ETHYL 2-AMINO-1H-PYRROLE-3-CARBOXYLATE
- Product Name
- ETHYL 2-AMINO-1H-PYRROLE-3-CARBOXYLATE
- CAS No.
- 108290-86-4
- Chemical Name
- ETHYL 2-AMINO-1H-PYRROLE-3-CARBOXYLATE
- Synonyms
- SKL228;ETHYL 2-AMINO-1H-PYRROLE-...;Ethyl 2-Aminopyrrole-3-carboxylate;Ethyl 2-amino-1H-pyrrol-3-carboxylate;ETHYL 2-AMINO-1H-PYRROLE-3-CARBOXYLATE;2-amino-1H-Pyrrole-3-carboxy-lic acid ethyl ester;1H-Pyrrole-3-carboxylicacid, 2-aMino-, ethyl ester;2-amino-1H-Pyrrole-3-carboxylic acid ethyl ester (9CI ACI);1H-Pyrrole-3-carboxylic acid, 2-amino-, ethyl ester (9CI, ACI)
- CBNumber
- CB02453239
- Molecular Formula
- C7H10N2O2
- Formula Weight
- 154.17
- MOL File
- 108290-86-4.mol
ETHYL 2-AMINO-1H-PYRROLE-3-CARBOXYLATE Property
- Boiling point:
- 360.5±22.0 °C(Predicted)
- Density
- 1.238±0.06 g/cm3(Predicted)
- storage temp.
- -20°C, protect from light
- pka
- 18.24±0.50(Predicted)
- Appearance
- Light green to green Solid
- InChI
- InChI=1S/C7H10N2O2/c1-2-11-7(10)5-3-4-9-6(5)8/h3-4,9H,2,8H2,1H3
- InChIKey
- XKJUSNOUOLSNJN-UHFFFAOYSA-N
- SMILES
- N1C=CC(C(OCC)=O)=C1N
- CAS DataBase Reference
- 108290-86-4
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A629275
- Product name
- 2-Amino-1H-pyrrole-3-carboxylicAcidEthylEster
- Packaging
- 500mg
- Price
- $440
- Updated
- 2021/12/16
- Product number
- 4H56-1-KP
- Product name
- Ethyl 2-amino-1H-pyrrole-3-carboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- AS13337
- Product name
- 2-Amino-1H-pyrrole-3-carboxylicacidethylester
- Purity
- 97+%
- Packaging
- 1g
- Price
- $218
- Updated
- 2021/12/16
- Product number
- 4H56-1-KP
- Product name
- Ethyl 2-amino-1H-pyrrole-3-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $625
- Updated
- 2021/12/16
- Product number
- X6512
- Product name
- 2-Amino-1H-pyrrole-3-carboxylicacidethylester
- Packaging
- 5g
- Price
- $667
- Updated
- 2021/12/16
ETHYL 2-AMINO-1H-PYRROLE-3-CARBOXYLATE Chemical Properties,Usage,Production
Uses
2-Amino-1H-Pyrrole-3-carboxylic acid ethyl ester acts as a reagent in the synthesis of pyrrolo pyrimidines which functions as glucocerebrosidase activators use in treatment of medical disorders.
Synthesis
107-20-0
50551-10-5
108290-86-4
1. Preparation of ethyl 2-amino-1H-pyrrole-3-carboxylate. Ethyl 3-amino-3-iminopropionate (390 mg, 3.0 mmol) was dissolved in ethyl acetate (20 mL) under argon protection with vigorous stirring. Anhydrous chloroacetaldehyde was added rapidly at 22 °C. The reaction mixture was stirred for 10 minutes and then heated to reflux for 20 minutes. Cool to room temperature and filter through a silica gel column (15 g). The residue in the reaction flask was washed several times with ethyl acetate (20 mL x 5) and the filtrates were combined. The filtrate was concentrated under reduced pressure to give 120 mg of light yellow solid product in 47% yield. The product was characterized as follows: 1H NMR (500 MHz, CDCl3) δ (ppm): 7.92 (br, 1H), 6.28 (t, J = 2.8 Hz, 1H), 6.15 (dd, J = 2.0 Hz, 1H), 4.94 (br, 2H), 4.24 (q, J = 7.1 Hz, 2H), 1.33 (t, J = 7.1 Hz, 3H).13C NMR (125 MHz, CDCl3) δ (ppm): 166.5, 145.4, 110.3, 107.5, 94.5, 59.3, 14.7.
References
[1] Journal of Heterocyclic Chemistry, 1986, vol. 23, # 5, p. 1555 - 1560
[2] Patent: WO2017/4408, 2017, A1. Location in patent: Paragraph 0087; 0089; 0090
[3] Patent: WO2016/73891, 2016, A1. Location in patent: Paragraph 00204
[4] Patent: US9447100, 2016, B2. Location in patent: Page/Page column 556; 557
ETHYL 2-AMINO-1H-PYRROLE-3-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL 2-AMINO-1H-PYRROLE-3-CARBOXYLATE manufacturers
- Product
- ETHYL 2-AMINO-1H-PYRROLE-3-CARBOXYLATE 108290-86-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-05
- Product
- ETHYL 2-AMINO-1H-PYRROLE-3-CARBOXYLATE 108290-86-4
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-13