(2R,5S)-5-AMINO-8-GUANIDINO-4-OXO-2-P-HYDROXYPHENYLMETHYLOCTANOIC ACID HEMISULFATE MONOHYDRATE

Product Name: (2R,5S)-5-AMINO-8-GUANIDINO-4-OXO-2-P-HYDROXYPHENYLMETHYLOCTANOIC ACID HEMISULFATE MONOHYDRATE
CAS No.: 144110-38-3
Chemical Name: (2R,5S)-5-AMINO-8-GUANIDINO-4-OXO-2-P-HYDROXYPHENYLMETHYLOCTANOIC ACID HEMISULFATE MONOHYDRATE
Synonyms: ARPHAMENINE B;arphamenine B hemisulfate;ARPHAMENINE B HEMISULFATE MONOHYDRATE;Arphamenine B hemisulfate salt hydrate;Arphamenine B hydrate hemisulfate salt;ARPHAMENINE B HEMISULFATE HYDRATE*FROM MICROBIAL SOU;(2R,5S)-5-Amino-8-guanido-4-oxo-2-p-hydroxyphenylmethyloctanoic acid;5-amino-8-(diaminomethylideneamino)-2-[(4-hydroxyphenyl)methyl]-4-oxooctanoic acid;(2R,5S)-5-AMINO-8-GUANIDINO-4-OXO-2-P-HYDROXYPHENYLMETHYLOCTANOIC ACID, HEMISULFATE;(2R,5S)-5-AMINO-8-GUANIDINO-4-OXO-2-P-HYDROXYPHENYLMETHYLOCTANOIC ACID (SULFATE FORM)
CBNumber: CB0210137
Molecular Formula: C32H52N8O13S
Formula Weight: 788.87
MOL File: 144110-38-3.mol

More

Less

(2R,5S)-5-AMINO-8-GUANIDINO-4-OXO-2-P-HYDROXYPHENYLMETHYLOCTANOIC ACID HEMISULFATE MONOHYDRATE Property

storage temp.: −20°C
solubility: ≤0.2mg/ml in DMSO
form: White to yellow powder

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 18506
Product name: Arphamenine B (hemisulfate)
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 18506
Product name: Arphamenine B (hemisulfate)
Purity: ≥95%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 18506
Product name: Arphamenine B (hemisulfate)
Purity: ≥95%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

TRC

Product number: A771600
Product name: ArphamenineBHemisulfate
Packaging: 10mg
Price: $235
Updated: 2021/12/16

ApexBio Technology

Product number: C4189
Product name: ArphamenineB(hemisulfate)
Packaging: 10mg
Price: $321
Updated: 2021/12/16

More

Less

(2R,5S)-5-AMINO-8-GUANIDINO-4-OXO-2-P-HYDROXYPHENYLMETHYLOCTANOIC ACID HEMISULFATE MONOHYDRATE Chemical Properties,Usage,Production

Uses

Arphamenine B Hemisulfate is a Zn2+-dependent exopeptidase that selectively removes arginine and/or lysine from the amino terminus of peptide substrates. This enzyme is a metalloprotease commonly found on the surface of mammalian cells, including macrophages and lymphocytes. Arphamenine B Hemisulfate is an aminopeptidase B inhibitor first isolated from bacteria. Like the aminopeptidase inhibitors bestatin and amastatin , arphamenine B enhances immune responses. Arphamenine B Hemisulfate is commonly used to characterize novel proteases.[Cayman Chemical]

Biological Activity

arphamenine b is a specific inhibitor of aminopeptidase b first isolated from bacteria [1]. aminopeptidase b (ap-b) is a zn2+-dependent exopeptidase which selectively removes arg and/or lys residues from the n terminus of several peptide substrates. aminopeptidase b has been involved in processing events occurring either during its intracellular transport along the secretory pathway or at the plasma membrane level [2].

in vitro

arphamenine b inhibited the activity of aminopeptidase enzyme with an ic50 value of 9.0 μm [2]. arphamenine b strongly inhibited transport by the oligopeptide/h+ symporter with the ec50 values of 15 to 67 μm. arphamenine at concentration 100 μm acted as either ineffective or weak inhibitor of membrane-associated hydrolysis [4]. arphamenine selectively suppressed dipeptide hydrolysis [4].

References

[1] umezawa h, aoyagi t, ohuchi s, et al. arphamenines a and b, new inhibitors of aminopeptidase b, produced by bacteria[j]. the journal of antibiotics, 1983, 36(11): 1572-1575.
[2] balogh a, cadel s, foulon t, et al. aminopeptidase b: a processing enzyme secreted and associated with the plasma membrane of rat pheochromocytoma (pc12) cells[j]. journal of cell science, 1998, 111(2): 161-169.
[3] sajid m, isaac r e, harrow i d. purification and properties of a membrane aminopeptidase from ascaris suum muscle that degrades neuropeptides af1 and af2[j]. molecular and biochemical parasitology, 1997, 89(2): 225-234.
[4] daniel h, adibi s a. functional separation of dipeptide transport and hydrolysis in kidney brush border membrane vesicles[j]. the faseb journal, 1994, 8(10): 753-759.

(2R,5S)-5-AMINO-8-GUANIDINO-4-OXO-2-P-HYDROXYPHENYLMETHYLOCTANOIC ACID HEMISULFATE MONOHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(2R,5S)-5-AMINO-8-GUANIDINO-4-OXO-2-P-HYDROXYPHENYLMETHYLOCTANOIC ACID HEMISULFATE MONOHYDRATE Suppliers

China 27 Germany 1 Japan 1 Switzerland 3 United States 6 USA 1 Global 39

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30239
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44806
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29902
Advantage: 58

Shanghai Yiyan Biotechnology Co. , Ltd.

Tel: 021-69985186 13611928337
Email: 3427709316@qq.com
Country: China
ProdList: 7979
Advantage: 58

Shanghai Zhiyun Biotechnology Co., Ltd

Tel: 13119135307
Email: 3809801531@qq.com
Country: China
ProdList: 2767
Advantage: 58

SUZHOU SENFEIDA CHEMICAL CO.,LTD

Tel: +86-0512-83500002 +8615195660023
Email: sales@senfeida.com
Country: China
ProdList: 23046
Advantage: 58

Shenzhen Nexconn Pharmatechs Ltd

Tel: +86-755-89396905 +86-15013857715
Email: admin@nexconn.com
Country: China
ProdList: 10311
Advantage: 58

Shenzhen Xinbosheng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: service@neobioscience.com
Country: CHINA
ProdList: 6151
Advantage: 58

Beijing Bai Ao Si Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: yangmei@bioneeds.net
Country: CHINA
ProdList: 6999
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6936
Advantage: 58

Shanghai Minmin Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1914109725@qq.com
Country: CHINA
ProdList: 6518
Advantage: 58

Shanghai Gantu Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 1920192055@qq.com
Country: CHINA
ProdList: 1843
Advantage: 58

Beijing Bolide Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1985563437@qq.com
Country: CHINA
ProdList: 6158
Advantage: 58

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6025
Advantage: 58

Beijing Taize Jiaye Technology Development Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6050
Advantage: 58

Shanghai Ziqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2453006496@qq.com
Country: CHINA
ProdList: 6184
Advantage: 58

Boao Pike

Tel: --
Fax: --
Email: lyn@biopike.com.cn
Country: CHINA
ProdList: 6629
Advantage: 58

Beijing Shengke Boyuan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 978560024@qq.com
Country: CHINA
ProdList: 6005
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6973
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

Morning Student Science and Technology (Guangzhou) Co., Ltd.

Tel: --
Fax: --
Email: chenxue_gz@163.com
Country: CHINA
ProdList: 6600
Advantage: 58

Shanghai Yaoyun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 912529879@qq.com
Country: CHINA
ProdList: 6835
Advantage: 58

Beijing Luyuan Bird Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 15810802415@139.com
Country: CHINA
ProdList: 6750
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

144110-38-3, (2R,5S)-5-AMINO-8-GUANIDINO-4-OXO-2-P-HYDROXYPHENYLMETHYLOCTANOIC ACID HEMISULFATE MONOHYDRATERelated Search:

ARPHAMENINE A, INHIBITOROF AMINOPEPTIDASE B (2R,5S)-5-AMINO-8-GUANIDINO-4-OXO-2-P-HYDROXYPHENYLMETHYLOCTANOIC ACID HEMISULFATE MONOHYDRATE ARPHAMENINE A SULFATE 5-Aminolevulinic acid ALPHA-METHYLLEVULINIC ACID ARPHAMENINE B SULFATE 4-OXOHEPTANOIC ACID Agmatine sulfate Guanidine sulfate 1-OCTYLGUANIDINE HEMISULFATE 97 4-OXOOCTANOIC ACID 1-METHYLGUANIDINE SULFATE ARPHAMENINE A HEMISULFATE SALT,arphamenine A hemisulfate,ARPHAMENINE A HEMISULFATE MONOHYDRATE,ARPHAMENINE A N-ETHYLGUANIDINIUM SULFATE (+/-)-2-AMINOHEPTANE SULFATE

(R)-α-[(3S)-3-Amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-4-hydroxybenzenepropanoic acid

Arphamenine B hemisulfate salt hydrate

ARPHAMENINE B

ARPHAMENINE B HEMISULFATE MONOHYDRATE

(2R,5S)-5-AMINO-8-GUANIDINO-4-OXO-2-P-HYDROXYPHENYLMETHYLOCTANOIC ACID, HEMISULFATE

(2R,5S)-5-AMINO-8-GUANIDINO-4-OXO-2-P-HYDROXYPHENYLMETHYLOCTANOIC ACID HEMISULFATE MONOHYDRATE

(2R,5S)-5-AMINO-8-GUANIDINO-4-OXO-2-P-HYDROXYPHENYLMETHYLOCTANOIC ACID (SULFATE FORM)

ARPHAMENINE B HEMISULFATE HYDRATE*FROM MICROBIAL SOU

arphamenine B hemisulfate

(2R,5S)-5-Amino-8-guanido-4-oxo-2-p-hydroxyphenylmethyloctanoic acid

Arphamenine B hydrate hemisulfate salt

(2S,5R)-5-amino-8-(diaminomethylideneamino)-2-[(4-hydroxyphenyl)methyl]-4-oxooctanoic acid

5-amino-8-(diaminomethylideneamino)-2-[(4-hydroxyphenyl)methyl]-4-oxooctanoic acid

144110-38-3

C16H24N4O412H2SO4

C32H50N8O12S