Carisoprodol

Product Name: Carisoprodol
CAS No.: 78-44-4
Chemical Name: Carisoprodol
Synonyms: RELA;CARISOPRODO;Carbamic acid, (1-methylethyl)-, 2-[[(aminocarbonyl)oxy]methyl]-2-methylpentyl ester;NFKB3;Apesan;Arusal;Mioril;Sanoma;cb8019;Flexal
CBNumber: CB0215440
Molecular Formula: C12H24N2O4
Formula Weight: 260.33
MOL File: 78-44-4.mol

More

Less

Carisoprodol Property

Melting point:: 92-92°C
Boiling point:: 403.59°C (rough estimate)
Density: 1.1035 (rough estimate)
refractive index: 1.4560 (estimate)
storage temp.: 2-8°C
solubility: Very slightly soluble in water, freely soluble in acetone, in alcohol and in methylene chloride.
form: Solid
pka: pKa 4.2 (Uncertain)
color: White to Off-White
Water Solubility: <0.1 g/100 mL at 19.5 ºC
BCS Class: 2/4
CAS DataBase Reference: 78-44-4(CAS DataBase Reference)
NIST Chemistry Reference: Carisoprodol(78-44-4)
EPA Substance Registry System: Carisoprodol (78-44-4)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
RTECS: FB3325000
HS Code: 29224999
Hazardous Substances Data: 78-44-4(Hazardous Substances Data)
Toxicity: LD50 in mice, rats (mg/kg): 2340, 1320 orally; 980, 450 i.p. (Berger)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1096600
Product name: Carisoprodol
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 1g
Price: $581
Updated: 2024/03/01

TCI Chemical

Product number: C3573
Product name: Carisoprodol
Packaging: 5G
Price: $82
Updated: 2022/04/27

TCI Chemical

Product number: C3573
Product name: Carisoprodol
Packaging: 25G
Price: $318
Updated: 2022/04/27

Cayman Chemical

Product number: ISO60206
Product name: Carisoprodol (CRM)
Packaging: 1mg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 30778
Product name: Carisoprodol
Packaging: 50mg
Price: $70
Updated: 2024/03/01

More

Less

Carisoprodol Chemical Properties,Usage,Production

Description

Carisoprodol (Item No. 30778) is an analytical reference standard categorized as a skeletal muscle relaxant. It also has sedative properties. Carisoprodol is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.

Description

Carisoprodol (CRM) (Item No. ISO60206) is a certified reference material categorized as a skeletal muscle relaxant. It also has sedative properties. Carisoprodol is regulated as a Schedule IV compound in the United States. Carisoprodol (CRM) (Item No. ISO60206) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.

Chemical Properties

White Solid

Originator

Soma,Wallace,US,1959

Uses

Carisoprodol suppresses interneuronal action of reticular formation of the spinal cord. It is used as an adjuvant drug for loss of flexibility of skeletal muscle as well as for relieving pain caused therein. Synonyms of this drug are rela, soma, carisoma, and sanoma.

Uses

Muscle relaxant (skeletal)
Carisoprodol has an onset of action of ca. 30min and a duration of 4–6h. It is administered orally. Presumably, it acts by inhibiting interneuronal activity in the spinal cord and the brainstem reticular formation. Clinically effective doses are accompanied by drowsiness or dizziness; its mechanism may involve sedation.Its CNS depressant effects are additive with those of ethanol and other psychotropic agents. Carisoprodol has a low potential for drug dependence.

Uses

For the relief of discomfort associated with acute, painful, musculoskeletal conditions.

Definition

ChEBI: A carbamate ester that is the mono-N-isopropyl derivative of meprobamate (which is a significant metabolite). Carisoprodol interrupts neuronal communication within the reticular formation and spinal cord, resulting in sedation and alter tion in pain perception. It is used as a muscle relaxant in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm.

Preparation

Carisoprodol is Prepared by reaction of 2-methyl-2-propyl-1,3-pro-panediol with phosgene and ammonium hydroxide, then with isopropyl isocyanate.

Manufacturing Process

A cooled 10% solution of 1 mol of phosgene in toluene was added with stirring to a cooled solution of 1 mol of 2-methyl-2-propyl-1,3-propanediol and 2 mols of dimethylaniline also dissolved in toluene, at such a rate that the temperature of the mixture was maintained at about 25°C. The mixture was allowed to remain at this temperature for several hours, then cooled and extracted with cold 5% hydrochloric acid solution to remove the dimethylaniline. The toluene layer was dried using a suitable drying agent and the 2-methyl-2-propyl-3-hydroxypropyl chlorocarbonate used in subsequent reactions in the form of its solution in anhydrous toluene.
A quantity of solution obtained as described containing 0.1 mol of the chlorocarbonate was treated with 0.2 mol of anhydrous isopropylamine and allowed to react at ordinary room temperature. The solution was cooled, extracted with dilute hydrochloric acid and the organic layer concentrated by evaporation of the solvent. The crude monocarbamate was purified by distilling at 86° to 88°C at about 0.01 mm. It was a clear, viscous liquid.
21.7 g (0.1 mol) of N-isopropyl-2-methyl-2-propyl-3-hydroxypropylcarbamate and 7.5 g (0.11 mol) of anhydrous sodium cyanate are stirred in 200 ml anhydrous chloroform in a suitable vessel equipped with a gas inlet tube,stirrer and thermometer. While cooling the vessel, anhydrous hydrogen chloride is passed into the stirred mixture slowly for 5 hours maintaining the temperature between 0° and 5°C. Alternatively ethyl urethane in the presence of aluminum isopropylate as a catalyst may be used in place of the sodium cyanates and HCl. The mixture is then allowed to stand at room temperature overnight.
The solid material is separated by filtration and the chloroform solution concentrated to an oil under reduced pressure. The oil is dissolved in 50 ml of trichloroethylene, the solution treated with charcoal, filtered and the filtrate added to 125 ml of hexane. The crystalline material which forms on standing at refrigerator temperature is removed by filtration, washed with light petroleum ether and dried at about 50°C. Approximately 20 g of product are obtained. On recrystallizing from trichloroethylene-hexane, 17.8 g of purified compound are obtained, MP 89° to 91°C.

brand name

Rela (Schering); Soma (Medpointe).

Therapeutic Function

Muscle relaxant

General Description

Carisoprodol, N-isopropyl-2-methyl-2-propyl-1,3-propanediol dicarbamate, 2-methyl-2-propyl-1,3-propanediol carbamate isopropylcarbamate(Soma), is the mono-N-isopropyl–substituted relative ofmeprobamate. The structure is given in the discussion ofmeprobamate. It is indicated in acute skeletomuscular conditionscharacterized by pain, stiffness, and spasm. As canbe expected, a major side effect of the drug is drowsiness.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Carisoprodol is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.

Health Hazard

SYMPTOMS: The most common symptoms of exposure to Carisoprodol are drowsiness and hives. Other symptoms may include nausea, vomiting, epigastric distress, vertigo, ataxia, tremors, agitation, irritability, headache, insomnia, fainting, hiccups, visual disturbances, asthma, fever, hypotension, excitement and paralysis.

Fire Hazard

Flash point data for Carisoprodol are not available, but Carisoprodol it probably combustible.

Synthesis

Carisoprodol, N-iso-propyl-2-methyl-2-propyl-1,3-propanediol (15.3.12), is synthesized by reacting 2-methyl-2-propylpropanediol-1,3 dicarbamate with 1 mol of phosgene, forming the chloroformate (15.3.10), from which carbamate (15.3.11) is formed by reacting it with isopropylamine. Reacting this with either urethane or sodium cyanate gives carisoprodol (15.3.12).

Carisoprodol Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Carisoprodol Suppliers

Americas 1 Austria 1 Belgium 2 Brazil 1 Canada 4 China 159 Cyprus 1 Europe 3 France 5 Germany 4 India 79 Indonesia 1 Italy 2 Japan 1 Nepal 1 South Korea 1 Spain 7 Switzerland 2 United Arab Emirates 1 United Kingdom 10 United States 34 Venezuela 1 Global 321

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

TOPCHEM PHARMACEUTICALS LTD

Tel: --
Fax: --
Email: Vinchem@vinchem.com
Country: United States
ProdList: 140
Advantage: 58

International Specialty Chemicals & Pharmaceuticals, Inc. (ISC&P)

Tel: --
Fax: --
Email: info@ischem.com
Country: United States
ProdList: 77
Advantage: 58

PlusPharma Incorporated

Tel: --
Fax: --
Email: info@pluspharm.com
Country: United States
ProdList: 53
Advantage: 58

ZETA Pharmaceuticals, L.L.C.

Tel: --
Fax: --
Email: zeta@zetapharm.com
Country: United States
ProdList: 102
Advantage: 58

BASF SE

Tel: --
Fax: --
Email: jennifer.moore-braun@basf.com
Country: United States
ProdList: 285
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

Crescent Chemical Co., Inc.

Tel: --
Fax: --
Email: sales@creschem.com
Country: United States
ProdList: 4597
Advantage: 68

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Cerilliant Corporation

Tel: --
Fax: --
Email: techserv@cerilliant.com
Country: United States
ProdList: 1629
Advantage: 69

Medical Isotopes

Tel: --
Fax: --
Email: stohler@medicalisotopes.com
Country: United States
ProdList: 6181
Advantage: 68

SST Corporation

Tel: --
Fax: --
Email: info@sst-corp.com
Country: United States
ProdList: 237
Advantage: 38

Spectrum Chemicals & Laboratory Products

Tel: --
Fax: --
Email: sales@spectrumchemical.com
Country: United States
ProdList: 6699
Advantage: 77

Hawkins, Inc.

Tel: --
Fax: --
Email: ir@hawkinsinc.com
Country: United States
ProdList: 235
Advantage: 68

Hawkins, Inc.

Tel: --
Fax: --
Email: ir@hawkinsinc.com
Country: United States
ProdList: 212
Advantage: 30

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

Advance Scientific & Chemical

Tel: --
Fax: --
Email: sales@advance-scientific.com
Country: United States
ProdList: 6419
Advantage: 71

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

SynFine Research

Tel: --
Fax: --
Email: research@synfine.com
Country: United States
ProdList: 1024
Advantage: 68

MP Biomedicals, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6561
Advantage: 81

Alltech Associates, Inc.

Tel: --
Fax: --
Email: alltech@alltechemail.com
Country: United States
ProdList: 419
Advantage: 60

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

Ceres Chemical Co. Inc.

Tel: --
Fax: --
Email: chemceres@aol.com
Country: United States
ProdList: 50
Advantage: 51

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

American Custom Chemicals Corporation

Tel: --
Fax: --
Email: sales@acccorporation.com
Country: United States
ProdList: 6820
Advantage: 51

More

Less

View Lastest Price from Carisoprodol manufacturers

Dorne Chemical Technology co. LTD

Product: Carisoprodol 78-44-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Carisoprodol 78-44-4
Price: US $1.00/Kg/Bag
Min. Order: 1KG
Purity: 98.0%-102.0%,USP35
Supply Ability: 1ton/month
Release date: 2021-06-01

hebei hongtan Biotechnology Co., Ltd

Product: Carisoprodol 78-44-4
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000kg
Release date: 2024-05-13

78-44-4, CarisoprodolRelated Search:

Methylparaben Diethyl phthalate Isopropyl acetate Acetonitrile Methyl acrylate Methanol Isopropyl alcohol Propyl butyrate Propyl gallate ISOPROPYL LAURATE Tris(trimethylsilyl)phosphate Tris(hydroxymethyl)nitromethane Methyl Lorbamate Nisobamate n-Butyl carbamate Meprobamate Carisoprodol

isopropylcarbamic acid ester with 2-(hydroxymethyl)-2-methylpentyl carbamate

CARISOPRODOL

n-isopropyl 2-methyl-2-propyl-1,3-propanediol dicarbamate

2-Methyl-2-Propyl-1,2-Propanediol

Carisoprodol CIV (1 g)

(1-Methylethyl)carbamic acid 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester

(1-methylethyl)-carbamicaci2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl

(1-methylethyl)carbamicacid2-(((aminocarbonyl)oxy)methyl)-2-methylpentyles

1,3-Propanediol, 2-methyl-2-propyl-, carbamate isopropylcarbamate

2-Methyl-2-propyl-1,3-propanediol carbamate isopropylcarbamate

2-methyl-2-propyl-1,3-propanediolcarbamateisopropylcarbamate

3-propanediol,2-methyl-2-propyl-carbamateisopropylcarbamate(ester)

Apesan

Arusal

Atonalyt

Brianil

isopropyl-carbamicaci2-(hydroxymethyl)-2-methylpentylestercarbamate(es

isopropylmeprobamate

Isoprotan

Isoprotane

Isoprothane

Izoprotan

Mediquil

Mioartrina

Miolisodal

Miolisodol

Mioratrina

Mioril

Mioriodol

NCI-C56235

Nospasm

RELA

Relasom

Sanoma

SCH 7307

sch7307

Skutamil

Somadril

Somalgit

Somanil

Stialgin

Tonolyt isopropyl meprobamate

2-carbamoyloxymethyl-2-methylpentyl isopropylcarbamate

Carisoprodol RM

Calenfa

Caprodat

Carbamic acid, (1-methylethyl)-, 2-[[(aminocarbonyl)oxy]methyl]-2-methylpentyl ester

Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentylisopropyl carbamate

Carbamic acid, ester with 2-methyl-2-propyl-1,3-propanediol isopropylcarbamate

Carbamic acid, isopropyl-, 2-(hydroxymethyl)-2-methylpentyl ester carbamate

Carbamic acid, isopropyl-, 2-(hydroxymethyl)-2-methylpentyl ester carbamate (ester)

carbamicacid,esterwith2-(hydroxymethyl)-2-methylpentylisopropylcarbamate

carbamicacid,esterwith2-methyl-2-propyl-1,3-propanediolisopropylcarbamat

Carisol

Carisoma

Carisoprodate

Carisoprodatum

Carlsodol