5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER

Product Name: 5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
CAS No.: 106726-82-3
Chemical Name: 5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
Synonyms: 5-Cyanonicotinic acid methyl ester;Methyl 5-cyano-3-pyridinecarboxylate;Methyl 5-cyano-pyridin-3-carboxylate;METHYL-5-CYANOPYRIDINE-3-CARBOXYLATE;5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER;3-Pyridinecarboxylic acid, 5-cyano-, methyl ester;5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER ISO 9001：2015 REACH
CBNumber: CB0192116
Molecular Formula: C8H6N2O2
Formula Weight: 162.15
MOL File: 106726-82-3.mol

More

Less

5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER Property

Boiling point:: 269.2±25.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: -0.25±0.20(Predicted)
Appearance: White to off-white Solid

More

Less

Safety

HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TRC

Product number: M340058
Product name: Methyl5-Cyanopyridine-3-carboxylate
Packaging: 50mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC150125
Product name: 5-Cyano-3-pyridinecarboxylic acid methylester
Packaging: 100mg
Price: $112
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC150125
Product name: 5-Cyano-3-pyridinecarboxylic acid methylester
Packaging: 500mg
Price: $390
Updated: 2021/12/16

AK Scientific

Product number: X8812
Product name: Methyl5-cyanonicotinate
Packaging: 1g
Price: $207
Updated: 2021/12/16

Apolloscientific

Product number: OR931210
Product name: 5-Cyano-3-pyridinecarboxylicacidmethylester
Purity: 95%
Packaging: 250mg
Price: $225
Updated: 2021/12/16

More

Less

5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production

Synthesis

29681-44-5

544-92-3

106726-82-3

The general procedure for the synthesis of methyl 5-cyano-3-pyridinecarboxylate from methyl 5-bromonicotinate and cuprous cyanide was as follows: methyl 5-bromonicotinate (2.16 g, 10.0 mmol, 1.0 eq.) and cuprous(I) cyanide (1.79 g, 20.0 mmol, 2.0 eq.) were dissolved in anhydrous DMF (10 mL), and the reaction was carried out at reflux for 15 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction mixture was filtered through a diatomaceous earth pad and rinsed with ethyl acetate (100 mL). Formation of a black precipitate was observed in the filtrate. Subsequently, the filtrate was washed with saturated saline (3 x 100 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated by rotary evaporation at 40 °C to give 546 mg (33.7% yield) of light yellow solid product. The crude product was further purified by silica gel column chromatography (column size: 80 mm in diameter × 20 mm in height) with an eluent of 20-35% ethyl acetate/hexane mixture, resulting in 501 mg (30.9% yield) of methyl 5-cyano-3-pyridinecarboxylate as an off-white solid. Mass spectrometry result: m/e 163.07 ([M+H]+).

References

[1] Patent: WO2005/66126, 2005, A1. Location in patent: Page/Page column 66

5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER Suppliers

China 63 Germany 1 India 2 United Kingdom 2 United States 11 Global 79

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

ZEROSCHEM.CO.,LTD.

Tel: 10-61256048 13810278579
Fax: +86 10 61256049
Email: sales@zeroschem.com
Country: China
ProdList: 1370
Advantage: 59

Wuhan ariel chemical Co., LTD.

Tel: 18986259541
Fax: 027-87840182
Email: sales@3stc.com
Country: China
ProdList: 3764
Advantage: 58

Shanghai Synthfine Chemical Co.,Ltd

Tel: 15921303235
Fax: QQ489466966
Email: sales@synthfine.com
Country: China
ProdList: 1043
Advantage: 58

ShldaTech. Co., Ltd.

Tel: 18014808303 18014808303
Fax: +86-25-58353700
Email: sales@rennotech.com
Country: China
ProdList: 60
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Modachem Shanghai Co., Ltd

Tel: +86 (0)21 51320687 51371369 1744605818
Fax: +86 (0)21 51371369
Country: China
ProdList: 1578
Advantage: 58

Jinan LuoHe PharmaTech Co., Ltd.

Tel: 86-0531-68658065 15726150375
Fax: 0531-68658065
Email: 1071018499@qq.com
Country: China
ProdList: 526
Advantage: 58

LABTER PHARMATECH(BEIJING) CO.,LTD

Tel: 010-56330744 18310155299
Fax: 010-56330744
Email: sales@labter.com.cn
Country: China
ProdList: 20000
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

More

Less

View Lastest Price from 5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER 106726-82-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER 106726-82-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER 106726-82-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

106726-82-3, 5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTERRelated Search:

ETHYL 2-CHLORO-3-CYANO-6-(TRIFLUOROMETHYL)-PYRIDINE-5-CARBOXYLATE METHYL 5-CYANO-6-HYDROXY-2-METHYLNICOTINATE ETHYL 5-CYANO-6-MERCAPTO-2-METHYLNICOTINATE 2-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER 5-CYANO-3-PYRIDINECARBOXYLIC ACID ETHYL 5-CYANO-6-MERCAPTO-2-PHENYLNICOTINATE METHYL 5-CYANO-2-METHYL-6-[3-(TRIFLUOROMETHYL)PHENOXY]NICOTINATE METHYL 5-CYANO-2-(DIMETHOXYMETHYL)-6-MERCAPTONICOTINATE BUTTPARK 82\12-87 AURORA KA-6192 METHYL 5-CYANO-6-(2-METHOXYPHENOXY)-2-METHYLNICOTINATE METHYL 5-CYANO-2-METHYL-6-PHENOXYNICOTINATE METHYL 5-CYANO-6-(4-METHOXYPHENOXY)-2-METHYLNICOTINATE ETHYL 5-CYANO-6-([2-(([(2,6-DICHLORO-4-PYRIDYL)AMINO]CARBONYL)AMINO)PHENYL]THIO)-2-(TRIFLUOROMETHYL)NICOTINATE METHYL 5-CYANO-6-METHOXY-2-METHYLNICOTINATE 2,4-DIMETHYL-5-OXO-5H-CHROMENO[3,4-C]PYRIDINE-1-CARBONITRILE ETHYL 5-CYANO-6-(METHYLSULFANYL)-2-PHENYLNICOTINATE METHYL 5-CYANO-2-METHYL-6-(PHENYLSULFANYL)NICOTINATE

5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER

METHYL-5-CYANOPYRIDINE-3-CARBOXYLATE

Methyl 5-cyano-pyridin-3-carboxylate

5-Cyanonicotinic acid methyl ester

3-Pyridinecarboxylic acid, 5-cyano-, methyl ester

5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER ISO 9001：2015 REACH

Methyl 5-cyano-3-pyridinecarboxylate

106726-82-3

Pyridine series