Propargylglycine
- Product Name
- Propargylglycine
- CAS No.
- 58160-95-5
- Chemical Name
- Propargylglycine
- Synonyms
- propargylglycine;N-2-propyn-1-ylGlycine;Glycine,N-2-propyn-1-yl-;2-(Prop-2-ynylamino)acetic acid;Acetic acid, 2-(prop-2-ynylamino)-
- CBNumber
- CB02131126
- Molecular Formula
- C5H7NO2
- Formula Weight
- 113.11
- MOL File
- 58160-95-5.mol
Propargylglycine Property
- Melting point:
- 243 °C (decomp)
- Boiling point:
- 273.5±20.0 °C(Predicted)
- Density
- 1.150±0.06 g/cm3(Predicted)
- pka
- 2.18±0.10(Predicted)
- form
- Solid
- color
- Off-white to light yellow
- InChI
- InChI=1S/C5H7NO2/c1-2-3-6-4-5(7)8/h1,6H,3-4H2,(H,7,8)
- InChIKey
- XSJLQGMTIHCDSS-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CNCC#C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
Propargylglycine Chemical Properties,Usage,Production
Uses
N-Propargylglycine is an orally active irreversible inhibitor of proline dehydrogenase (PRODH). N-Propargylglycine has antitumor activity and can be used in the study of neurodegenerative diseases[1].
References
[1] Scott GK, et al. N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties. Amino Acids. 2021 Dec;53(12):1927-1939. DOI:10.1007/s00726-021-03012-9
Propargylglycine Preparation Products And Raw materials
Raw materials
Preparation Products
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