4-(MORPHOLINOMETHYL)BENZONITRILE

Product Name: 4-(MORPHOLINOMETHYL)BENZONITRILE
CAS No.: 37812-51-4
Chemical Name: 4-(MORPHOLINOMETHYL)BENZONITRILE
Synonyms: USAF A-3730;BUTTPARK 98\57-96;4-(Morpholinomethyl);N-(4-CYANOBENZYL)MORPHOLINE;4-(MORPHOLINOMETHYL)BENZONITRILE;4-MORPHOLIN-4-YLMETHYLBENZONITRILE;alpha-(4-morpholinyl)-p-tolunitril;4-(4-MORPHOLINYLMETHYL)BENZONITRILE;4-(4-morpholinylmethyl)-benzonitril;alpha-(4-morpholinyl)-p-tolunitrile
CBNumber: CB0217000
Molecular Formula: C12H14N2O
Formula Weight: 202.25
MOL File: 37812-51-4.mol

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4-(MORPHOLINOMETHYL)BENZONITRILE Property

Melting point:: 84-89°C
Boiling point:: 332.4±32.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 5.94±0.10(Predicted)
form: Crystalline Powder
color: White to light yellow
CAS DataBase Reference: 37812-51-4

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Safety

HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: OTV000427
Product name: 4-(Morpholinomethyl)benzonitrile
Packaging: 250 mg
Price: $107
Updated: 2025/07/31

TRC

Product number: M725318
Product name: 4-(Morpholinomethyl)benzonitrile
Packaging: 25mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H37-1-2K
Product name: 4-(Morpholinomethyl)benzonitrile
Packaging: 1g
Price: $80
Updated: 2021/12/16

AK Scientific

Product number: Z4676
Product name: 4-(Morpholinomethyl)benzonitrile
Packaging: 1g
Price: $93
Updated: 2021/12/16

ChemScene

Product number: CS-0093031
Product name: 4-(Morpholinomethyl)benzonitrile
Packaging: 5g
Price: $95
Updated: 2021/12/16

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4-(MORPHOLINOMETHYL)BENZONITRILE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder

Synthesis

110-91-8

17201-43-3

37812-51-4

1. 4-Cyanobenzyl bromide (2.28 g, 11.6 mmol) was dissolved in 25 mL of anhydrous acetonitrile under nitrogen protection. 2. To the above solution, morpholine (1.5 mL, 17.4 mmol) and potassium carbonate (0.69 g, 5 mmol) were added sequentially. 3. Stir the reaction mixture for 30 minutes at room temperature. 4. 4. Upon completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate. 5. The organic layers were combined, dried over anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. 6. 6. The crude product was purified by column chromatography (eluent: hexane-30% ethyl acetate/hexane) to give 4-(4-morpholinylmethyl)benzonitrile. 7. The product was a white solid. 7. The product was a white solid in 96% yield. 8. 8. 1H NMR (400 MHz, CDCl3) δ 7.61 (d, J = 7.9 Hz, 2H), 7.48 (d, J = 8.0 Hz, 2H), 3.71 (s, 4H), 3.55 (s, 2H), 2.44 (s, 4H); 13C NMR (100 MHz, CDCl3): 144.2, 132.5, 129.8, 119.2, 129.8, 119.2 129.8, 119.2, 111.3, 67.2, 63.1, 54.1.

References

[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 5, p. 1844 - 1857
[2] Patent: WO2012/69856, 2012, A1. Location in patent: Page/Page column 67
[3] European Journal of Medicinal Chemistry, 2018, vol. 152, p. 31 - 52
[4] Patent: WO2013/153357, 2013, A1. Location in patent: Page/Page column 20; 41; 42
[5] Patent: US2015/45354, 2015, A1. Location in patent: Paragraph 0251-0254

4-(MORPHOLINOMETHYL)BENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(MORPHOLINOMETHYL)BENZONITRILE Suppliers

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37812-51-4, 4-(MORPHOLINOMETHYL)BENZONITRILERelated Search:

4-(MORPHOLINOMETHYL)BENZONITRILE 4-[(2,6-dimethylmorpholin-4-yl)methyl]-3-fluorobenzonitrile 4-(2-AMINOMETHYL-MORPHOLIN-4-YLMETHYL)-BENZONITRILE DIHYDROCHLORIDE 3-fluoro-4-[(2-methylmorpholin-4-yl)methyl]benzonitrile 4-[(2-methylmorpholin-4-yl)carbonyl]benzonitrile 4-[(2-methylmorpholin-4-yl)methyl]benzonitrile 4-(MORPHOLIN-4-YLCARBONYL)BENZONITRILE 3-fluoro-4-(morpholin-4-ylmethyl)benzonitrile 4-[(2,6-dimethylmorpholin-4-yl)methyl]benzonitrile 4-[(2,6-dimethylmorpholin-4-yl)carbonyl]benzonitrile

4-(MORPHOLINOMETHYL)BENZONITRILE

4-MORPHOLIN-4-YLMETHYLBENZONITRILE

4-(4-MORPHOLINYLMETHYL)BENZONITRILE

p-Tolunitrile, alpha-(4-morpholinyl)-

4-MORPHOLIN-4-YLMETHYLBENZONITRILE, 95+%

USAF A-3730

4-(4-Morpholinylmethyl)benzonitrile,97%

4-(morpholin-4-ylmethyl)benzonitrile hydrochloride

benzonitrile, 4-(4-morpholinylmethyl)-

BUTTPARK 98\57-96

N-(4-CYANOBENZYL)MORPHOLINE

4-(4-morpholinylmethyl)-benzonitril

alpha-(4-morpholinyl)-p-tolunitril

alpha-(4-morpholinyl)-p-tolunitrile

4-(Morpholinomethyl)

37812-51-4

C12H14N2O

Aromatic Nitriles