METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE

Product Name: METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE
CAS No.: 98827-44-2
Chemical Name: METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE
Synonyms: Albb-008913;Tenoxicam Impurity 7;Tenoxicam Impurity 1;Lornoxicam Impurity 56;Methyl 4-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylate...;methyl 4-hydroxy-1,1-dioxo-2H-thieno[2,3-e]thiazine-3-carboxylate;Thyl 4-Hydroxy-2H-Thieno[2,3-E][1,2]Thiazine-3-Carboxylate 1,1-Dioxide;METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE;methy1 4-hydroxy-2H-thieno[2,3 -e]-1,2-thiazine-3-carboxylate-1, 1-dioxide;2H-Thieno[2,3-e]-1,2-thiazine-3-carboxylic acid, 4-hydroxy-, methyl ester, 1,1-dioxide
CBNumber: CB0186414
Molecular Formula: C8H7NO5S2
Formula Weight: 261.27
MOL File: 98827-44-2.mol

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METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE Property

Boiling point:: 464.2±55.0 °C(Predicted)
Density: 1.716
pka: 4.50±1.00(Predicted)

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 039962
Product name: Methyl 4-hydroxy-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide
Packaging: 500mg
Price: $126
Updated: 2021/12/16

AK Scientific

Product number: Y3312
Product name: Methy14-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide
Packaging: 500mg
Price: $220
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0090720
Product name: METHYL 4-HYDROXY-2H-THIENO[2,3-E][1,2]THIAZINE-3-CARBOXYLATE 1,1-DIOXIDE
Purity: 95.00%
Packaging: 0.5G
Price: $605
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0090720
Product name: METHYL 4-HYDROXY-2H-THIENO[2,3-E][1,2]THIAZINE-3-CARBOXYLATE 1,1-DIOXIDE
Purity: 95.00%
Packaging: 1G
Price: $646.8
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0090720
Product name: METHYL 4-HYDROXY-2H-THIENO[2,3-E][1,2]THIAZINE-3-CARBOXYLATE 1,1-DIOXIDE
Purity: 95.00%
Packaging: 5G
Price: $970.2
Updated: 2021/12/16

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METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE Chemical Properties,Usage,Production

Synthesis

106820-63-7

98827-44-2

General procedure for the synthesis of 4-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester-1,1-dioxide from methyl 3-sulfonamidoacetate-2-thiophenecarboxylate: 8.5 g of methyl 3-sulfonamidoacetate-2-thiophenecarboxylic acid methyl ester (TNXK-1), 27.2 g of a 7% sodium methanol solution, and 15 mL of anhydrous methanol were mixed. The reaction was heated to reflux with stirring and maintained for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with 200 mL of water. Subsequently, the reaction mixture was neutralized with 10% hydrochloric acid solution to pH 3. After neutralization, the solvent was removed by evaporation, the residue was cooled, and the pH was adjusted again with 10% hydrochloric acid to 3. The precipitate was collected by filtration, and the filter cake was washed with water and dried to give 5.6 g of the yellowish-green solid product, 4-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester-1,1 -dioxide (TNXK-2) The yield was 79%.

References

[1] Patent: CN107141308, 2017, A. Location in patent: Paragraph 0046-0050; 0064; 0068; 0074; 0078; 0084; 0088
[2] Journal of Medicinal Chemistry, 1987, vol. 30, # 4, p. 678 - 682

METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE Suppliers

China 63 Europe 1 India 3 United States 4 Global 71

Pharmaffiliates Analytics and Synthetics P. Ltd

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ProdList: 6739
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SynZeal Research Pvt Ltd

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CHEMSWORTH

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98827-44-2, METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDERelated Search:

TenoxicaM IMpurity E (2-Methylthieno[2,3-d]isothiazol-3(2H)-one-1,1-dioxide ) TenoxicaM IMpurity D (N-Methyl-N'-(2-pyridyl)oxaMide) AKOS 93309 Tenoxicam METHYL 2-METHYL-4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE 6-Chloro-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester 1,1-dioxide METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE AKOS 93419 AKOS 207-04 AKOS 93361 AKOS 93362 AKOS 93418 AKOS 93378 AKOS 207-05 AKOS 207-03 AKOS 93389 AKOS 90195

METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE

Tenoxicam Impurity 1

Albb-008913

methy1 4-hydroxy-2H-thieno[2,3 -e]-1,2-thiazine-3-carboxylate-1, 1-dioxide

methyl 4-hydroxy-1,1-dioxo-2H-thieno[2,3-e]thiazine-3-carboxylate

Methyl 4-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylate...

Tenoxicam Impurity 7

2H-Thieno[2,3-e]-1,2-thiazine-3-carboxylic acid, 4-hydroxy-, methyl ester, 1,1-dioxide

Lornoxicam Impurity 56

Thyl 4-Hydroxy-2H-Thieno[2,3-E][1,2]Thiazine-3-Carboxylate 1,1-Dioxide

98827-44-2