ChemicalBook > CAS DataBase List > 2-O-Benzylglycolic acid ethyl ester

2-O-Benzylglycolic acid ethyl ester

Product Name: 2-O-Benzylglycolic acid ethyl ester
CAS No.: 32122-09-1
Chemical Name: 2-O-Benzylglycolic acid ethyl ester
Synonyms: 113230;NSC 153412;Benzyloxy ethyl acetate;ethyl 2-phenylmethoxyacetate;2-Benzyloxyacetic acid ethyl ester;(Benzyloxy)acetic acid ethyl ester;2-O-Benzylglycolic acid ethyl ester;2-(Phenylmethoxy)acetic acid ethyl ester;Acetic acid,2-(phenylMethoxy)-, ethyl ester
CBNumber: CB02434856
Molecular Formula: C11H14O3
Formula Weight: 194.23
MOL File: 32122-09-1.mol

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2-O-Benzylglycolic acid ethyl ester Property

Boiling point:: 285℃
Density: 1.069
refractive index: n20/D1.493
Flash point:: 99℃
storage temp.: 2-8°C
form: clear liquid
color: Colorless to Light yellow
InChI: InChI=1S/C11H14O3/c1-2-14-11(12)9-13-8-10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3
InChIKey: PHSWWKXTGAJPCQ-UHFFFAOYSA-N
SMILES: C(OCC)(=O)COCC1=CC=CC=C1
CAS DataBase Reference: 32122-09-1

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Safety

Risk Statements: 52
WGK Germany: 3
HS Code: 2918.99.4700

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 773018
Product name: Ethyl 2-(benzyloxy)acetate
Purity: 97%
Packaging: 1g
Price: $121
Updated: 2023/06/20

TCI Chemical

Product number: E1225
Product name: Ethyl (Benzyloxy)acetate
Purity: >98.0%(GC)
Packaging: 1g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: E1225
Product name: Ethyl (Benzyloxy)acetate
Purity: >98.0%(GC)
Packaging: 5g
Price: $79
Updated: 2025/07/31

TRC

Product number: E900083
Product name: Ethyl 2-(benzyloxy)acetate
Packaging: 500mg
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: 3549AB
Product name: Ethyl 2-(benzyloxy)acetate
Packaging: 1g
Price: $84
Updated: 2021/12/16

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2-O-Benzylglycolic acid ethyl ester Chemical Properties,Usage,Production

Synthesis

105-36-2

100-51-6

32122-09-1

The general procedure for the synthesis of ethyl 2-benzyloxyacetate from ethyl bromoacetate and benzyl alcohol was as follows: 47 ml (0.454 mol) of benzyl alcohol was added dropwise over a period of 30 minutes to a mixture of 21.8 g (0.545 mol) of 60% sodium hydride (NaH) suspended in 1000 ml of anhydrous toluene. The mixture was stirred at room temperature for 4 hours. Subsequently, the suspension was cooled in a water-ice bath and 66 ml (0.595 mol) of ethyl bromoacetate was added dropwise over 45 min. The reaction mixture was heated to room temperature and stirring was continued for 1 hour. The entire mixture was poured into ice water (1200 ml) acidified with 10 ml of concentrated hydrochloric acid. The organic and aqueous phases were separated and the aqueous phase was extracted three times (3x) with ether. The combined organic phase was washed with brine and dried with anhydrous magnesium sulfate. After filtration to remove the desiccant, the organic solvent was removed by evaporation under reduced pressure. The residue was purified by reduced pressure distillation. Ultimately, 66.7 g (76% yield) of ethyl 2-benzyloxyacetate was obtained as a colorless liquid (boiling point Tb = 104-106 °C/ 0.7 torr). The product was characterized by 1H NMR (500 MHz, CDCl3) and mass spectrometry (MS-ESI): 1H NMR δ: 7.39-7.28 (m, 5H), 4.63 (s, 2H), 4.23 (q, J = 7.1 Hz, 2H), 4.09 (s, 2H), 1.28 (t, J = 7.1 Hz, 3H).MS-ESI: ( m/z) calculated value for C11H14O3 [M + H]+: 195.23; measured value: 195.1.

References

[1] Patent: WO2014/16789, 2014, A1. Location in patent: Page/Page column 29
[2] Patent: US5942515, 1999, A
[3] Patent: WO2016/157091, 2016, A1. Location in patent: Page/Page column 20-21
[4] Tetrahedron, 2009, vol. 65, # 34, p. 6925 - 6931
[5] European Journal of Medicinal Chemistry, 2017, vol. 138, p. 630 - 643

2-O-Benzylglycolic acid ethyl ester Preparation Products And Raw materials

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View Lastest Price from 2-O-Benzylglycolic acid ethyl ester manufacturers

Career Henan Chemical Co

Product: 2-O-Benzylglycolic acid ethyl ester 32122-09-1
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-04

32122-09-1, 2-O-Benzylglycolic acid ethyl esterRelated Search:

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NSC 153412

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32122-09-1