ChemicalBook > CAS DataBase List > (R)-(+)-HA-966

(R)-(+)-HA-966

Product Name
(R)-(+)-HA-966
CAS No.
123931-04-4
Chemical Name
(R)-(+)-HA-966
Synonyms
RMA-5;(+)-HA-966;HA966-001-R;Zinc03791818;(R)-(+)-HA-966;(R)(+)HA966,(R) (+) HA 966;R(+)-HA-966 R(+)-3-AMINO-1-HYDROX;(3R)-3-Amino-1-hydroxy-2-pyrrolidinone;R(+)-3-AMINO-1-HYDROXY-2-PYRROLIDINONE;(R)-(+)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE
CBNumber
CB0190556
Molecular Formula
C4H8N2O2
Formula Weight
116.12
MOL File
123931-04-4.mol
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(R)-(+)-HA-966 Property

Melting point:
166℃
Boiling point:
258.6±50.0 °C(Predicted)
Density 
1.436±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at RT
solubility 
H2O: soluble
form 
solid
pka
7.19±0.20(Predicted)
color 
white
optical activity
[α]22/D +103°, c = 1 in H2O(lit.)
Water Solubility 
Soluble to 100 mM in water
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H130
Product name
R(+)-HA-966
Purity
solid
Packaging
5mg
Price
$155.8
Updated
2025/07/31
Tocris
Product number
0281
Product name
(R)-(+)-HA-966
Purity
≥98%(HPLC)
Packaging
10
Price
$161
Updated
2021/12/16
TRC
Product number
H105803
Product name
(R)-(+)-HA-966
Packaging
50mg
Price
$730
Updated
2021/12/16
ApexBio Technology
Product number
B6243
Product name
(R)-(+)-HA-966
Packaging
10mg
Price
$234
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0007692
Product name
(R)-(+)-HA-966
Purity
95.00%
Packaging
10MG
Price
$673.08
Updated
2021/12/16
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(R)-(+)-HA-966 Chemical Properties,Usage,Production

Uses

(R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor.

Biological Activity

Antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .

in vivo

(R)-(+)-HA-966 ((+)-HA-966; 10 mg/kg; IV) significantly attenuates the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA (125, 250, 500, and 1000 mg/kg; i.v.)[3].
(+)-HA-966 (30, 100 mg/kg; IP) dose-dependently blocks the enhancement of dopamine synthesis induced in the nucleus accumbens by amphetamine, but is without effect on the increase in dopamine synthesis in the striatum in male BKTO mice (20-30g)[1].

Animal Model:Sprague-Dawley rats (11 to 12 weeks old)[3]
Dosage:10 mg/kg
Administration:IV
Result:Significantly attenuated the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA.

IC 50

NMDA Receptor

storage

Desiccate at RT

(R)-(+)-HA-966 Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-HA-966 Suppliers

China 34 Germany 2 Japan 1 Switzerland 1 United Kingdom 3 United States 9 USA 1 Global 51
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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Tetranov Biopharm
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13526569071
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sales@leadmedpharm.com
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China
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China DongFan Chemical Co.,LTD
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86-0571-85151182
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86-0571-85151182
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China
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EMMX Biotechnology LLC
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888-539-0666
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888-539-0666
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info@emmx.com
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Zhengzhou AiXi Technology Co., Ltd.
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0371-56787280 13137706083
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China
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XinYao(Shenzhen) Biological Technology Co., Ltd.
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0755-89880280
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3004662104@qq.com
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China
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Jinan Yaoyan Pharmaceutical Co., Ltd.
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jnyaoyan@163.com
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China
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Shandong Chengchuang Blue Sea Pharmaceutical Technology Co., Ltd.
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0531-58897130 15508676053
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drug_impurity@sdcclh.com
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China
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Nanjing Meihao Pharmaceutical Technology Co., Ltd.
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meitaochem@126.com
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meitaochem@126.com
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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123931-04-4, (R)-(+)-HA-966Related Search:

1H-Pyrrol-3-amine(9CI) AMINO ACID HYDROXAMATES GLYCINE HYDROXAMATE (S)-(-)-HA-966 (+/-)-HA-966 3-AMINO-PYRROLIDIN-2-ONE (+/-)-HA-966 (R)-3-Aminopyrrolidine (R)-(+)-HA-966

  • R(+)-HA-966 R(+)-3-AMINO-1-HYDROX
  • (R)-(+)-HA-966
  • R(+)-3-AMINO-1-HYDROXY-2-PYRROLIDINONE
  • (R)-(+)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE
  • Zinc03791818
  • (3R)-3-Amino-1-hydroxy-2-pyrrolidinone
  • (R)-3-amino-1-hydroxypyrrolidin-2-one 2,2,2-trifluoroacetate
  • 2-Pyrrolidinone, 3-amino-1-hydroxy-, (3R)-
  • (+)-HA-966
  • HA966-001-R
  • (R)(+)HA966,(R) (+) HA 966
  • RMA-5
  • 123931-04-4
  • Ion Channels
  • Ionotropic Glutamate Receptor Modulators
  • Ligand-Gated Ion Channels
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Glutamate receptor