TRIFLUOROMETHIONINE
- Product Name
- TRIFLUOROMETHIONINE
- CAS No.
- 764-52-3
- Chemical Name
- TRIFLUOROMETHIONINE
- Synonyms
- TRIFLUOROMETHIONINE;trifluoro-L-methionine;S-(Trifluoromethyl)-L-homocysteine;L-Homocysteine,S-(trifluoromethyl)-;(S)-2-Amino-4-((trifluoromethyl)thio)butanoic acid;(2S)-2-amino-4-[(trifluoromethyl)sulfanyl]butanoic acid
- CBNumber
- CB0194392
- Molecular Formula
- C5H8F3NO2S
- Formula Weight
- 203.18
- MOL File
- 764-52-3.mol
TRIFLUOROMETHIONINE Property
- Melting point:
- 227-228 °C(Solv: water (7732-18-5); methanol (67-56-1))
- Boiling point:
- 260.6±40.0 °C(Predicted)
- Density
- 1.450±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.19±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C5H8F3NO2S/c6-5(7,8)12-2-1-3(9)4(10)11/h3H,1-2,9H2,(H,10,11)/t3-/m0/s1
- InChIKey
- YLJLTSVBCXYTQK-VKHMYHEASA-N
- SMILES
- C(O)(=O)[C@H](CCSC(F)(F)F)N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- AAA0004929
- Product name
- TRIFLUOROMETHIONINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.13
- Updated
- 2021/12/16
TRIFLUOROMETHIONINE Chemical Properties,Usage,Production
Definition
ChEBI: An L-alpha-amino acid, methionine, with the S-methyl group trifluoro-substituted.
Synthesis
626-72-2
2314-97-8
764-52-3
The general procedure for the synthesis of (S)-2-amino-4-((trifluoromethyl)thio)butyric acid from L-homocysteine and trifluoroiodomethane was as follows: first, 10.0 g (37.3 mmol) of L-homocysteine was added to a 500 mL three-necked flask equipped with a liquid ammonia cooling unit, glass stirring bar, thermometer, and diaphragm rubber cap. The flask was then flushed thoroughly with nitrogen to remove air. After cooling the flask to -78°C, ammonia dried through a KOH tube was liquefied in a liquid ammonia cooling unit cooled in a dry ice-acetone bath, about 100 mL of liquid ammonia was added to the L-homocysteine, and stirring was started. Next, 3.58 g (156 mmol) of sodium metal was slowly added while controlling the reaction temperature to not exceed -35°C. During this process, the color of the solution (mixture) changed to a dark blue. Then, 18.2 g (93.3 mmol) of trifluoromethyl iodine weighed with a balloon was added and stirred in a bath at -78°C for 20 min. Afterwards, the ammonia was gradually evaporated, the residue was dissolved in ultrapure water, and the solution was purified by passing it through an ion exchange resin DOWEX-50X8 pre-treated with hydrochloric acid. After rinsing with a sufficient amount of ultrapure water, the solution was eluted using 2% ammonia solution, and 14.1 g of the target product, L-trifluoromethionine, was finally obtained in 93% yield. The structure of the product was confirmed by 1H-NMR (D2O, 200 MHz) δ: 2.07-2.37 (m, 2H), 3.01 (t, 2H, J = 7.6 Hz), 4.03 (t, 1H, J = 6.6 Hz) and 19F-NMR (D2O, 188 MHz) δ: -41.3 (s).
References
[1] Patent: US2011/15433, 2011, A1. Location in patent: Page/Page column 4
[2] Journal of Fluorine Chemistry, 2011, vol. 132, # 3, p. 186 - 189
TRIFLUOROMETHIONINE Preparation Products And Raw materials
Raw materials
Preparation Products
TRIFLUOROMETHIONINE Suppliers
- Tel
- 15061806929
- linda-fu@mimotopes.cn
- Country
- China
- ProdList
- 5796
- Advantage
- 58
- Tel
- +49 5662 408730
- Fax
- +49 5662 4087320
- info@synchem.de
- Country
- Germany
- ProdList
- 4705
- Advantage
- 70
- Tel
- +86-21-61263340; 17609490614 13764994101
- Fax
- 021-61263399
- fisherwang@glschina.com
- Country
- China
- ProdList
- 8258
- Advantage
- 55
- Tel
- 0510-86010668
- Fax
- 0510-86010668
- sales@biopharmamatrix.com
- Country
- China
- ProdList
- 4739
- Advantage
- 55
- Tel
- 0510-83583050 13771062561
- Fax
- 0510-83583039
- willsun@peptide-search.com
- Country
- China
- ProdList
- 6716
- Advantage
- 58
- Tel
- 025-58361106-805 15951641583
- Fax
- 025-58361106-806
- zhao.xu@njpeptide.com
- Country
- China
- ProdList
- 9979
- Advantage
- 55
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- 021-61263370 18901917034
- xingli@glbiochem.com
- Country
- China
- ProdList
- 5637
- Advantage
- 58
- Tel
- 021-61263377 15023907684
- Fax
- 021-61263399
- 15800684150@163.com
- Country
- China
- ProdList
- 8131
- Advantage
- 58
- Tel
- +86-0571-81612335 +8613336028439
- sales@nextpeptide.com
- Country
- China
- ProdList
- 19908
- Advantage
- 58