2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene]

Product Name: 2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene]
CAS No.: 445222-91-3
Chemical Name: 2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene]
Synonyms: EMBL;MuRF1-IN-1;MuRF1-IN-1, 10 mM in DMSO;MuRF1IN1,inhibit,Inhibitor,MuRF1 IN 1,MuRF-1-IN-1;2-Amino-1'-methyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile;2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene];Spiro[4H-1-benzopyran-4,3'-[3H]indole]-3-carbonitrile, 2-amino-1',2',5,6,7,8-hexahydro-1'-methyl-2',5-dioxo-
CBNumber: CB01966147
Molecular Formula: C18H15N3O3
Formula Weight: 321.33
MOL File: 445222-91-3.mol

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2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Property

Melting point:: 247-248 °C(Solv: ethanol (64-17-5))
Boiling point:: 716.6±60.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (389.01 mM; Need ultrasonic)
pka: 2.42±0.20(Predicted)
form: Solid
color: Off-white to gray

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Hazard and Precautionary Statements (GHS)

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2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Chemical Properties,Usage,Production

Biological Activity

MuRF1-IN-1 is a muscle ring finger 1 (MuRF1) inhibitor that attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia[1].

References

[1]. Bowen TS, Adams V, Werner S, et al. Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):939-953.

2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] Suppliers

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445222-91-3, 2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene]Related Search:

2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene]

MuRF1-IN-1

EMBL

2-Amino-1'-methyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile

MuRF1IN1,inhibit,Inhibitor,MuRF1 IN 1,MuRF-1-IN-1

Spiro[4H-1-benzopyran-4,3'-[3H]indole]-3-carbonitrile, 2-amino-1',2',5,6,7,8-hexahydro-1'-methyl-2',5-dioxo-

MuRF1-IN-1, 10 mM in DMSO

445222-91-3