ChemicalBook > CAS DataBase List > 6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride

6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride

Product Name: 6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride
CAS No.: 181632-25-7
Chemical Name: 6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride
Synonyms: CS-602;SB 242084;SB-242084/SB242084;dihydrochloride hydrate;SB 242084, 10 mM in DMSO;SB 242084 Dihydrochloride Hydrate;SB242084 hydrate dihydrochloride;SB 242084 Hydrochloride - CAS 181632-25-7 - Calbiochem;6-CHLORO-2,3-DIHYDRO-5-METHYL-N-[6-[(2-METHYL-3-PYRIDINYL)OXY];6-chloro-5-Methyl-N-(6-(2-Methylpyridin-3-yloxy)pyridin-3-yl)indoline-1-carboxaMide
CBNumber: CB02102836
Molecular Formula: C21H19ClN4O2
Formula Weight: 394.85
MOL File: 181632-25-7.mol

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6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride Property

Melting point:: 181-183℃
Boiling point:: 620.1±55.0 °C(Predicted)
Density: 1.362±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble15mg/mL, clear
pka: 12.47±0.20(Predicted)
form: powder
color: white to beige
InChI: InChI=1S/C21H19ClN4O2/c1-13-10-15-7-9-26(18(15)11-17(13)22)21(27)25-16-5-6-20(24-12-16)28-19-4-3-8-23-14(19)2/h3-6,8,10-12H,7,9H2,1-2H3,(H,25,27)
InChIKey: GCMNSEILNIPNSX-UHFFFAOYSA-N
SMILES: N1(C(NC2=CC=C(OC3=CC=CN=C3C)N=C2)=O)C2=C(C=C(C)C(Cl)=C2)CC1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.06417
Product name: SB 242084 Hydrochloride - CAS 181632-25-7 - Calbiochem
Packaging: 10mg
Price: $207
Updated: 2025/07/31

Sigma-Aldrich

Product number: S8061
Product name: SB 242084 dihydrochloride hydrate
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $949
Updated: 2022/05/15

Sigma-Aldrich

Product number: S8061
Product name: SB 242084 dihydrochloride hydrate
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $3280
Updated: 2022/05/15

Tocris

Product number: 2901
Product name: SB242084
Purity: ≥99%(HPLC)
Packaging: 10
Price: $225
Updated: 2021/12/16

Tocris

Product number: 2901
Product name: SB242084
Purity: ≥99%(HPLC)
Packaging: 50
Price: $942
Updated: 2021/12/16

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6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

SB 242084 is a 5-HT2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. SB 242084 displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors.SB 242084 os a brain penetrant; exerts anxiolytic-like activity.

Definition

ChEBI: 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;dihydrochloride is an organic molecular entity, an indole alkaloid and a pyridine. It has a role as a receptor modulator.

Biological Activity

5-HT 2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT 2A and 5-HT 2B receptors respectively. Also displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors. Brain penetrant; exerts anxiolytic-like activity.

Biochem/physiol Actions

SB 242084 is a potent and selective antagonist of 5-HT2C receptor. It increases the basal activity of dopaminergic neurons and affects the behavioral responses mediated by 5-HT2C such as mesolimbic neuron activity and food intake.3,4,5

6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride Suppliers

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181632-25-7, 6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochlorideRelated Search:

1-Methylpyrrole N-Methylaniline 2-Methylaminoethanol N-Methylbenzamide N-Methyldiethanolamine 6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride 1-(3-CHLORO-4-METHYLPHENYL)-3-METHYLUREA 1-(3-CHLORO-4-METHYLPHENYL)UREA 6-CHLORO-2,3-DIHYDRO-1H-INDOLE 6-(3-PYRIDYLOXY)PYRIDIN-3-AMINE 5-Chloro-2-methylphenylurea 6-CHLORO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE 6-Chloro-5-methylindoline

SB242084 hydrate dihydrochloride

6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamidedihydrochloride

SB 242084

SB-242084/SB242084

6-Chloro-5-methyl-N-(6-((2-methylpyridin-3-yl)oxy)pyridin-3-yl)indoline-1-carboxamide dihydrochlo

6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide dihydrochloride hydrate

6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline dihydrochloride hydrate

6-Chloro-2,3-dihydro-5-Methyl-N-[6-[(2-Methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxaMide Dihydrochloride Hydrate

SB 242084 Dihydrochloride Hydrate

6-CHLORO-2,3-DIHYDRO-5-METHYL-N-[6-[(2-METHYL-3-PYRIDINYL)OXY]

dihydrochloride hydrate

6-chloro-5-Methyl-N-(6-(2-Methylpyridin-3-yloxy)pyridin-3-yl)indoline-1-carboxaMide dihydrochloride

6-chloro-5-Methyl-N-(6-(2-Methylpyridin-3-yloxy)pyridin-3-yl)indoline-1-carboxaMide

6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide

6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride

6-Chloro-5-methyl-N-(6-((2-methylpyridin-3-yl)oxy)pyridin-3-yl)indoline-1-carboxamide dihydroc

1H-Indole-1-carboxamide, 6-chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-

SB 242084 Hydrochloride - CAS 181632-25-7 - Calbiochem

CS-602

6-chloro-5-methyl-N-{6-[(2-methylpyridin-3-yl)oxy] pyridin-3-yl}-2,3-dihydro-1H-indole-1-carboxamide

6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride

Serotonin Receptor,SB 242084,inhibit,5-HT Receptor,Inhibitor,SB-242084,5-hydroxytryptamine Receptor,SB242084

SB 242084, 10 mM in DMSO

181632-25-7

C21H19ClN4O22HCl