3-hydroxy-2,2-dimethylpropanenitrile
- Product Name
- 3-hydroxy-2,2-dimethylpropanenitrile
- CAS No.
- 19295-57-9
- Chemical Name
- 3-hydroxy-2,2-dimethylpropanenitrile
- Synonyms
- 3-hydroxy-2,2-dimethylpropanenitrile;3-hydroxy-2,2-dimethyl-propionitrile;propanenitrile, 3-hydroxy-2,2-dimethyl-
- CBNumber
- CB02133418
- Molecular Formula
- C5H9NO
- Formula Weight
- 99.13
- MOL File
- 19295-57-9.mol
3-hydroxy-2,2-dimethylpropanenitrile Property
- Boiling point:
- 86-87 °C(Press: 18 Torr)
- Density
- 0.971±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 13.75±0.10(Predicted)
- Appearance
- Colorless to off-white Solid-liquid mixture
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H295570
- Product name
- 3-Hydroxy-2,2-dimethylpropanenitrile
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- H295570
- Product name
- 3-Hydroxy-2,2-dimethylpropanenitrile
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 041011
- Product name
- 3-Hydroxy-2,2-dimethylpropanenitrile
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- CHM0085746
- Product name
- 3-HYDROXY-2,2-DIMETHYLPROPANENITRILE
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $682
- Updated
- 2021/12/16
- Product number
- CHM0085746
- Product name
- 3-HYDROXY-2,2-DIMETHYLPROPANENITRILE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $750.75
- Updated
- 2021/12/16
3-hydroxy-2,2-dimethylpropanenitrile Chemical Properties,Usage,Production
Synthesis
1572-98-1
19295-57-9
The general procedure for the synthesis of 3-hydroxy-2,2-dimethylpropionitrile from ethyl 2-cyano-2-methylpropionate was as follows: 1) Dissolve ethyl 2-cyano-2-methylpropionate (5.0 g, 35.4 mmol) in a solvent mixture of tetrahydrofuran (40 mL) and water (100 mL). 2) Sodium borohydride (4.47 g, 106 mmol) was added slowly and the reaction mixture was stirred at room temperature for 3 hours. 3) Upon completion of the reaction, 6N hydrochloric acid was slowly added to the mixture to quench the reaction. 4) The reaction mixture was extracted with ethyl acetate and the organic phases were combined. 5) The organic phase was washed with water, dried over anhydrous magnesium sulfate, filtered and passed through a small amount of silica gel column. 6) The filtrate was concentrated under pressure to give the title compound 3-hydroxy-2,2-dimethylpropionitrile (3.4 g, 97% yield) as an oil. The product was characterized by 1H-NMR (CDCl3): δ 1.36 (6H, s), 3.58 (2H, s).
References
[1] Patent: US2009/156582, 2009, A1. Location in patent: Page/Page column 35
[2] Patent: EP1847531, 2007, A1. Location in patent: Page/Page column 51
[3] Patent: EP1717238, 2006, A1. Location in patent: Page/Page column 61
[4] Patent: WO2017/48675, 2017, A1. Location in patent: Paragraph 0434
[5] Patent: CN106478651, 2017, A. Location in patent: Paragraph 0900; 0901; 0902
3-hydroxy-2,2-dimethylpropanenitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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