4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide

ChemicalBook > CAS DataBase List > 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide

Product Name: 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide
CAS No.: 36707-00-3
Chemical Name: 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide
Synonyms: API-1;NSC 177223;API-1(NSC 177223);API-1, 10 mM in DMSO;4-Amino-5-oxo-8-pentofuranosyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide;4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide;Pyrido[2,3-d]pyrimidine-6-carboxamide, 4-amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-;4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide;4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide;TRAIL,API 1,PKB,Akt,Inhibitor,API-1,inhibit,Akt/PKB inhibitor,Protein kinase B,API1,Apoptosis
CBNumber: CB02264862
Molecular Formula: C13H15N5O6
Formula Weight: 337.29
MOL File: 36707-00-3.mol

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4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide Property

storage temp.: Store at RT
solubility: DMF: slightly soluble; DMSO: 2 mg/ml
form: powder
color: white to beige

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Safety

RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1342
Product name: API-1
Packaging: 5mg
Price: $160
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1342
Product name: API-1
Packaging: 25mg
Price: $552
Updated: 2022/05/15

Cayman Chemical

Product number: 22081
Product name: API-1
Purity: ≥98%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 22081
Product name: API-1
Purity: ≥98%
Packaging: 5mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 22081
Product name: API-1
Purity: ≥98%
Packaging: 10mg
Price: $270
Updated: 2024/03/01

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4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide Chemical Properties,Usage,Production

Uses

NSC 177223 is a Akt/protein kinase B inhibitor. It binds to pleckstrin homologous domain of Akt and blocks Akt membrane translocation. Treatment of cancer cells with NSC 177223 results in inhibition of the kinase activities and induction of cell growth arrest and apoptosis selectively in human cancer cells that harbor constitutively activated Akt.

storage

Store at RT

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide Suppliers

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36707-00-3, 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamideRelated Search:

NSC 177223

4-amino-8-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide

4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide

API-1

4-Amino-5-oxo-8-pentofuranosyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Pyrido[2,3-d]pyrimidine-6-carboxamide, 4-amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-

API-1(NSC 177223)

TRAIL,API 1,PKB,Akt,Inhibitor,API-1,inhibit,Akt/PKB inhibitor,Protein kinase B,API1,Apoptosis

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide

API-1, 10 mM in DMSO

36707-00-3

C13H15N5O6