ChemicalBook > CAS DataBase List > 4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID

4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID

Product Name
4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID
CAS No.
19741-14-1
Chemical Name
4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID
Synonyms
DAMPA;2,4-Apa;NSC 133723;Nsc 131463;NSC 131463 (DAMPA);Deoxyaminopteroic acid;Methotrexate metabolite;DAMPA hydrochloride hydrate;Methotrexate Impurity 5(EP-E);4-(((2,4-Diaminopteridin-6-yl)
CBNumber
CB0221021
Molecular Formula
C15H15N7O2
Formula Weight
325.33
MOL File
19741-14-1.mol
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4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID Property

Melting point:
255 °C (dec.)(lit.)
Boiling point:
689.3±65.0 °C(Predicted)
Density 
1.532
storage temp. 
2-8°C(protect from light)
solubility 
Aqueous Base, DMSO
form 
Solid
pka
4.63±0.10(Predicted)
color 
Dark Yellow to Very Dark Brown
Stability:
Hygroscopic
CAS DataBase Reference
19741-14-1
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Safety

Hazard Codes 
Xi
Risk Statements 
43-52/53
Safety Statements 
36/37
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H341Suspected of causing genetic defects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000664
Product name
Methotrexate impurity E
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
10 mg
Price
$236
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0000664
Product name
Methotrexate impurity E
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000664
Price
$220
Updated
2024/03/01
TRC
Product number
D136500
Product name
DAMPA
Packaging
500mg
Price
$1390
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
63906
Product name
DAMPA
Packaging
500mg
Price
$2200
Updated
2021/12/16
Biosynth Carbosynth
Product number
ID20780
Product name
4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoic acid
Packaging
100mg
Price
$270
Updated
2021/12/16
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4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

Brownish Yellow to Orange Solid

Uses

DAMPA is a Methotrexate (M260675) analog (1). DAMPA is an antitumor agent (2).

in vivo

Methotrexate metabolite (8.6-10.1 mg/kg, 200 mg/m2, i.v., 15 minutes) has pharmacokinetic properties of rapid clearance and extensive metabolism in adult male Rhesus monkeys (Macaca mulatta) (8.0-15.9 kg), with an average clearance rate of 1.9 l/kg/h and an average terminal half-life of 51 minutes[1].

4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID Suppliers

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View Lastest Price from 4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID manufacturers

Career Henan Chemical Co
Product
4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID 19741-14-1
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-02-04

19741-14-1, 4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACIDRelated Search:

Methotrexate γ-Methyl Ester Methotrexate Aminopterin Methotrexate α-Methyl Ester Methotrexate impurity N-(p-Aminobenzoyl)glutamic acid 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE L-Glutamic acid, N-[N-[N-[N-[4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-.gamma.-gluta myl]-L-.gamma.-glutamyl]-L-.gamma.-glutamyl]- Folic Acid Related Compound A/Calcium Formyltetrahydrofolate L-Glutamic acid der. 7-HYDROXY METHOTREXATE 4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID 4-Dimethylaminobenzoic acid 6-Methyl-2,4-pteridinediamine 4-(N-[2,4-DIAMINO-6-PTERIDINYLMETHYL]-AMINO)BENZOIC ACID SODIUM SALT 2,4-Diaminopteridine 4-Pteridinamine (9CI) 4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO]BENZOIC ACID HEMIHYDROCHLORIDE HYDRATE

  • 2,4-Diamino-N(10)-methylpteroic acid
  • 4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoic acid
  • Deoxyaminopteroic acid
  • N-10-Methyl-4-deoxy-4-aminopteroate
  • Nsc 131463
  • DAMPA
  • p-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoic acid
  • 4-[N-[(2,4-DiaMinopyriMido[4,5-b]pyrazin-6-yl)Methyl]-N- MethylaMino]benzoic Acid
  • 4-AMino-4-deoxy-10-Methylpteroic Acid
  • NSC 133723
  • Benzoic acid, 4-[[(2,4-diaMino-6-pteridinyl)Methyl]MethylaMino]-
  • NSC 131463 (DAMPA)
  • 4-{[(2,4-Diaminopteridin-6-yl)methyl]methylamino}benzoic acid
  • DAMPA hemihydrochloride hydrate
  • 4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID
  • 4-(((2,4-Diaminopteridin-6-yl)
  • 4-[[(2,4-Diamino-6-pteridinyl)methyl](methyl)amino]benzenecarboxylic acid
  • 2,4-Apa
  • 4-amino-4-deoxy-n-10-methylpteroicacid
  • 4-(N-(2,4-diamino-6-pteridinylme)-N-me-amino)benz
  • 4-[N-(2,4-Diamino-6-pteridinylmethyl)-N-methylamino]benzoic acid hemihydrochloride dihydrate
  • bis(4-((2,4-diaminopteridin-6-ylmethyl)methylamino)benzoic) acid hydrochloride tetrahydrate
  • 4-(N-(2,4-DIAMINO-6-PTERIDINYLME)-N-ME-A MINO)BENZOIC ACID HEMI-HCL 2 H20,
  • 4[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO
  • 4-[N-(2,4-Diamino-6-pteridinylmethyl)-N-methylamino]-benzoic acid hemihydro
  • diamino-6-pteridinylmethyl-N-methylaminobenzoic acid HCl
  • Methotrexate Impurity 5(EP-E)
  • Methotrexate metabolite
  • Methotrexate EP Impurity E/2,4-Diamino-N10-methylpterioc acid/4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzoic acid
  • DAMPA hydrochloride hydrate
  • Methotrexate EP Impurity E（Amethopterin EP Impurity E）
  • Methotrexate USP Related Compound E
  • 4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoicaci
  • Methotrexate metabolite (DAMPA)
  • 4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoic Acid (4-Amino-N10-methylpteroic Acid
  • Methotrexate metabolite, 10 mM in DMSO
  • 19741-14-1
  • C15H15N7O2
  • Quinazolines
  • Building Blocks
  • Heterocyclic Building Blocks
  • Bases & Related Reagents
  • Drug Analogues
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • API