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H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2

Product Name
H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2
CAS No.
109212-72-8
Chemical Name
H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2
Synonyms
(D-Pro2,D-Trp6;DPHDFWVWL-NLE-NH2;(D-Pro?,D-Trp?·?,Nle??)-Neurokinin B;(D-PRO2,D-TRP6,8,NLE10)-NEUROKININ B;ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2;H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2;L-Norleucinamide,L-α-aspartyl-D-prolyl-L-histidyl-L-α-aspartyl-L-phenylalanyl-D-tryptophyl-L-valyl-D-tryptophyl-L-leucyl-;L-Norleucinamide, L-α-aspartyl-D-prolyl-L-histidyl-L-α-aspartyl-L-phenylalanyl-D-tryptophyl-L-valyl-D-tryptophyl-L-leucyl- (9CI)
CBNumber
CB0194367
Molecular Formula
C67H87N15O14
Formula Weight
1326.5
MOL File
109212-72-8.mol
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H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2 Property

Boiling point:
1725.7±65.0 °C(Predicted)
Density 
1.338±0.06 g/cm3(Predicted)
storage temp. 
-15°C
pka
3.82±0.19(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
PEP0000120
Product name
[D-PRO2, D-TRP6,8, NLE10]-NEUROKININ B
Purity
95.00%
Packaging
1MG
Price
$679.14
Updated
2021/12/16
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H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2 Chemical Properties,Usage,Production

Uses

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A[1].

in vivo

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B (1 mg/kg i.v.) significantly reduces Substance P- and Neurokinin B- but not acetylcholine- or Neurokinin A-induced salivation. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B lowers blood pressure in anesthetized rats by 35 to 40%[2].

References

[1] H I Jacoby, et al. Differentiation of multiple neurokinin receptors in the guinea pig ileum. Life Sci. 1986 Nov 24;39(21):1995-2003. DOI:10.1016/0024-3205(86)90323-1
[2] C W Murray, et al. Neurokinin-induced salivation in the anesthetized rat: a three receptor hypothesis. J Pharmacol Exp Ther. 1987 Aug;242(2):500-6. DOI:10.1016/0024-3205(86)90323-1

H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2 Suppliers

China 54 The Netherlands 1 United States 4 Global 59
Brunschwig chemie
Tel
--
Fax
--
Email
brunschwig@brunschwig.nl
Country
The Netherlands
ProdList
4996
Advantage
67
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View Lastest Price from H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2 manufacturers

Career Henan Chemical Co
Product
H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2 109212-72-8
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2020-03-05

109212-72-8, H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2Related Search:

Neurokinin B

  • ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2
  • (D-PRO2,D-TRP6,8,NLE10)-NEUROKININ B
  • DPHDFWVWL-NLE-NH2
  • H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2
  • (D-Pro2,D-Trp6
  • L-Norleucinamide, L-α-aspartyl-D-prolyl-L-histidyl-L-α-aspartyl-L-phenylalanyl-D-tryptophyl-L-valyl-D-tryptophyl-L-leucyl- (9CI)
  • L-Norleucinamide,L-α-aspartyl-D-prolyl-L-histidyl-L-α-aspartyl-L-phenylalanyl-D-tryptophyl-L-valyl-D-tryptophyl-L-leucyl-
  • (D-Pro?,D-Trp?·?,Nle??)-Neurokinin B
  • 109212-72-8
  • C67H87N15O14
  • peptide