CAY10397
- Product Name
- CAY10397
- CAS No.
- 78028-01-0
- Chemical Name
- CAY10397
- Synonyms
- CK47A;CAY10397;Ph CK 47A;CAY-10397,CAY10397;DPHOCQNZARWEHS-UHFFFAOYSA-N;5-[[4-(ETHOXYCARBONYL)PHENYL]AZO]-2-HYDROXY-BENZENEACETIC ACID;5-[2-[4-(Ethoxycarbonyl)phenyl]diazenyl]-2-hydroxybenzeneacetic acid;5-[[4-(Ethoxycarbonyl)phenyl]azo]-2-hydroxybenzeneacetic acid, CK47A;Benzeneacetic acid, 5-[2-[4-(ethoxycarbonyl)phenyl]diazenyl]-2-hydroxy-
- CBNumber
- CB0245681
- Molecular Formula
- C17H16N2O5
- Formula Weight
- 328.32
- MOL File
- 78028-01-0.mol
CAY10397 Property
- Boiling point:
- 578.0±50.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- 0.1 M Na2CO3: 200 μg/ml; DMF: 35 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml
- form
- solid
- pka
- 4.05±0.10(Predicted)
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- C6734
- Product name
- CAY10397
- Purity
- >98%, solid
- Packaging
- 1mg
- Price
- $175
- Updated
- 2025/07/31
- Product number
- 70130
- Product name
- CAY10397
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $59
- Updated
- 2024/03/01
- Product number
- 70130
- Product name
- CAY10397
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $253
- Updated
- 2024/03/01
- Product number
- 70130
- Product name
- CAY10397
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $448
- Updated
- 2024/03/01
- Product number
- 70130
- Product name
- CAY10397
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $979
- Updated
- 2024/03/01
CAY10397 Chemical Properties,Usage,Production
Uses
Prostaglandins are rapidly inactivated in vivo by the action of 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH). This enzyme oxidizes the 15-hydroxyl group and hydrogenates the 13,14-double bond, producing 13,14-dihydro-15 keto metabolites with greatly reduced biological activity. CAY10397 is a selective inhibitor of 15-hydroxy PGDH with an IC50 of approximately 10 μM. CAY10397 acts to prolong the lifetime and activity of endogenously produced prostaglandins both in cell culture and in vivo.[Cayman Chemical]
Definition
ChEBI: CAY10397 is a member of the class of azobenzenes that is azobenzene in which one of the phenyl groups is substituted at position 4 by an ethoxycarbonyl group, while the other is substituted by a carboxymethyl group at position 3 and a hydroxy group at position 4. It is a potent and selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-hydroxy-PGDH). It has a role as an EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor. It is a dicarboxylic acid monoester, an ethyl ester, a member of azobenzenes and a member of phenols.
Biological Activity
Potent and selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-hydroxy-PGDH). Acts to prolong the lifetime and activity of endogenously produced prostaglandins both in vitro and in vivo.
CAY10397 Preparation Products And Raw materials
Raw materials
Preparation Products
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