N-ETHYLLIDOCAINE BROMIDE

Product Name: N-ETHYLLIDOCAINE BROMIDE
CAS No.: 24003-58-5
Chemical Name: N-ETHYLLIDOCAINE BROMIDE
Synonyms: N-ETHYLLIDOCAINE BROMIDE;QX 314 bromide,QX314 bromide;[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium:bromide;2-[(2,6-DIMETHYLPHENYL)AMINO]-N,N,N-TRIETHYL-2-OXO-ETHANAMINIUM BROMIDE
CBNumber: CB02463601
Molecular Formula: C16H27BrN2O
Formula Weight: 343.31
MOL File: 24003-58-5.mol

More

Less

N-ETHYLLIDOCAINE BROMIDE Property

Melting point:: 214-215 °C
storage temp.: Desiccate at RT
solubility: insoluble in EtOH; ≥10.5 mg/mL in H2O; ≥25.55 mg/mL in DMSO
form: crystalline solid
color: White
Water Solubility: Soluble to 100 mM in water

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: Q0118
Product name: QX 314 Bromide
Packaging: 100MG
Price: $102
Updated: 2025/07/31

Cayman Chemical

Product number: 10011032
Product name: QX-314 (bromide)
Purity: ≥98%
Packaging: 25mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 10011032
Product name: QX-314 (bromide)
Purity: ≥98%
Packaging: 50mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 10011032
Product name: QX-314 (bromide)
Purity: ≥98%
Packaging: 100mg
Price: $81
Updated: 2024/03/01

TRC

Product number: Q950000
Product name: QX314Bromide
Packaging: 100mg
Price: $75
Updated: 2021/12/16

More

Less

N-ETHYLLIDOCAINE BROMIDE Chemical Properties,Usage,Production

Uses

QX-314 bromide is a derivative of Lidocaine. It is a local anesthetic.

Biological Activity

qx 314 bromide is a positively charged, membrane-impermeable quaternary lidocaine derivative [1][2][3][4].qx 314 bromide is a local anesthetic. in cal pyramidal neurons of the guinea-pig hippocampal slice, qx 314 bromide blocked both na+ dependent action potentials and the voltage-dependent, non-inactivating na+ conductance [1]. in xenopus laevis oocytes expressed trpv1 and trpv4 channels, qx 314 bromide (10, 30, and 60 mm) activated trpv1 channels, but not trpv4 channels. qx 314 bromide at lower concentrations (less than 1mm) potently inhibited capsaicin-evoked trpv1 currents with ic50 value of 8.0 μm. in trpv1-expressing tsa201 cells, qx 314 bromide induced transient increase in cytoplasmic ca2+ [2]. in large-diameter human drg neurons, flagellin/qx 314 bromide inhibited sodium currents [3].in three standard local anesthetic animal models, qx 314 bromide reversibly and concentration-dependently induced long-lasting local anesthesia with a slow onset [4]. intraplantar co-application of flagellin/qx 314 bromide inhibited mechanical allodynia after nerve injury, chemotherapy and diabetic neuropathy in a dose-dependent way. in naive and chemotherapy-treated mice, co-application of flagellin/qx 314 bromide selectively inhibited aβ-fiber conduction [3].

in vivo

QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin^[2].

Animal Model:	Male Sprague-Dawley rats (250-290 g)^[2]
Dosage:	1.6 mg/kg
Administration:	Intracutaneous injection
Result:	Abolished responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.

storage

Room temperature (desiccate)

References

[1]. connors bw, prince da. effects of local anesthetic qx 314 bromide on the membrane properties of hippocampal pyramidal neurons. j pharmacol exp ther, 1982, 220(3): 476-481.
[2]. rivera-acevedo re, pless sa, ahern ca, schwarz sk. the quaternary lidocaine derivative, qx 314 bromide, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. anesthesiology, 2011, 114(6): 1425-1434.
[3]. xu zz, kim yh, bang s, et al. inhibition of mechanical allodynia in neuropathic pain by tlr5-mediated a-fiber blockade. nat med, 2015, 21(11): 1326-1331.
[4]. lim tk, macleod ba, ries cr, et al. the quaternary lidocaine derivative, qx 314 bromide, produces long-lasting local anesthesia in animal models in vivo. anesthesiology, 2007, 107(2): 305-311.

N-ETHYLLIDOCAINE BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-ETHYLLIDOCAINE BROMIDE Suppliers

China 33 India 1 United Kingdom 1 United States 6 USA 1 Global 42

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Yantai ShengKailun Chemical Technology Co., Ltd.

Tel: 13356901049
Fax: QQ：1025383091
Email: 3119594100@qq.com
Country: China
ProdList: 7964
Advantage: 55

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

cjbscvictory

Tel: 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10503
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4810
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

Shandong Mingde Biotechnology Co., Ltd

Tel: 15553348166
Email: m15553348166@163.com
Country: China
ProdList: 9967
Advantage: 58

Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
ProdList: 2742
Advantage: 58

Yantai Sheng Kai Lun Biological Products Co. , Ltd.

Tel: 13356901049
Email: mark@sklnchem.cn
Country: China
ProdList: 7997
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 5929
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Shaoguan Qicheng Biotechnology Co., Ltd

Tel: 18122215013
Email: 780229652@qq.com
Country: China
ProdList: 1291
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd

Tel: 025-58851090 17714375163
Email: 2881759498@qq.com
Country: China
ProdList: 13011
Advantage: 58

Shanghai Fine Biotech Co.，Ltd

Tel: 18221172427
Email: sale@fine-biotech.com
Country: China
ProdList: 2748
Advantage: 58

R&D Systems, Inc

Tel: 18003437475
Fax: 1-612-656-4400
Email: rdname@qq.com
Country: China
ProdList: 6960
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 33024
Advantage: 60

Qingdao Dexin Chemical Co., Ltd

Tel: +86-15553333686
Email: 15553333686@qq.com
Country: China
ProdList: 3113
Advantage: 58

Nantong HI-FUTURE Biology Co., Ltd.

Tel: +undefined18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 3135
Advantage: 58

Guangzhou Chuangze Biotechnology Co., Ltd.

Tel: 18312220236
Country: CHINA
ProdList: 178
Advantage: 58

Guangzhou Yunmei Technology Co., Ltd

Tel: 13826185148
Country: CHINA
ProdList: 113
Advantage: 58

Guangzhou Yansai Biological Products Co., Ltd.

Tel: 13710209565
Country: CHINA
ProdList: 122
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

24003-58-5, N-ETHYLLIDOCAINE BROMIDERelated Search:

2-[(2,6-DIMETHYLPHENYL)AMINO]-N,N,N-TRIETHYL-2-OXO-ETHANAMINIUM BROMIDE

N-ETHYLLIDOCAINE BROMIDE

[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium:bromide

QX 314 bromide,QX314 bromide

24003-58-5