J&J Ex-61
- Product Name
- J&J Ex-61
- CAS No.
- 943540-75-8
- Chemical Name
- J&J Ex-61
- Synonyms
- CS-43;J&J Ex-61;JNJ-33877605;JNJ-38877605;JNJ 38877605 NEW;J&J Ex-61 USP/EP/BP;Venadaparib Impurity 19;JNJ38877605; JNJ-38877605;6-[difluoro-[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[3,4-f]...;6-[difluoro-[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline
- CBNumber
- CB01872310
- Molecular Formula
- C19H13F2N7
- Formula Weight
- 377.35
- MOL File
- 943540-75-8.mol
J&J Ex-61 Property
- Density
- 1.50
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥18.85 mg/mL in DMSO; ≥3.25 mg/mL in EtOH with ultrasonic
- form
- Powder
- pka
- 3.92±0.10(Predicted)
- color
- Off-white to light yellow
- CAS DataBase Reference
- 943540-75-8
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 27650
- Product name
- JNJ-38877605
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 27650
- Product name
- JNJ-38877605
- Packaging
- 100mg
- Price
- $838
- Updated
- 2024/03/01
- Product number
- 27650
- Product name
- JNJ-38877605
- Packaging
- 10mg
- Price
- $143
- Updated
- 2024/03/01
- Product number
- 27650
- Product name
- JNJ-38877605
- Packaging
- 50mg
- Price
- $463
- Updated
- 2024/03/01
- Product number
- J212505
- Product name
- JNJ-38877605
- Packaging
- 2.5mg
- Price
- $110
- Updated
- 2021/12/16
J&J Ex-61 Chemical Properties,Usage,Production
Uses
JNJ-38877605 is a potent inhibitor of c-Met catalytic activity. Selective over other tyrosine and serine-threonine kinases (600-fold selectivity). Ability to block constitutive or HGF-stimulated phosphorylation of c-Met demonstrated in vitro. JNJ 38877605 reduces radiation-induced invasion, apoptosis and proliferation of cancer cells in vitro.
Definition
ChEBI: 6-[difluoro-[6-(1-methyl-4-pyrazolyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline is a member of quinolines.
Biological Activity
jnj-38877605 is a small-molecule atp-competitive inhibitor of the catalytic activity of c-met.extensive evidence that c-met signaling is involved in the progression and spread of several cancers and an enhanced understanding of its role in disease have generated considerable interest in c-met and hgf asmajor targets in anti-cancer drug development.
in vitro
jnj-38877605 showed ~600-fold selectivity for c-met compared with a panel of ~250 diverse tyrosine and serine-threonine kinases and was found to potently inhibit hgf-stimulated and constitutively activated c-met phosphorylation in vitro [1].
in vivo
jnj-38877605 showed excellent oral bioavailability approaching 100% in all examined species. in addition, jnj-38877605 in a single dose was observed toinhibit met phosphorylation in tumor xenografts for up to16 h. inhibition of met phosphorylation was associated withdose-dependent tumor growth inhibition using a range of oral dosing regimens [2].
target
c-Met
References
[1] pererat, l avrijssent, janssens b, et al. jnj-38877605: a selective met kinase inhibitor inducingregression of met-driven tumor models. presented at the 99th aacr annual meeting; 2008 apr 12 -16;
J&J Ex-61 Preparation Products And Raw materials
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