N-ETHYLLIDOCAINE BROMIDE

Product Name: N-ETHYLLIDOCAINE BROMIDE
CAS No.: 24003-58-5
Chemical Name: N-ETHYLLIDOCAINE BROMIDE
Synonyms: N-ETHYLLIDOCAINE BROMIDE;QX 314 bromide,QX314 bromide;[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium:bromide;2-[(2,6-DIMETHYLPHENYL)AMINO]-N,N,N-TRIETHYL-2-OXO-ETHANAMINIUM BROMIDE
CBNumber: CB02463601
Molecular Formula: C16H27BrN2O
Formula Weight: 343.31
MOL File: 24003-58-5.mol

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N-ETHYLLIDOCAINE BROMIDE Property

Melting point:: 214-215 °C
storage temp.: Desiccate at RT
solubility: insoluble in EtOH; ≥10.5 mg/mL in H2O; ≥25.55 mg/mL in DMSO
form: crystalline solid
color: White
Water Solubility: Soluble to 100 mM in water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10011032
Product name: QX-314 (bromide)
Purity: ≥98%
Packaging: 25mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 10011032
Product name: QX-314 (bromide)
Purity: ≥98%
Packaging: 50mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 10011032
Product name: QX-314 (bromide)
Purity: ≥98%
Packaging: 100mg
Price: $81
Updated: 2024/03/01

TRC

Product number: Q950000
Product name: QX314Bromide
Packaging: 100mg
Price: $75
Updated: 2021/12/16

ApexBio Technology

Product number: B6547
Product name: QX314bromide
Packaging: 100mg
Price: $90
Updated: 2021/12/16

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N-ETHYLLIDOCAINE BROMIDE Chemical Properties,Usage,Production

Uses

QX-314 bromide is a derivative of Lidocaine. It is a local anesthetic.

Biological Activity

qx 314 bromide is a positively charged, membrane-impermeable quaternary lidocaine derivative [1][2][3][4].qx 314 bromide is a local anesthetic. in cal pyramidal neurons of the guinea-pig hippocampal slice, qx 314 bromide blocked both na+ dependent action potentials and the voltage-dependent, non-inactivating na+ conductance [1]. in xenopus laevis oocytes expressed trpv1 and trpv4 channels, qx 314 bromide (10, 30, and 60 mm) activated trpv1 channels, but not trpv4 channels. qx 314 bromide at lower concentrations (less than 1mm) potently inhibited capsaicin-evoked trpv1 currents with ic50 value of 8.0 μm. in trpv1-expressing tsa201 cells, qx 314 bromide induced transient increase in cytoplasmic ca2+ [2]. in large-diameter human drg neurons, flagellin/qx 314 bromide inhibited sodium currents [3].in three standard local anesthetic animal models, qx 314 bromide reversibly and concentration-dependently induced long-lasting local anesthesia with a slow onset [4]. intraplantar co-application of flagellin/qx 314 bromide inhibited mechanical allodynia after nerve injury, chemotherapy and diabetic neuropathy in a dose-dependent way. in naive and chemotherapy-treated mice, co-application of flagellin/qx 314 bromide selectively inhibited aβ-fiber conduction [3].

storage

Room temperature (desiccate)

References

[1]. connors bw, prince da. effects of local anesthetic qx 314 bromide on the membrane properties of hippocampal pyramidal neurons. j pharmacol exp ther, 1982, 220(3): 476-481.
[2]. rivera-acevedo re, pless sa, ahern ca, schwarz sk. the quaternary lidocaine derivative, qx 314 bromide, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. anesthesiology, 2011, 114(6): 1425-1434.
[3]. xu zz, kim yh, bang s, et al. inhibition of mechanical allodynia in neuropathic pain by tlr5-mediated a-fiber blockade. nat med, 2015, 21(11): 1326-1331.
[4]. lim tk, macleod ba, ries cr, et al. the quaternary lidocaine derivative, qx 314 bromide, produces long-lasting local anesthesia in animal models in vivo. anesthesiology, 2007, 107(2): 305-311.

N-ETHYLLIDOCAINE BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-ETHYLLIDOCAINE BROMIDE Suppliers

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24003-58-5, N-ETHYLLIDOCAINE BROMIDERelated Search:

2-[(2,6-DIMETHYLPHENYL)AMINO]-N,N,N-TRIETHYL-2-OXO-ETHANAMINIUM BROMIDE

N-ETHYLLIDOCAINE BROMIDE

[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium:bromide

QX 314 bromide,QX314 bromide

24003-58-5