ChemicalBook > CAS DataBase List > 2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL

2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL

Product Name
2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL
CAS No.
760990-08-7
Chemical Name
2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL
Synonyms
3-Fluoro-4-hydroxyphenylboronic acid,pinacol ester;3-Fluoro-4-hydroxybenzeneboronic acid pinacol ester, 96%;2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL;Phenol, 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber
CB02459392
Molecular Formula
C12H16BFO3
Formula Weight
238.06
MOL File
760990-08-7.mol
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2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL Property

Melting point:
99.3-100.2 °C
Boiling point:
324.9±32.0 °C(Predicted)
Density 
1.15±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
8.39±0.35(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
760990-08-7
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Safety

HS Code 
2931900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
F595358
Product name
3-Fluoro-4-hydroxyphenylboronicacid,pinacolester
Packaging
500mg
Price
$150
Updated
2021/12/16
AK Scientific
Product number
X0984
Product name
3-Fluoro-4-hydroxyphenylboronicacidpinacolester
Packaging
10g
Price
$521
Updated
2021/12/16
AK Scientific
Product number
J98428
Product name
3-Fluoro-4-hydroxyphenylboronicacidpinacolester
Packaging
10g
Price
$390
Updated
2021/12/16
AK Scientific
Product number
J98428
Product name
3-Fluoro-4-hydroxyphenylboronicacidpinacolester
Packaging
25g
Price
$780
Updated
2021/12/16
AK Scientific
Product number
X0984
Product name
3-Fluoro-4-hydroxyphenylboronicacidpinacolester
Packaging
1g
Price
$101
Updated
2021/12/16
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2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL Chemical Properties,Usage,Production

Uses

3-Fluoro-4-hydroxyphenylboronic acid, pinacol ester

Synthesis

2105-94-4

73183-34-3

760990-08-7

4-Bromo-2-fluorophenol (1.9 g, 9.9 mmol), bis(pinacolato)diboron (2.9 g, 11.4 mmol), potassium acetate (3.90 g, 39.7 mmol), and DPPF (0.27 g, 0.49 mmol) were used as raw materials and dissolved in 32 mL 1,4-dioxane. Nitrogen was passed into the solution for 5 min to deoxidize. Subsequently, PdCl2(dppf)-DCM (0.4 g, 0.49 mmol) was added and the reaction mixture was stirred under reflux conditions for 4 hours. Upon completion of the reaction, the reaction solution was filtered through diatomaceous earth and purified by column chromatography to afford the target product 3-fluoro-4-hydroxyphenylboronic acid pinacol ester (2.2 g, 93% yield).1H NMR (CDCl3) δ 7.49 (2H, m), 6.98 (1H, t), 5.31 (1H, brs), 1.33 (12H, s).

References

[1] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0417
[2] Patent: US2010/324068, 2010, A1. Location in patent: Page/Page column 30
[3] Patent: WO2014/209034, 2014, A1. Location in patent: Paragraph 432; 433; 434
[4] Patent: CN105384638, 2016, A. Location in patent: Paragraph 0678; 0679; 0680; 0681
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 23, p. 10479 - 10497

2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL Suppliers

Canada 1 China 59 India 3 United States 6 Global 69
R&D Scientific Inc.
Tel
+1-2266000236
Email
sales@rdscientific.com
Country
Canada
ProdList
1914
Advantage
58
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View Lastest Price from 2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL manufacturers

R&D Scientific Inc.
Product
3-Fluoro-4-hydroxybenzeneboronic acid pinacol ester 760990-08-7
Price
US $350.00/g
Min. Order
1g
Purity
97
Supply Ability
50 Kg
Release date
2024-02-12
Career Henan Chemical Co
Product
2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL 760990-08-7
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
1kg; 5kg
Release date
2020-02-03

760990-08-7, 2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOLRelated Search:

2,4,6-TriMethoxyphenylboronic acid, pinacol ester 2-Aminopyridine-5-boronic acid, pinacol ester 4,4,5,5-tetramethyl-2-(4-nitronaphthalen-1-yl)-1,3,2-dioxaborolane 3-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenol 4-(4,4,5,5-TetraMethyl-[1,3,2]dioxaborolan-2-yl)-2-trifluoroMethyl-phenol 2-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenol 3-Chloro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenol 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-1-amine 2-AMINOPYRIDINE-4-BORONIC ACID PINACOL ESTER 3-Chloro-4-hydroxyphenylboronic acid, pinacol ester 3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

  • 2-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL
  • 3-Fluoro-4-hydroxyphenylboronic acid,pinacol ester
  • 3-Fluoro-4-hydroxybenzeneboronic acid pinacol ester, 96%
  • Phenol, 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • 760990-08-7