BENZYL (2-OXO-2-PHENYLETHYL)CARBAMATE

Product Name: BENZYL (2-OXO-2-PHENYLETHYL)CARBAMATE
CAS No.: 146553-06-2
Chemical Name: BENZYL (2-OXO-2-PHENYLETHYL)CARBAMATE
Synonyms: Duvelisib Impurity 1;Metaraminol Impurity 43;D-Alanine-N'-Methoxy-N'-Methylamide;BENZYL (2-OXO-2-PHENYLETHYL)CARBAMATE;N-Boc-D-alanine N'-Methoxy-N'-MethylaMide;(tert-butoxycarbonyl)-N-methoxy-N-methyl-D-alaninamide;(R)-tert-butyl 1-(Methoxy(Methyl)aMino)-1-oxopropan-2-ylcarbaMat;(R)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate;tert-butyl (R)-(1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate;(R)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate - [B91279]
CBNumber: CB02454665
Molecular Formula: C10H20N2O4
Formula Weight: 232.28
MOL File: 146553-06-2.mol

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BENZYL (2-OXO-2-PHENYLETHYL)CARBAMATE Property

Density: 1.070±0.06 g/cm3(Predicted)
storage temp.: Store at Room Tem.
pka: 11.19±0.46(Predicted)

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 057765
Product name: (R)-tert-Butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate
Purity: 95%
Packaging: 1g
Price: $53
Updated: 2021/12/16

Matrix Scientific

Product number: 057765
Product name: (R)-tert-Butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate
Purity: 95%
Packaging: 5g
Price: $187
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0004942
Product name: D-ALANINE-N'-METHOXY-N'-METHYLAMIDE
Purity: 95.00%
Packaging: 5G
Price: $371.7
Updated: 2021/12/16

Matrix Scientific

Product number: 057765
Product name: (R)-tert-Butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate
Purity: 95%
Packaging: 25g
Price: $667
Updated: 2021/12/16

AK Scientific

Product number: 4464AD
Product name: (R)-tert-Butyl1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate
Packaging: 25g
Price: $950
Updated: 2021/12/16

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BENZYL (2-OXO-2-PHENYLETHYL)CARBAMATE Chemical Properties,Usage,Production

Synthesis

15761-38-3

6638-79-5

146553-06-2

To an oven-dried 100 mL round-bottomed flask were added N-tert-butoxycarbonyl-L-alanine (3.0 g, 15.8 mmol), anhydrous CH2Cl2 (60 mL), and N,N-diisopropylethylamine (DIPEA, 2.5 mL, 14.2 mmol), and the resulting solution was cooled to 0 °C. 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC, 3.7 g, 19.0 mmol) and 1-hydroxybenzotriazole (HOBt, 2.6 g, 19.0 mmol) were added in batches over a period of 10 min at 0 °C. The mixture was stirred at 0 °C for 10 min, then N,O-dimethylhydroxylamine hydrochloride (1.9 g, 19.0 mmol) and DIPEA (3.3 mL, 19.0 mmol) were added. The mixture was continued to be stirred at 0 °C for 1 h, followed by warming up to 25 °C and kept for 16 h. The reaction was carried out at 0 °C. Upon completion of the reaction, the reaction mixture was diluted with CH2Cl2 (300 mL) and the organic layer was washed sequentially with 2N HCl (3 × 180 mL), saturated NaHCO3 solution (2 × 180 mL) and brine (2 × 180 mL). The organic phase was dried over anhydrous Na2SO4 and concentrated under reduced pressure to give a white solid amide product (3.6 g, 99% yield), which did not require further purification. Product characterization data: mp(CHCl3) 138-140 °C; 1H NMR (300 MHz, DMSO) δ 1.11 (d, J = 6.9 Hz, 3H), 1.33 (s, 9H), 3.07 (s, 3H), 3.69 (s, 3H), 4.36 (t, J = 6.9 Hz, 1H), 7.03 (d, J = 6.9 Hz, 1H); ESI MS: 4.36 (t, J = 6.9 Hz, 1H), 7.03 (d, J = 6.9 Hz, 1H). 1H); ESI MS: m/z 255 (M + Na)+. The above amide product (3.7 g, 15.8 mmol) was dissolved in anhydrous THF (100 mL) and cooled to 0°C. Lithium aluminum hydride (LiAlH4, 660 mg, 17.4 mmol) was added to this solution and the reaction was stirred for 20 min. After the completion of the reaction was monitored by TLC, the reaction was quenched with 5% HCl solution. The organic layer was evaporated and the aqueous phase was extracted with EtOAc (3 x 30 mL). The organic phases were combined, dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford tert-butyl (R)-1-(methoxy(methyl)amino)-1-oxo-2-propylcarbamate as a white solid (2.6 g, 94% yield), which did not require further purification. Product characterization data: mp(CHCl3) 82-84 °C; 1H NMR (300 MHz, DMSO) δ 1.09 (d, J = 7.5 Hz, 3H), 1.36 (s, 9H), 3.83 (t, J = 9.9 Hz, 1H), 7.33 (d, J = 5.7 Hz, 1H), 9.39 (s, 1H); ESI MS: m/z 173 (M + H)+, 196 (M + Na)+.

References

[1] Angewandte Chemie - International Edition, 2013, vol. 52, # 34, p. 8957 - 8960
[2] Angew. Chem., 2013, vol. 125, # 34, p. 9126 - 9129,4
[3] Journal of Labelled Compounds and Radiopharmaceuticals, 2014, vol. 57, # 4, p. 275 - 278
[4] Organic Letters, 2002, vol. 4, # 16, p. 2665 - 2668
[5] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 15, p. 3582 - 3586

BENZYL (2-OXO-2-PHENYLETHYL)CARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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BENZYL (2-OXO-2-PHENYLETHYL)CARBAMATE Suppliers

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View Lastest Price from BENZYL (2-OXO-2-PHENYLETHYL)CARBAMATE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: BENZYL (2-OXO-2-PHENYLETHYL)CARBAMATE 146553-06-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-07-08

146553-06-2, BENZYL (2-OXO-2-PHENYLETHYL)CARBAMATERelated Search:

4-METHOXYBENZYL N-(3-CHLORO-1,4-DIOXO-1,4-DIHYDRO-2-NAPHTHALENYL)CARBAMATE 4-NITROBENZYL N-(3-CHLORO-1,4-DIOXO-1,4-DIHYDRO-2-NAPHTHALENYL)CARBAMATE 3,4-DIMETHOXYBENZYL N-(3-CHLORO-1,4-DIOXO-1,4-DIHYDRO-2-NAPHTHALENYL)CARBAMATE 2-CHLOROBENZYL N-(3-CHLORO-1,4-DIOXO-1,4-DIHYDRO-2-NAPHTHALENYL)CARBAMATE

(tert-butoxycarbonyl)-N-methoxy-N-methyl-D-alaninamide

(R)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate

(R)-tert-butyl 1-(Methoxy(Methyl)aMino)-1-oxopropan-2-ylcarbaMat

CarbaMic acid, N-[(1R)-2-(MethoxyMethylaMino)-1-Methyl-2-oxoethyl]-, 1,1-diMethylethyl ester

N-Boc-D-alanine N'-Methoxy-N'-MethylaMide

Carbamic acid, [2-(methoxymethylamino)-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester, (R)-

BENZYL (2-OXO-2-PHENYLETHYL)CARBAMATE

D-Alanine-N'-Methoxy-N'-Methylamide

Metaraminol Impurity 43

Duvelisib Impurity 1

(R)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate - [B91279]

tert-butyl (R)-(1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate

146553-06-2