pharmacodynamic evaluation of AZD5847 in a mouse model of tuberculosis. Antimicrob Agents Chemother. 2014;58(7):4185-4190. DOI:10.1128/AAC.00137-14
posizolid Preparation Products And Raw materials
Raw materials
Preparation Products
posizolid Suppliers
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View Lastest Price from posizolid manufacturers
- Product
- posizolid 252260-02-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-27