2-Thiazolamine, 5-(1-methylethyl)-
- Product Name
- 2-Thiazolamine, 5-(1-methylethyl)-
- CAS No.
- 101080-15-3
- Chemical Name
- 2-Thiazolamine, 5-(1-methylethyl)-
- Synonyms
- 5-Isopropylthiazol-2-aMine;2-Amino-5-isopropylthiazole;2-Amino-5-isopropy-thiazole;5-Isopropyl-thiazol-2-ylaMine;5-isopropyl-1,3-thiazol-2-amine;5-(propan-2-yl)-1,3-thiazol-2-amine;2-Thiazolamine, 5-(1-methylethyl)-
- CBNumber
- CB01862685
- Molecular Formula
- C6H10N2S
- Formula Weight
- 142.22
- MOL File
- 101080-15-3.mol
2-Thiazolamine, 5-(1-methylethyl)- Property
- Boiling point:
- 110-115 °C(Press: 5 Torr)
- Density
- 1.142±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 5.32±0.10(Predicted)
- Appearance
- Light yellow to yellow Liquid
- InChI
- InChI=1S/C6H10N2S/c1-4(2)5-3-8-6(7)9-5/h3-4H,1-2H3,(H2,7,8)
- InChIKey
- MENMPXBUKLPJKR-UHFFFAOYSA-N
- SMILES
- S1C(C(C)C)=CN=C1N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I874468
- Product name
- 5-Isopropylthiazol-2-amine
- Packaging
- 100mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- FA148152
- Product name
- 2-Amino-5-(iso-propyl)thiazole
- Packaging
- 25mg
- Price
- $53
- Updated
- 2021/12/16
- Product number
- FA148152
- Product name
- 2-Amino-5-(iso-propyl)thiazole
- Packaging
- 50mg
- Price
- $92
- Updated
- 2021/12/16
- Product number
- P000208800
- Product name
- 5-Isopropylthiazol-2-amine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $113
- Updated
- 2021/12/16
- Product number
- FA148152
- Product name
- 2-Amino-5-(iso-propyl)thiazole
- Packaging
- 100mg
- Price
- $160
- Updated
- 2021/12/16
2-Thiazolamine, 5-(1-methylethyl)- Chemical Properties,Usage,Production
Synthesis
64932-36-1
17356-08-0
101080-15-3
General procedure: To a dichloromethane/dioxane (V/V = 4/1) solution of isovaleraldehyde (1.721 g, 20 mmol) was slowly added dropwise a dichloromethane/dioxane (V/V = 4/1) solution of bromine (1.0 mL, 20 mmol). The reaction mixture was stirred at 10 °C to give 2-bromoisovaleraldehyde intermediate. Subsequently, 2-bromoisovaleraldehyde intermediate was slowly added dropwise to a dichloromethane/dioxane (30 mL) solution of thiourea (1.523 g, 20 mmol). Ethanol (6 mL) and triethylamine (2.424 g, 24 mmol) were added and the reaction was carried out at room temperature for 20 hours. Upon completion of the reaction, 100 mL of distilled water was added to the reaction mixture and the pH was adjusted to 12 with 12 N sodium hydroxide solution. after continued stirring for 1 h at room temperature, extraction was carried out with dichloromethane and water. The organic layer was washed with saturated brine and dried with anhydrous magnesium sulfate. Finally, the target compound 5-isopropylthiazol-2-amine was purified by silica gel column chromatography to give the target compound 5-isopropylthiazol-2-amine (1.202 g, 42.26% yield).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 22, p. 5521 - 5525
[2] European Journal of Medicinal Chemistry, 1999, vol. 34, # 10, p. 883 - 889
[3] Patent: WO2005/95367, 2005, A1. Location in patent: Page/Page column 28
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 12, p. 4119 - 4132
[5] Journal of Medicinal Chemistry, 2011, vol. 54, # 12, p. 4119 - 4132
2-Thiazolamine, 5-(1-methylethyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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