4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole

Product Name: 4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole
CAS No.: 1029413-53-3
Chemical Name: 4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole
Synonyms: 4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole;tert-butyl3-(4-amino-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 3-(4-amino-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester
CBNumber: CB01856448
Molecular Formula: C12H20N4O2
Formula Weight: 252.31
MOL File: 1029413-53-3.mol

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4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole Property

Boiling point:: 412.9±35.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 4.29±0.19(Predicted)
Appearance: Brown to red Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: A594070
Product name: 4-Amino-1-(1-boc-pyrrolidin-3-yl)-1H-pyrazole
Packaging: 100mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0095072
Product name: 4-AMINO-1-(1-BOC-PYRROLIDIN-3-YL)-1H-PYRAZOLE
Purity: 95.00%
Packaging: 1G
Price: $1241.86
Updated: 2021/12/16

AK Scientific

Product number: 6607DG
Product name: Tert-butyl3-(4-amino-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate
Packaging: 250mg
Price: $130
Updated: 2021/12/16

Chemenu

Product number: CM247397
Product name: tert-Butyl3-(4-amino-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate
Purity: 95+%
Packaging: 1g
Price: $211
Updated: 2021/12/16

AstaTech

Product number: 52117
Product name: 4-AMINO-1-(1-BOC-PYRROLIDIN-3-YL)-1H-PYRAZOLE
Purity: 97%
Packaging: 5/ G
Price: $395
Updated: 2021/12/16

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4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole Chemical Properties,Usage,Production

Uses

4-Amino-1-(1-boc-pyrrolidin-3-yl)-1h-pyrazole is a pyrazolamine derivative that can be prepared by alkylation of nitropyrazole with alcohol and subsequent reduction.

Synthesis

1056024-38-4

1029413-53-3

(Step 3) Synthesis of tert-butyl 3-(4-amino-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate:[0490] 3-(4-nitro-1H-pyrazol-1-yl)pyrrolidine-1-carboxylic acid tert-butyl ester (1.25 g, 4.43 mmol) was suspended in ethanol (EtOH, 30.0 mL) and 10% palladium/carbon (Pd/C, 0.30 g) was added. The reaction mixture was stirred overnight at room temperature under hydrogen atmosphere. Upon completion of the reaction, the mixture was filtered and the filter cake was washed with methanol (MeOH, 10.0 mL). The filtrates were combined and concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography with a gradient of dichloromethane (DCM) to DCM/methanol (methanol solution containing 3M ammonia) as eluent (v/v=100/1 to 50/1) to afford the title compound as a brown viscous liquid (0.65 g, 58% yield). m/z MS (ESI, positive ion mode): 253.2 [M+H ]+; 1H NMR (400 MHz, CDCl3) δ (ppm): 7.16 (s, 1H), 7.01 (s, 1H), 4.79-4.67 (m, 1H), 3.82-3.73 (m, 1H), 3.70-3.44 (m, 3H), 2.90 (s, 2H), 2.36-2.24 (m, 2H), 1.45 (s, 9H).

References

[1] Tetrahedron Letters, 2008, vol. 49, # 18, p. 2996 - 2998
[2] Patent: WO2017/44434, 2017, A1. Location in patent: Paragraph 0490
[3] Patent: CN106478607, 2017, A. Location in patent: Paragraph 1043; 1044; 1045; 1046

4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole Suppliers

China 25 India 1 United States 4 Global 30

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1029413-53-3, 4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazoleRelated Search:

Pyrazole

4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole

tert-butyl3-(4-amino-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate

1-Pyrrolidinecarboxylic acid, 3-(4-amino-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester

1029413-53-3