ChemicalBook > CAS DataBase List > LY 341495

LY 341495

Product Name: LY 341495
CAS No.: 201943-63-7
Chemical Name: LY 341495
Synonyms: CS-416;LY 341495;LY 341495;LY-341495;LY341495, 10 mM in DMSO;LY 341495, Group II antagonist;9H-Xanthene-9-propanoic acid, α-amino-α-[(1S,2S)-2-carboxycyclopropyl]-, (αS)-;(2S)-2-AMINO-2-[(1S,2S)-2-CARBOXYCYCLOPROP-1-YL]-3-(XANTH-9-YL) PROPANOIC ACID;(alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid;(1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acid;(alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid LY 341495
CBNumber: CB0200679
Molecular Formula: C20H19NO5
Formula Weight: 353.37
MOL File: 201943-63-7.mol

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LY 341495 Property

Boiling point:: 580.8±40.0 °C(Predicted)
Density: 1.432
storage temp.: Store at RT
solubility: Limited solubility, soluble in DMSO
form: crystalline solid
pka: 2.02±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14693
Product name: LY341495
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 14693
Product name: LY341495
Purity: ≥98%
Packaging: 10mg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 14693
Product name: LY341495
Purity: ≥98%
Packaging: 50mg
Price: $745
Updated: 2024/03/01

Tocris

Product number: 1209
Product name: LY341495
Purity: ≥98%(HPLC)
Packaging: 50
Price: $1092
Updated: 2021/12/16

Tocris

Product number: 1209
Product name: LY341495
Purity: ≥98%(HPLC)
Packaging: 1
Price: $108
Updated: 2021/12/16

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LY 341495 Chemical Properties,Usage,Production

Uses

LY-341495 is a potent and selective group II metabotropic glutamate receptor (mGluR) antagonist.

Uses

LY 341495 is a potent and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC50s = 21 and 14 nM, respectively, for human isoforms). It less effectively blocks mGluR8 and mGluR7 (IC50s = 173 and 990 nM, respectively) and weakly antagonizes mGluR1, mGluR5, and mGluR4 (IC50s = 6.8, 8.2, and 22 μM, respectively). In rat forebrain tissue, LY341495 may bind mGluR3 more avidly than mGluR2. LY341495 can be effectively used in isolated cells, tissues, and in vivo. In mice, it penetrates the blood-brain barrier and has been used to study the roles of mGlu2/3 receptors in the brain.[Cayman Chemical]

Definition

ChEBI: (1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-1-cyclopropanecarboxylic acid is a member of xanthenes.

Biological Activity

Highly potent and selective group II metabotropic glutamate receptor antagonist (K i /IC 50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu 2 , mGlu 3 , mGlu 8 , mGlu 7a , mGlu 1a , mGlu 5a and mGlu 4a receptors respectively). Readily brain penetrant and active in vivo . Also available as part of the Group II mGlu Receptor Tocriset™ , Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .

in vivo

LY341495 (0.3, 1, and 3 mg/kg, i.p.) displays a lower level of discrimination in rats^[1]. LY341495 (3.0 mg/kg) decreases Dvl-2, pGSK-3α/β and β-catenin protein levels but Dvl-1, Dvl-3 and GSK-3α/β are unaffected in both the PFC and STR. LY341495 has the generally the opposite effect following acute and chronic administration compared to mGlu2/3 agonist, LY379268^[2]. LY341495 (3 mg/kg, i.p., 2.5 h) -induced c-Fos expression is not altered in either KO brain. LY341495 is almost inactive in the central extended amygdala [central nucleus of the amygdala, lateral (CeL) and bed nucleus of the stria terminalis, laterodorsal (BSTLD)] in mGluR3-KO mice^[3].

IC 50

mGluR1a: 7.8 μM (IC₅₀); mGluR2: 21 nM (IC₅₀); mGluR3: 14 nM (IC₅₀); mGluR4: 22 μM (IC₅₀); mGluR5a: 8.2 μM (IC₅₀); mGluR7: 990 nM (IC₅₀); mGluR8: 170 nM (IC₅₀)

storage

Room temperature

References

[1] kingston a e, ornstein p l, wright r a, et al. ly341495 is a nanomolar potent and selective antagonist of group ii metabotropic glutamate receptors. neuropharmacology, 1998, 37(1): 1-12.
[2] fitzjohn s m, bortolotto z a, palmer m j, et al. the potent mglu receptor antagonist ly341495 identifies roles for both cloned and novel mglu receptors in hippocampal synaptic plasticity. neuropharmacology, 1998, 37(12): 1445-1458.
[3] pitsikas n, kaffe e, markou a. the metabotropic glutamate 2/3 receptor antagonist ly341495 differentially affects recognition memory in rats. behavioural brain research, 2012, 230(2): 374-379.

LY 341495 Preparation Products And Raw materials

Raw materials

Preparation Products

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201943-63-7, LY 341495Related Search:

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LY 341495

(2S)-2-AMINO-2-[(1S,2S)-2-CARBOXYCYCLOPROP-1-YL]-3-(XANTH-9-YL) PROPANOIC ACID

(alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid LY 341495

(alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid

CS-416

(1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acid

LY 341495;LY-341495

9H-Xanthene-9-propanoic acid, α-amino-α-[(1S,2S)-2-carboxycyclopropyl]-, (αS)-

LY 341495, Group II antagonist

LY341495, 10 mM in DMSO

201943-63-7

Glutamate