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1-Chloro-1H-pyrrolo[1,2-a]pyrazine

Product Name
1-Chloro-1H-pyrrolo[1,2-a]pyrazine
CAS No.
136927-64-5
Chemical Name
1-Chloro-1H-pyrrolo[1,2-a]pyrazine
Synonyms
1-Chloro-1H-pyrrolo[1,2-a...;1-Chloropyrrolo[1,2-a]pyrazine;1-CHLOROH-PYRROLO[1,2-A]PYRAZINE;Pyrrolo[1,2-a]pyrazine, 1-chloro-;1-Chloro-1H-pyrrolo[1,2-a]pyrazine;1-Chloro-1H-pyrrolo[1,2-a]pyrazine
CBNumber
CB02451417
Molecular Formula
C7H5ClN2
Formula Weight
152.58
MOL File
136927-64-5.mol
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1-Chloro-1H-pyrrolo[1,2-a]pyrazine Property

Density 
1.35
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
-1.25±0.30(Predicted)
Appearance
Off-white to yellow Solid
CAS DataBase Reference
136927-64-5
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Safety

Risk Statements 
43
Safety Statements 
36/37
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SYX00428
Product name
1-Chloro-1H-pyrrolo[1,2-a]pyrazine
Packaging
1g
Price
$924
Updated
2025/07/31
TRC
Product number
B405498
Product name
1-chloropyrrolo[1,2-a]pyrazine
Packaging
100mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC162569
Product name
1-Chloropyrrolo[1,2-a]pyrazine
Packaging
50mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC162569
Product name
1-Chloropyrrolo[1,2-a]pyrazine
Packaging
100mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC162569
Product name
1-Chloropyrrolo[1,2-a]pyrazine
Packaging
250mg
Price
$200
Updated
2021/12/16
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1-Chloro-1H-pyrrolo[1,2-a]pyrazine Chemical Properties,Usage,Production

Uses

1-Chloro-1H-pyrrolo[1,2-a]pyrazine is a pharmaceutical intermediate compound widely used in the pharmaceutical industry and laboratory research.

Synthesis

136927-63-4

136927-64-5

The general procedure for the synthesis of 1-chloropyrrolo[1,2-a]pyrazine from pyrrolo[1,2-a]pyrazin-1(2H)-one was as follows: pyrrolo[1,2-a]pyrazin-1(2H)-one (2.14 g, 16.0 mmol) was dissolved in phosphorus trichloride (20 mL), and the reaction was stirred for 16 h at room temperature. Upon completion of the reaction, the reaction mixture was quenched by slowly pouring it into ice water and neutralized with sodium bicarbonate solution. Subsequently, the aqueous phase was extracted several times with dichloromethane, and the combined organic phases were washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting residue was purified by silica gel column chromatography with 10% ethyl acetate/hexane as eluent to afford 1-chloropyrrolo[1,2-a]pyrazine (1.1 g, 45% yield). The structure of the product was analyzed by 1H NMR (500 MHz, CDCl3, δ: 7.62 (d, J = 4.5 Hz, 1H), 7.34 (dd, J = 2.5, 1.5 Hz, 1H), 7.12 (d, J = 4.5 Hz, 1H), 6.74-6.71 (m, 2H)), 13C NMR (125 MHz, CDCl3, δ. 154.4, 126.0, 125.6, 118.3, 117.4, 115.6, 105.2) and mass spectrometry (LRMS (ES): calculated value of C7H6ClN2 [M+1]+ 153, measured value of 153.2) confirmed.

References

[1] Journal of the American Chemical Society, 2006, vol. 128, # 48, p. 15372 - 15373
[2] Patent: WO2007/38387, 2007, A2. Location in patent: Page/Page column 80

1-Chloro-1H-pyrrolo[1,2-a]pyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Chloro-1H-pyrrolo[1,2-a]pyrazine Suppliers

China 61 India 1 Switzerland 1 United Kingdom 2 United States 8 Global 73
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
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001-617-206-9595
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sales@chemreagents.com
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United States
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Alchem Pharmtech,Inc.
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8485655694
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sales@alchempharmtech.com
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United States
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Synthonix Inc
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United States
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Combi-Blocks Inc.
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SynQuest Laboratories, Inc.
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Riedel-de Haen AG
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Matrix Scientific
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sales@matrixscientific.com
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Proactive Molecular Research
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tony@proactivemr.com
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United States
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View Lastest Price from 1-Chloro-1H-pyrrolo[1,2-a]pyrazine manufacturers

Career Henan Chemica Co
Product
1-CHLOROH-PYRROLO[1,2-A]PYRAZINE 136927-64-5
Price
US $17.00/g
Min. Order
25g
Purity
95%
Supply Ability
1KG
Release date
2020-10-27

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