N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

Product Name: N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
CAS No.: 136132-67-7
Chemical Name: N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
Synonyms: CPSB;CTSB;z-rr-amc;APP secretase;Z-RR-AMC, 2HCL;Z-ARG-ARG-MCA.HCL;Z-ARG-ARG-AMC 2HCL;Z-Arg-Arg-AMC/Z-RR-AMC;Cathepsin B Active human;Z-ARG-ARG-MCA HYDROCHLORIDE
CBNumber: CB0188887
Molecular Formula: C30H40ClN9O6
Formula Weight: 658.15
MOL File: 136132-67-7.mol

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N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Property

storage temp.: -20°C
form: aqueous solution
color: White to off-white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P201Obtain special instructions before use.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C5429
Product name: Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride
Packaging: 5mg
Price: $89.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: C5429
Product name: Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride
Packaging: 25mg
Price: $306
Updated: 2024/03/01

Sigma-Aldrich

Product number: 219392
Product name: Cathepsin B Substrate III, Fluorogenic
Purity: Sensitive fluorogenic substrate for the quantitative determination of cathepsin B activity.
Packaging: 25MG
Price: $171
Updated: 2024/03/01

Sigma-Aldrich

Product number: SRP0289
Product name: Cathepsin B Active human
Purity: recombinant, expressed in FreeStyle? 293-F cells, ≥90% (SDS-PAGE)
Packaging: 10μG
Price: $626
Updated: 2023/06/20

American Custom Chemicals Corporation

Product number: PEP0004304
Product name: Z-ARG-ARG-7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $634.11
Updated: 2021/12/16

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N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride has been used:

as a cathepsin B substrate in zymography analysis of protease in feces extract.
in cathepsin B activity assay.
as a fluorogenic peptide substrate to determine the matrix metalloproteinase enzyme activity.

General Description

Human cathepsin B (GenBank Accession No. NM_001908), CD33 signal peptide(amino acids 1-16) + Cathepsin B (amino acids 18-339), with C-terminal HIS tag, MW = 43 kDa, expressed in FreeStyle 293-F cells. Cathepsin B is a cysteine protease, found in the lysosome of normal cells and tissues. Cathepsin B active human is encoded by the gene CTSB, located on human chromosome 8p23.1.

Biochem/physiol Actions

Cathepsin B Active human primarily is a preproenzyme, glycosylated on rough endoplasmic reticulum. Processing of procathepsin B to a 31 kDa, single chain active form occurs in the lysosome. It is further processed to double chain form with a 25/26 kDa heavy chain and 5 kDa heavy chain in lysosome. Cathepsin B, functions as an exopeptidase at low pH. At higher pH in endosomes or neutral pH, cathepsin B functions as endopeptidase. Cathepsin B expression is upregulated in malignant tumors and facilitates tumor invasion. Cathepsin B might reduce the production of amyloid-β peptide associated with Alzheimerβs disease. It also plays a key role in neuroprotective functions.

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Suppliers

China 55 Switzerland 1 United Kingdom 3 United States 6 Global 65

SIGMA-RBI

Tel: --
Fax: --
Country: Switzerland
ProdList: 6896
Advantage: 91

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View Lastest Price from N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride 136132-67-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Career Henan Chemical Co

Product: N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE 136132-67-7
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2020-01-08

136132-67-7, N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDERelated Search:

Z-Arg-AMC CATHEPSIN B SUBSTRATE I, COLORIMETRIC N-ALPHA-CBZ-ARG-ARG-PRO-PHE-HIS-STA-ILE-HIS-N-EPSILON-BOC-LYS METHYL ESTER NA-CBZ-ARG-ARG 4-METHOXY-B-NAPHTHYLAMIDE Z-ARG-AMC HCL Perindopril L-Arginine N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Z-ARG-ARG-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN BENZYL N-(2-AMINOETHYL)CARBAMATE HYDROCHLORIDE L(+)-Arginine N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE H-ORN-AMC 2 HCL L-ARGININE 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE H-GLY-GLY-AMC HCL H-ARG-ALA-NH2 2 HCL L-ARGININE 7-AMIDO-4-METHYLCOUMARIN DIHYDROCHLORIDE 2-(METHYLAMINO)-N-(4-METHYLPHENYL)ACETAMIDE HYDROCHLORIDE H-ALA-ARG-AMC HCL

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

Z-ARG-ARG-7-AMIDO-4-METHYL COUMARIN, DIHCL

Z-ARG-ARG-AMC 2HCL

Z-ARG-ARG-AMC HYDROCHLORIDE SALT

Z-ARG-ARG-MCA HYDROCHLORIDE

Z-ARG-ARG-MCA(HYDROCHLORIDE FORM)

Z-L-ARGINYL-L-ARGININE-7-AMIDO-4-METHYLCOUMARIN 2HCL

Z-RR-AMC, 2HCL

z-arg-arg-7-amido-4-methylcoumarin hydrochloride

z-rr-amc

Z-ARG-ARG-MCA.HCL

ANTI-CATB (CENTER) antibody produced in rabbit

APP secretase

CPSB

CTSB

Cathepsin B Active human

Z-Arg-Arg-7-amido-4-methylcoumarin

BENZYLOXYCARBONYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE

CATHEPSIN B SUBSTRATE III, FLUOROGENIC

CATHEPSIN B SUBSTRATE IV, FLUOROGENIC

na-cbz-arg-arg 7-amido-4-methylcoumarin hydrochlo

NA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORI

N-CBZ-ILE-GLU-THR-ASP-7-AMINO-4- TRIFLUO ROMETHYLCOU

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride,Z-RR-AMC

Recombinant Human Cathepsin B/CTSB Protein, His Tag

Recombinant Mouse Cathepsin B/Ctsb Protein, His Tag

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE USP/EP/BP

Z-Arg-Arg-AMC/Z-RR-AMC

CBZ-Arg-Arg-7-amido-4-methylcoumarin hydrochloride

Mouse Anti-Caspase 8 antibody

Z-Arg-Arg-AMC hydrochloride

136132-67-7

C30H39N9O6

C30H41Cl2N9O6

C30H39N9O6HCl

Cathepsins and Granzymes

Cathepsin B

Caspases

Caspase 8

Cell Signaling and Neuroscience

Cell Biology

Apoptosis and Cell Cycle

BioChemical

Substrates