3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione

Product Name: 3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione
CAS No.: 113418-56-7
Chemical Name: 3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione
Synonyms: Wy-49051;Wy 49051, 10 mM in DMSO;7-[3-[4-(Diphenylmethoxy)-1-piperidinyl]propyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione;3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione;1H-Purine-2,6-dione, 7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-3,7-dihydro-1,3-dimethyl-
CBNumber: CB02425188
Molecular Formula: C28H33N5O3
Formula Weight: 487.59
MOL File: 113418-56-7.mol

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3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione Property

Boiling point:: 672.7±65.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 8.32±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione Chemical Properties,Usage,Production

Uses

Wy 49051 is a potent, orally active H1 receptor antagonist, with IC50 of 44 nM.

in vivo

Wy 49051 shows potent activity against histamine-induced lethality in the guinea pig, with ED₅₀ of 1.91 mg/kg by po, 0.70 mg/kg by ip, and 0.01 mg/kg by iv. The duration of action of 24 is also favorable since there is no decrease in oral efficacy up to 18 h posttreatment^[1].

References

[1] Abou-Gharbia M, et al. New antihistamines: substituted piperazine and piperidine derivatives as novel H1-antagonists. J Med Chem. 1995 Sep 29;38(20):4026-32. DOI:10.1021/jm00020a018

3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione Suppliers

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113418-56-7, 3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dioneRelated Search:

DESVENLAFAXINE SUCCINATE 3H-Imidazo[4,5-c]pyridine, 2-[[(3-methoxyphenyl)methyl]sulfinyl]- N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea 4-[(4-chloroanilino)methyl]-N,N-diethylaniline WYC-210 2(1H)-Quinoxalinone, 3,4-dihydro-7-methoxy-4-(2-methyl-4-quinazolinyl)- Quinoxaline, 3-Methyl-2-[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]-5-(trifluoroMethyl)-

3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione

Wy-49051

1H-Purine-2,6-dione, 7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-3,7-dihydro-1,3-dimethyl-

Wy 49051, 10 mM in DMSO

7-[3-[4-(Diphenylmethoxy)-1-piperidinyl]propyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione

113418-56-7