(4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID PINACOL ESTER

Product Name: (4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID PINACOL ESTER
CAS No.: 454185-98-9
Chemical Name: (4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID PINACOL ESTER
Synonyms: methyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-;(4-Methoxycarbonylmethylphenyl)boronic acid picol ester;(4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID PINACOL ESTER;Methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);[4-(Methoxycarbonyl)methyl]benzeneboronicacidpinacolester;(4-Methoxycarbonylmethyl)Phenylboronic Acid Pinacol Ester,>98%;methyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate;Methyl [4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate;(4-Methoxycarbonylmethylphenyl) boronic acid pinacol ester - [M12474];Methyl 2-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate
CBNumber: CB02457686
Molecular Formula: C15H21BO4
Formula Weight: 276.14
MOL File: 454185-98-9.mol

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(4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID PINACOL ESTER Property

Melting point:: 41-45 °C
Boiling point:: 363.0±25.0 °C(Predicted)
Density: 1.07±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Methanol
form: powder to crystal
color: White to Orange to Green
CAS DataBase Reference: 454185-98-9

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Safety

HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3236
Product name: Methyl 2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate
Packaging: 1G
Price: $62
Updated: 2025/07/31

TCI Chemical

Product number: M3236
Product name: Methyl 2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate
Packaging: 5G
Price: $219
Updated: 2025/07/31

TRC

Product number: M329250
Product name: (4-Methoxycarbonylmethyl)phenylboronicacidpinacolester
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Synthonix

Product number: M12474
Product name: (4-Methoxycarbonylmethylphenyl)boronicacidpinacolester
Purity: 95+%
Packaging: 1g
Price: $40
Updated: 2021/12/16

Chem-Impex

Product number: 39941
Product name: Methyl2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 1G
Price: $81.54
Updated: 2021/12/16

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(4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID PINACOL ESTER Chemical Properties,Usage,Production

Uses

(4-Methoxycarbonylmethyl)phenylboronic acid pinacol ester

Synthesis

41841-16-1

73183-34-3

454185-98-9

To a 200 mL round-bottomed flask equipped with a magnetic stirrer was sequentially added [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (0.799 g, 1.09 mmol), 4,4,4',4',5,5,5',5'-octamethyl-2,2'-bis(1,3,2-dioxaborolane) (bis(boronic acid pinacol ester), 6.65 g 26.2 mmol) and potassium acetate (4.28 g, 43.7 mmol). 1,4-dioxane (100 mL) was added to dissolve the above solid mixture. The flask was sealed, evacuated and displaced three times with nitrogen to exclude oxygen. Methyl 2-(4-bromophenyl)acetate (5.00 g, 21.8 mmol) was then added. The reaction mixture was heated to 70 °C and kept stirring for 6 hours. After completion of the reaction, it was cooled to room temperature and the reaction solution was poured into saturated brine to separate the organic and aqueous phases. The aqueous phase was extracted with ethyl acetate (3 x 125 mL), the organic phases were combined and dried with anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure. The crude product was purified by fast column chromatography with an eluent gradient of 0-30% ethyl acetate/hexane to afford methyl 4-boronic acid pinacol ester phenylacetate as a colorless, clear liquid (4.93 g, 70% yield). The product was confirmed by NMR hydrogen spectrum (1H NMR, 400 MHz, DMSO-d6): δ 7.68-7.58 (m, 2H), 7.35-7.23 (m, 2H), 3.71 (s, 2H), 3.61 (s, 3H), 1.29 (s, 12H); NMR carbon spectrum (13C NMR, 101 MHz, DMSO-d6) δ 171.29, 137.72, 134.45, 128.86, 83.56, 82.79, 51.68, 40.23, 24.62; mass spectrum (EIMS) m/z 276 ([M]+).

References

[1] Patent: WO2006/46593, 2006, A1. Location in patent: Page/Page column 180-181
[2] Patent: WO2006/109633, 2006, A1. Location in patent: Page/Page column 155-156
[3] Chemical Communications, 2015, vol. 51, # 77, p. 14505 - 14508
[4] Journal of Organic Chemistry, 2006, vol. 71, # 15, p. 5594 - 5598
[5] Angewandte Chemie - International Edition, 2014, vol. 53, # 45, p. 12077 - 12080

(4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID PINACOL ESTER Preparation Products And Raw materials

Raw materials

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View Lastest Price from (4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID PINACOL ESTER manufacturers

Career Henan Chemical Co

Product: (4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID PINACOL ESTER 454185-98-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-25

454185-98-9, (4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID PINACOL ESTERRelated Search:

Dimethyl carbonate 2-(5-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4-Amino-2-fluorophenylboronic acid, pinacol ester 1-Methylindazole-5-boroni... 4-Nitrophenylboronic acid pinacol ester 4-(ethoxycarbonylmethyl)phenylboronic acid, pinaco 3-Fluoro-4-nitrophenylboronic acid,pinacol ester 3-Fluoro-4-methoxyphenylboronic acid, pinacol ester 2,2,2-Trifluoroacetophenone-4-boronic acid pinacol ester 1H-Indazole, 1-Methyl-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 4-(Methoxycarbonyl)-2-methylphenylboronic acid pinacol ester 2-(3,5-Dichloro-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID PINACOL ESTER 4-CARBOXYMETHYL-PHENYLBORONIC ACID (4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID (4-ETHOXYCARBONYLMETHYLPHENYL)BORONIC ACID, PINACOL ESTER 4-(2-Hydroxyethyl)phenylboronicacid Phenylacetic acid-4-boronic acid pinacol ester

Methyl [4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate

Benzeneacetic acid, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester

Methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)

(4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID PINACOL ESTER

methyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate

[4-(Methoxycarbonyl)methyl]benzeneboronicacidpinacolester

Methyl 2-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

methyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-

(4-Methoxycarbonylmethylphenyl)boronic acid picol ester

(4-Methoxycarbonylmethyl)Phenylboronic Acid Pinacol Ester,>98%

2-[(4-MethoxyCarbonylmethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetic Acid Methyl Ester

(4-Methoxycarbonylmethylphenyl) boronic acid pinacol ester - [M12474]

454185-98-9

C15H23BO5