4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Product Name
- 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 138022-02-3
- Chemical Name
- 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- 1-Boc-4-[(Methylamino)methyl]piperidine;1-N-BOC-4-[(METHYLAMINO)METHYL]PIPERIDINE;tert-butyl 4-((MethylaMino)Methyl)piperidin-1-carboxylate;1-piperidinecarboxylic acid, 4-[(methylamino)methyl]-, 1,1;TERT-BUTYL 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLATE;tert-Butyl 4-[(methylamino)methyl]-1-piperidinecarboxylate;tert-butyl 2-methyl-4-(methylamino)piperidine-1-carboxylate;1,1-Dimethylethyl 4-[(methylamino)methyl]-1-piperidinecarboxylate;4-(methylaminomethyl)-1-piperidinecarboxylic acid tert-butyl ester;4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CBNumber
- CB0204152
- Molecular Formula
- C12H24N2O2
- Formula Weight
- 228.33
- MOL File
- 138022-02-3.mol
4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property
- Boiling point:
- 301.0±15.0 °C(Predicted)
- Density
- 0.988
- storage temp.
- 2-8°C(protect from light)
- pka
- 10.41±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M331013
- Product name
- 4-[(Methylamino)methyl]piperidine-1-carboxylicAcidtert-ButylEster
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 072365
- Product name
- 4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester
- Purity
- 95+%
- Packaging
- 5g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 072365
- Product name
- 4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester
- Purity
- 95+%
- Packaging
- 10g
- Price
- $308
- Updated
- 2021/12/16
- Product number
- W3005
- Product name
- 4-[(Methylamino)methyl]piperidine-1-carboxylicacidtert-butylester
- Packaging
- 10g
- Price
- $248
- Updated
- 2021/12/16
- Product number
- CHM0068653
- Product name
- 4-METHYLAMINOMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $770
- Updated
- 2021/12/16
4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Synthesis
544696-01-7
138022-02-3
General procedure for the synthesis of tert-butyl 4-[(methylamino)methyl]piperidine-1-carboxylate from 1-Boc-4-piperidinyl-N-methylamide: 5.76 g (16.64 mmol) of tert-butyl 4-methylcarbamoyl-piperidine-1-carboxylate was dissolved in 60 mL of anhydrous THF. The solution was slowly added to a 60 mL THF suspension containing 1.4 g (37 mmol) of sodium borohydride at 0 °C and stirred for 30 min. Subsequently, 4.2 g (16.54 mmol) of iodine was added to the 60 mL THF solution. The reaction mixture was heated to reflux and maintained for 18 hours. After completion of the reaction, the mixture was cooled to room temperature and 150 mL of methanol was added slowly and dropwise. The reaction mixture was concentrated and sodium hydroxide solution was added. The reaction mixture was extracted with tert-butyl methyl ether. The organic phases were combined and dried over anhydrous sodium sulfate. A final product of 5 g was obtained in 60% yield of the theoretical value and EI mass spectrum showed m/z = 229 [M + H]+.
References
[1] Patent: WO2008/71646, 2008, A1. Location in patent: Page/Page column 80
[2] Patent: WO2005/7658, 2005, A2. Location in patent: Page 230
4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers
- Product
- 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 138022-02-3
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-03