AM 404
- Product Name
- AM 404
- CAS No.
- 198022-70-7
- Chemical Name
- AM 404
- Synonyms
- AM 404;Zinc03871503;N-arachidonoylaminophenol;AM 404 (in Tocrisolve 100);AM 404 (in Tocrisolve(TM) 100);N-(4-HYDROXYPHENYL)-ARACHIDONAMIDE;N-(4-HYDROXYPHENYL)ARACHIDONYLAMIDE;N-(4-HYDROXYPHENYL) ARACHIDONOYLAMIDE;ARACHIDONOYLAMIDE, N-(4-HYDROXYPHENYL);N-(4-HYDROXYPHENYL)ARACHIDONYLAMIDE \ AN
- CBNumber
- CB0205078
- Molecular Formula
- C26H37NO2
- Formula Weight
- 395.58
- MOL File
- 198022-70-7.mol
AM 404 Property
- storage temp.
- −20°C
- solubility
- ethanol: 24 mg/mL Photosensitive solution.
- form
- solution
- color
- White
- Sensitive
- Air Sensitive
- Stability:
- Stable for 1 year from date of purchase as supplied. Compound is subject to oxidation, store under inert gas to protect from exposure to air. Solutions in DMSO or ethanol may be stored under nitrogen or argon at -20° for up to 3 months.
Safety
- Hazard Codes
- F,Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 7-16-36-26
- RIDADR
- UN 1170 3/PG 2
- WGK Germany
- 1
N-Bromosuccinimide Price
- Product number
- J67201
- Product name
- AM-404, 98%
- Packaging
- 10mg
- Price
- $95.8
- Updated
- 2021/12/16
- Product number
- 0045CQ
- Product name
- N-(4-Hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide
- Packaging
- 5mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 0045CQ
- Product name
- N-(4-Hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide
- Packaging
- 10mg
- Price
- $148
- Updated
- 2021/12/16
- Product number
- B6604
- Product name
- AM404
- Packaging
- 10mg
- Price
- $153
- Updated
- 2021/12/16
- Product number
- B6604
- Product name
- AM404
- Packaging
- 50mg
- Price
- $646
- Updated
- 2021/12/16
AM 404 Chemical Properties,Usage,Production
Description
AM-404 (198022-70-7) inhibits anandamide transport (IC50?= 1 μM) without inhibiting anandamide amidase or activating cannabinoid receptors.1,2?Vanilloid receptors are activated by AM-404.3?Active?in vivo.1
Biological Activity
Competitive and selective inhibitor of carrier-mediated anandamide transport (IC 50 = 1 μ M). Does not activate CB 1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC 50 = 7.4). Active in vivo . Also available in water soluble emulsion (N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide ).
References
1) Calignano?et al. (1997),?Potentiation of anandamide hypotension by the transport inhibitor AM404; Eur. J. Pharmacol.,?337?R1 2) Beltramo?et al. (1997), Functional role of high-affinity anandamide transport, as revealed by selective inhibition; Science,?277?1094 3) Zygmunt?et al. (2000),?The anandamide inhibitor AM404 activates vanilloid receptors: Eur. J. Pharmacol.?396?39
AM 404 Preparation Products And Raw materials
Raw materials
Preparation Products
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