6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one
- Product Name
- 6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one
- CAS No.
- 26246-41-3
- Chemical Name
- 6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one
- Synonyms
- K 251-1;Reticulol;Nsc 294978;6,8-Dihydroxy-7-methoxy-3-methylisocoumarin;6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one;1H-2-Benzopyran-1-one, 6,8-dihydroxy-7-methoxy-3-methyl-
- CBNumber
- CB02179856
- Molecular Formula
- C11H10O5
- Formula Weight
- 222.19
- MOL File
- 26246-41-3.mol
6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one Property
- Melting point:
- 193-193.5℃
- Boiling point:
- 473.2±45.0 °C(Predicted)
- Density
- 1.424±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 7.19±0.20(Predicted)
- form
- A powder
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 23148
- Product name
- Reticulol
- Purity
- >95%
- Packaging
- 500μg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 23148
- Product name
- Reticulol
- Purity
- >95%
- Packaging
- 1mg
- Price
- $146
- Updated
- 2024/03/01
- Product number
- 23148
- Product name
- Reticulol
- Purity
- >95%
- Packaging
- 5mg
- Price
- $679
- Updated
- 2024/03/01
- Product number
- R1650-35
- Product name
- Reticulol
- Packaging
- 1mg
- Price
- $426
- Updated
- 2021/12/16
- Product number
- R188508
- Product name
- Reticulol
- Packaging
- 250μg
- Price
- $85
- Updated
- 2021/12/16
6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one Chemical Properties,Usage,Production
Description
Reticulol is an isocoumarin derivative produced by certain species of Streptomyces that inhibits cAMP phosphodiesterase (IC50 = 41 μM). It also inhibits DNA topoisomerase I when used at a concentration of 45 μM in B16F10 melanoma cells. Reticulol has antifungal activity against T. mentagrophyes with a MIC of 1.8 μM. It is cytotoxic against A427 human lung and B16F10 mouse melanoma cells at concentrations of 25 and 200 μM, respectively, and inhibits lung metastasis in mice.
Uses
Reticulol is an isocoumarin metabolite produced by selected species of Streptomyces. Reticulol was first described as a potent inhibitor of cyclic nucleotide phosphodiesterase but more recent research has demonstrated a topoisomerase I inactivation mechanism. Reticulol also causes dose dependent inhibition of lung metastasis in the B16F10 melanoma model.
Uses
Reticulol is an isocoumarin metabolite shown to inactivate topoisomerase I.
storage
+4°C