1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE
- Product Name
- 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE
- CAS No.
- 287471-30-1
- Chemical Name
- 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE
- Synonyms
- 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE;Terbinafine Impurity 45;Terbinafine Impurity 22;1-Chloro-6,6-dimethyl-2-hepten-4-yne;2-HEPTEN-4-YNE,1-CHLORO-6,6-DIMETHYL;1-Chloro-6,6-dimethyl-2-hepten-4-ino;(E)-1-chloro-6,6-diMethylhept-2-en-4-yne;(2E)-1-chloro-6,6-dimethylhept-2-en-4-yne;1-CHLORO-6,6-DIMETHYL-2-ENE-4-YNE-HEPTANE;2-HEPTEN-4-YNE, 1-CHLORO-6,6-DIMETHYL-, (2E)-
- CBNumber
- CB0198486
- Molecular Formula
- C9H13Cl
- Formula Weight
- 156.65
- MOL File
- 287471-30-1.mol
1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Property
- Boiling point:
- 207.5±23.0 °C(Predicted)
- Density
- 0.946±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere, 2-8°C
- InChI
- InChI=1S/C9H13Cl/c1-9(2,3)7-5-4-6-8-10/h4,6H,8H2,1-3H3/b6-4+
- InChIKey
- ZIXABMZBMHDFEZ-GQCTYLIASA-N
- SMILES
- C(Cl)/C=C/C#CC(C)(C)C
- CAS DataBase Reference
- 287471-30-1(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- HCH0036879
- Product name
- (2E)-1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $1404.36
- Updated
- 2021/12/16
1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Chemical Properties,Usage,Production
Description
1-Chloro-6,6-dimethyl-2-hepten-4-yne is the allylamine antifungal agents terbinafine intermediate.1-Chloro-6,6-dimethyl-2-hepten-4-yne choose to inhibit COX-fungal squalene, so that reduction of membrane ergosterol, thus inhibiting the growth of fungi play an inhibitory role; right ergosterol synthesis of precursors and no inhibitory effect on other stages.
Uses
1-Chloro-6,6-dimethyl-2-heptene-4-yne is a hydrocarbon derivative and can be used as a pharmaceutical intermediate.
Application
1-Chloro-6,6-dimethyl-2-hepten-4-yne is a chlorinating agent that has been used to minimise hydrochloric acid by converting it to chloride. It is also used in the chlorination of magnesium and other metals. 1-Chloro-6,6-dimethyl-2-hepten-4-yne has been shown to be an effective antifungal agent against dermatophytes such as Trichophyton rubrum and Microsporum canis. The compound is toxic to humans and animals because it produces acrolein and terbinafine during chlorination. It also produces hydrochloric acid as a by-product of chlorination.
Synthesis
1-Chloro-6,6-dimethyl-2-hepten-4-yne mainly due to keratin aggregation produce squalene, was squalene cyclooxygenase inhibition, squalene in the cells of a large number gathered in the form of lipid droplets penetrate fungal cell membrane, destruction of the membrane lipid composition, resulting in fungal death. A typical procedure for preparing of 1-chloro-6,6-dimethyl-2-hepten-4-yne using boron trichloride is as follows: Compound 1 (53 g, 0.38 mol) in 2800 mL of n-hexane was cooled to 10??15??. Boron trichloride (1 M in hexane, 480 mL, 0.48 mol) was added to the mixture at 15??20?? over a 10 min period. After 10 min of stirring at 20??, the mixture was quenched with 1000 mL of water and stirred for 10 min. The separated organic phase was washed with 20% NaCl, dried (MgSO4), and evaporated to afford the title compound 2 (57.1 g, 95%) in 9:1 E:Z ratio.
1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Preparation Products And Raw materials
Raw materials
Preparation Products
1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Suppliers
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- Product
- 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE 287471-30-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99% HPLC
- Supply Ability
- 100 kgs
- Release date
- 2023-07-19
- Product
- 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE 287471-30-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE 287471-30-1
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-17