ChemicalBook > CAS DataBase List > 2-Methylpyrazine

2-Methylpyrazine

Product Name
2-Methylpyrazine
CAS No.
109-08-0
Chemical Name
2-Methylpyrazine
Synonyms
Pyrazine, methyl-;METHYLPYRAZINE;3-Methylpyrazine;2-METHYL-1,4-DIAZINE;MPZ;FEMA 3309;FEMA 3616;Methylpiazine;methyl-pyrazin;FEMA NUMBER 3309
CBNumber
CB0237950
Molecular Formula
C5H6N2
Formula Weight
94.11
MOL File
109-08-0.mol
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2-Methylpyrazine Property

Melting point:
-29 °C (lit.)
Boiling point:
135 °C/761 mmHg (lit.)
Density 
1.03 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.504(lit.)
FEMA 
3309 | 2-METHYLPYRAZINE
Flash point:
122 °F
storage temp. 
2-8°C
solubility 
>20.87 mg/mL in EtOH with ultrasonic; >49.9 mg/mL in DMSO;
form 
Liquid
pka
1.45(at 27℃)
color 
Clear colorless to slightly yellow
Odor
at 1.00 % in dipropylene glycol. nutty cocoa roasted chocolate peanut green
Odor Type
nutty
biological source
synthetic
Water Solubility 
Fully miscible in water.
JECFA Number
761
BRN 
105778
InChIKey
CAWHJQAVHZEVTJ-UHFFFAOYSA-N
LogP
0.18
CAS DataBase Reference
109-08-0(CAS DataBase Reference)
NIST Chemistry Reference
Pyrazine, methyl-(109-08-0)
EPA Substance Registry System
Pyrazine, methyl- (109-08-0)
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Safety

Hazard Codes 
Xn,Xi,F
Risk Statements 
10-22-36/37/38
Safety Statements 
26-36-16
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
RTECS 
UQ3675000
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29339990
Toxicity
mouse,LD50,intraperitoneal,1820mg/kg (1820mg/kg),Toxicology and Applied Pharmacology. Vol. 17, Pg. 244, 1970.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W330906
Product name
2-Methylpyrazine
Purity
≥99%, FCC, FG
Packaging
100g
Price
$87.4
Updated
2024/03/01
Sigma-Aldrich
Product number
W330906
Product name
2-Methylpyrazine
Purity
≥99%, FCC, FG
Packaging
1kg
Price
$175
Updated
2024/03/01
Sigma-Aldrich
Product number
W330906
Product name
2-Methylpyrazine
Purity
≥99%, FCC, FG
Packaging
5kg
Price
$627
Updated
2024/03/01
Sigma-Aldrich
Product number
M75608
Product name
2-Methylpyrazine
Purity
≥99%
Packaging
25g
Price
$32.5
Updated
2024/03/01
Sigma-Aldrich
Product number
M75608
Product name
2-Methylpyrazine
Purity
≥99%
Packaging
100g
Price
$56.2
Updated
2024/03/01
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2-Methylpyrazine Chemical Properties,Usage,Production

Description

2-Methylpyrazine has an odor threshold in water variously reported at 60,000 or 105,000 ppb. May be prepared from the corresponding carboxylic acid; by catalytic dehydrogenation of 2-methyl-piperazine; by condensation of methylglyoxal with ethylenediamine.

Chemical Properties

2-Methylpyrazine has a nutty, cocoa, green, roasted, chocolate, meaty odor.

Chemical Properties

clear colorless to slightly yellow liquid

Occurrence

Reported found in bakery products, roasted barley, cocoa products, coffee, dairy products, cooked meats, peanuts, filberts, pecans, popcorn, potato chips, rum and whiskey, soy product, roasted filberts, roasted almonds, guava, papaya, asparagus, kohlrabi, baked and fried potato, milk, boiled egg, smoked fish, beer, coffee, sesame seed, rice, sukiyaki, buckwheat, sweet corn, corn tortillas, malt, wort, wild rice, okra, crayfish, clam, squid and maté.

Uses

2-Methylpyrazine is used as flavoring agents in bread fresh bread, butter, chocolate, chocolate cocoa, coffee, meat roasted, nut almond.

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Definition

ChEBI: Methylpyrazine is a member of the class of pyrazines that is pyrazine in which one of the hydrogens is replaced by a methyl group. It is a flavouring agent found in coffee, peanuts and red peppers. It has a role as a flavouring agent, a plant metabolite and a Maillard reaction product.

Preparation

From corresponding carboxylic acid; by catalytic dehydrogenation of 2-methyl-piperazine; by condensation of methylglyoxal with ethylenediamine

Aroma threshold values

Detection: 60 ppb to 100 ppm

Taste threshold values

Taste characteristics at 75 ppm: nutty, brown, musty, roasted and astringent

General Description

2-Methylpyrazine is an alkyl-substituted pyrazine used as a key intermediate in the synthesis of pyrazineamide, an anti-tubercular drug.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Mutation data reported. Flammable liquid when exposed to heat, sparks, or flame. Can react with oxidizing materials. To fight fire, use water spray, foam, dry chemical, CO2. When heated to decomposition it emits highly toxic fumes of NOx.

Purification Methods

Purify it via the picrate and distil the free base. The picrate has m133-134o(from EtOH). [Wiggins & Wise J Chem Soc 4780 1956, Beilstein 23 III/IV 911, 23/5 V 386.]

2-Methylpyrazine Preparation Products And Raw materials

Raw materials

Methylglyoxal Ethylenediamine 2-Methylpiperazine

Preparation Products

Tetramethylpyrazine 5-Methyl-2-pyrazinecarboxylic acid
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2-Methylpyrazine Suppliers

Americas 1 Belgium 1 China 354 Europe 2 France 2 Germany 8 India 22 Japan 6 Norway 1 Singapore 1 Slovakia 1 South Korea 1 Spain 3 Switzerland 2 United Kingdom 15 United States 68 USA 1 Global 489
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View Lastest Price from 2-Methylpyrazine manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2-Methylpyrazine 109-08-0
Price
US $75.00-25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-27
Hebei Weibang Biotechnology Co., Ltd
Product
2-Methylpyrazine 109-08-0
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-19
Shandong Deshang Chemical Co., Ltd.
Product
2-Methylpyrazine 109-08-0
Price
US $8.80-4.50/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 tons
Release date
2024-07-08

109-08-0, 2-MethylpyrazineRelated Search:

Pyrazine Thiophanate-methyl Sulfachoropyrazine sodium 2-Pyrazinecarboxylic acid Pyrazinamide Tribenuron methyl Methyl acetate Kresoxim-methyl Methyl salicylate METSULFURON METHYL Pirimiphos-methyl Methyl 2-Methoxy-3-isobutyl pyrazine 2-Methoxy-3-sec-butyl pyrazine Parathion-methyl 2,3-Pyrazinedicarboxylic acid Tetramethylpyrazine 2-METHOXY-3-METHYLPYRAZINE 98+%,2 OR 5 OR 6-METHOXY-3-METHYLPYRAZINE

  • 2-METHYL-1,4-DIAZINE
  • 2-methyl-1,4-diazinen
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  • 2-Methylpyrazine, 10 mM in DMSO
  • 109-08-0
  • -NCCH3CHNCHCH
  • Mono- & Polyalkylpyrazines
  • Pyrazines
  • Heterocyclic Building Blocks
  • Building Blocks
  • Pyrazine compounds
  • Building Blocks
  • Heterocyclic Building Blocks
  • Alphabetical Listings
  • Flavors and Fragrances
  • M-N
  • Mono- & Polyalkylpyrazines
  • pyrazine Flavor
  • Pyrazine
  • Pyrazines