3-FLUORO-5-HYDROXYBENZENEBORONIC ACID
- Product Name
- 3-FLUORO-5-HYDROXYBENZENEBORONIC ACID
- CAS No.
- 871329-82-7
- Chemical Name
- 3-FLUORO-5-HYDROXYBENZENEBORONIC ACID
- Synonyms
- 3-Borono-5-fluorophenol;(3-Fluoro-5-hydroxyphenyl);3-Fluoro-5-hydroxybenzeneboronic;3-FLUORO-5-HYDROXYPHENYLBORONIC ACID;3-FLUORO-5-HYDROXYBENZENEBORONIC ACID;B-(3-Fluoro-5-hydroxyphenyl)boronic acid;Boronic acid, B-(3-fluoro-5-hydroxyphenyl)-;3-Fluoro-5-hydroxyphenylboronic Acid (contains varying amounts of Anhydride);3-Fluoro-5-hydroxybenzeneboronic Acid (contains varying amounts of Anhydride)
- CBNumber
- CB0235875
- Molecular Formula
- C6H6BFO3
- Formula Weight
- 155.92
- MOL File
- 871329-82-7.mol
3-FLUORO-5-HYDROXYBENZENEBORONIC ACID Property
- Melting point:
- 54-62
- Boiling point:
- 380.0±52.0 °C(Predicted)
- Density
- 1.42
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- 7.23±0.10(Predicted)
- color
- White to Almost white
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C6H6BFO3/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,9-11H
- InChIKey
- RMBFBZIEXCTPDB-UHFFFAOYSA-N
- SMILES
- B(C1=CC(O)=CC(F)=C1)(O)O
- CAS DataBase Reference
- 871329-82-7
Safety
- WGK Germany
- WGK 3
- Hazard Note
- Harmful
- HS Code
- 2931900090
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CDS007717
- Product name
- 3-fluoro-5-hydroxybenzeneboronic acid
- Purity
- AldrichCPR
- Packaging
- 250MG
- Price
- $185
- Updated
- 2025/07/31
- Product number
- F0954
- Product name
- 3-Fluoro-5-hydroxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $142
- Updated
- 2025/07/31
- Product number
- F595343
- Product name
- 3-Fluoro-5-hydroxyphenylboronicacid
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 40303
- Product name
- 3-Fluoro-5-hydroxyphenylboronicacid,97-105%(Assaybytitration)
- Purity
- 97-105%(Assaybytitration)
- Packaging
- 1G
- Price
- $92.96
- Updated
- 2021/12/16
- Product number
- 6660-3-Z4
- Product name
- 3-Fluoro-5-hydroxybenzeneboronic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $66
- Updated
- 2021/12/16
3-FLUORO-5-HYDROXYBENZENEBORONIC ACID Chemical Properties,Usage,Production
Uses
suzuki reaction
Uses
3-Fluoro-5-hydroxybenzeneboronic acid is used as pharmaceutical intermediate.
Synthesis
609807-25-2
871329-82-7
Under nitrogen protection, (3-fluoro-5-methoxyphenyl)boronic acid (500 mg, 2.942 mmol) was dissolved in dichloromethane (15 mL) and cooled to 0°C. A dichloromethane solution of 1 M boron tribromide (14.7 mL, 14.7 mmol) was slowly added dropwise. The reaction mixture was stirred at room temperature for 3 h. The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was concentrated under reduced pressure. Water (15 mL) was added to the residue and the pH was adjusted to 2 with 1 M aqueous hydrochloric acid. the product was extracted with ethyl acetate (2 x 25 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give (3-fluoro-5-hydroxyphenyl)boronic acid (430 mg) as an off-white solid.
References
[1] Patent: WO2015/58084, 2015, A1. Location in patent: Paragraph 0222
3-FLUORO-5-HYDROXYBENZENEBORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-FLUORO-5-HYDROXYBENZENEBORONIC ACID manufacturers
- Product
- 3-FLUORO-5-HYDROXYBENZENEBORONIC ACID 871329-82-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg; 5kg; 100kg
- Release date
- 2019-07-03