ChemicalBook > CAS DataBase List > 4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine

4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine

Product Name
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine
CAS No.
6975-75-3
Chemical Name
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine
Synonyms
ILK-IN-3;ILK-IN-3, 10 mM in DMSO;antitumor,Integrin,inhibit,ILK,Inhibitor,ILK IN 3,ILKIN3;1H-Pyrazole-3,5-diamine, 4-[2-(4-methoxyphenyl)diazenyl]-;4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine;3-amino-4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazol-5-ylamine
CBNumber
CB02111670
Molecular Formula
C10H12N6O
Formula Weight
232.24
MOL File
6975-75-3.mol
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4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Property

storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: 83.33 mg/mL (358.81 mM)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0104348
Product name
ILK-IN-3
Purity
99.57%
Packaging
5mg
Price
$250
Updated
2021/12/16
Matrix Scientific
Product number
173325
Product name
3-Amino-4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazol-5-ylamine
Packaging
1g
Price
$316
Updated
2021/12/16
ChemScene
Product number
CS-0104348
Product name
ILK-IN-3
Purity
99.57%
Packaging
25mg
Price
$700
Updated
2021/12/16
Matrix Scientific
Product number
173325
Product name
3-Amino-4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazol-5-ylamine
Packaging
5g
Price
$810
Updated
2021/12/16
Matrix Scientific
Product number
173325
Product name
3-Amino-4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazol-5-ylamine
Packaging
10g
Price
$1170
Updated
2021/12/16
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4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Chemical Properties,Usage,Production

Biological Activity

QLT0267 is an orally active, potent and selective integrin-linked kinase (ILK) inhibitor (IC50 = 26 nM; selectivity: >1000-fold over CK2, CSK, DNA-PK, PIM1, PKB/AKT, PKC, >100-fold over ERK1, GSK3β, LCK, PKA, p70S6K, and RSK1/QLT, >10-fold over CDK1/2/5) th at inhibits ILK-dependent cellular signaling (IC50 in 2h = 1 μM against 20 nM EGF-induced pAKT Ser473 phosphorylation in Hth74 cells). QLT0267 treatment causes thyroid cancer cell cycle arrest and apoptosis, leading to anti-proliferation efficacy in cultures (IC50 <6 μM; NPA187, DRO, and K4 cell lines) and in mice in vivo (DRO xenografts-derived tumor growth; 50-100 mg/kg via daily p.o.).

4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Suppliers

China 20 Finland 1 Russia 1 United States 6 Global 28
Interbioscreen Ltd.
Tel
--
Fax
--
Email
screen@ibscreen.chg.ru
Country
Finland
ProdList
6176
Advantage
60

6975-75-3, 4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamineRelated Search:


  • 3-amino-4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazol-5-ylamine
  • 4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine
  • ILK-IN-3
  • 1H-Pyrazole-3,5-diamine, 4-[2-(4-methoxyphenyl)diazenyl]-
  • antitumor,Integrin,inhibit,ILK,Inhibitor,ILK IN 3,ILKIN3
  • ILK-IN-3, 10 mM in DMSO
  • 6975-75-3