ChemicalBook > CAS DataBase List > 1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE

1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE

Product Name
1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE
CAS No.
154130-99-1
Chemical Name
1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE
Synonyms
PD 144418;PD 144418 OXALATE;Pyridine,1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propyl-;1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE
CBNumber
CB02446510
Molecular Formula
C18H22N2O
Formula Weight
282.38
MOL File
154130-99-1.mol
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1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE Property

Boiling point:
453.2±45.0 °C(Predicted)
Density 
1.067±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at RT
solubility 
<18.62mg/ml in DMSO
form 
solid
pka
8.10±0.40(Predicted)
color 
Off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2606
Product name
PD144418oxalate
Purity
≥98%(HPLC)
Packaging
50
Price
$794
Updated
2021/12/16
Tocris
Product number
2606
Product name
PD144418oxalate
Purity
≥98%(HPLC)
Packaging
10
Price
$193
Updated
2021/12/16
ApexBio Technology
Product number
B7125
Product name
PD144418oxalate
Packaging
10mg
Price
$290
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010247
Product name
1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE
Purity
95.00%
Packaging
10MG
Price
$329.7
Updated
2021/12/16
ApexBio Technology
Product number
B7125
Product name
PD144418oxalate
Packaging
50mg
Price
$1221
Updated
2021/12/16
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1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE Chemical Properties,Usage,Production

Uses

PD 144418 is high affinity, selective σ1 ligand (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively). PD 144418 displays no significant activity at a wide range of other receptors, ion channels and enzymes. PD 144418 antagonizes mescaline-induced scratching in mice following i.p. administration.

Biological Activity

High affinity, selective σ 1 ligand (K i values are 0.08 and 1377 nM for σ 1 and σ 2 respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration.

in vivo

PD 144418 (10 mg/kg; intraperitoneal injection; male CD-1 mice) treatment antagonizes Mescaline-induced scratching at doses that did not alter spontaneous motor activity, with PD 144418 showing ED50 values of 7.0 mg/kg i.p.[1].

Animal Model:Male CD-1 mice induced with Mescaline[1]
Dosage:10 mg/kg
Administration:Intraperitoneal injection
Result:Antagonized mescaline-induced scratching at doses that did not alter spontaneous motor activity.

1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE Suppliers

Canada 1 China 26 India 1 United Kingdom 1 United States 5 USA 1 Global 35
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View Lastest Price from 1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE manufacturers

Career Henan Chemical Co
Product
1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE 154130-99-1
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2018-08-20

154130-99-1, 1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATERelated Search:

1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE Isoxazole, 3-(4-methylphenyl)- (9CI)

  • PD 144418 OXALATE
  • 1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE
  • PD 144418
  • Pyridine,1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propyl-
  • 154130-99-1
  • C18H22N2OC2H2O4
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