4-BROMO-2-METHYLISOINDOLIN-1-ONE
- Product Name
- 4-BROMO-2-METHYLISOINDOLIN-1-ONE
- CAS No.
- 435273-55-5
- Chemical Name
- 4-BROMO-2-METHYLISOINDOLIN-1-ONE
- Synonyms
- 4-BROMO-2-METHYLISOINDOLIN-1-ONE;4-(1-Methoxypropan-2-yloxy)aniline;4-bromo-2-methyl-3H-isoindol-1-one;4-Bromo-2-methyl-2,3-dihydro-isoindol-1-one;4-Bromo-2,3-dihydro-2-methyl-1H-isoindol-1-one;4-broMo-2-Methyl-2,3-dihydro-1H-isoindol-1-one;1H-Isoindol-1-one,4-bromo-2,3-dihydro-2-methyl-;4-Bromo-2,3-dihydro-2-methyl-1H-isoindol-1-one, 4-Bromo-2,3-dihydro-2-methyl-1-oxo-1H-isoindole
- CBNumber
- CB02466213
- Molecular Formula
- C9H8BrNO
- Formula Weight
- 226.07
- MOL File
- 435273-55-5.mol
4-BROMO-2-METHYLISOINDOLIN-1-ONE Property
- Boiling point:
- 356.6±42.0 °C(Predicted)
- Density
- 1.589
- storage temp.
- 2-8°C
- pka
- -2.13±0.20(Predicted)
- form
- solid
- color
- Yellow
Safety
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B292895
- Product name
- 4-Bromo-2-methylisoindolin-1-one
- Packaging
- 50mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 4H48-9-W8
- Product name
- 4-Bromo-2-methylisoindolin-1-one
- Packaging
- 250mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- OR30752
- Product name
- 4-Bromo-2-methylisoindolin-1-one
- Packaging
- 250mg
- Price
- $102
- Updated
- 2021/12/16
- Product number
- 4H48-9-W8
- Product name
- 4-Bromo-2-methylisoindolin-1-one
- Packaging
- 1g
- Price
- $408
- Updated
- 2021/12/16
- Product number
- 188597
- Product name
- 4-Bromo-2-methylisoindolin-1-one
- Packaging
- 1g
- Price
- $526
- Updated
- 2021/12/16
4-BROMO-2-METHYLISOINDOLIN-1-ONE Chemical Properties,Usage,Production
Synthesis
74-89-5
337536-14-8
435273-55-5
Methyl 3-bromo-2-(bromomethyl)benzoate (5.27 g, 17 mmol) obtained in Step 2 was dissolved in 50 mL of tetrahydrofuran and 40% aqueous methylamine solution (7.5 mL, 86 mmol) was added. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was evaporated under reduced pressure. The resulting residue was diluted with water and extracted with ethyl acetate. The organic layers were combined, washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. After filtration, the solvent was removed by concentration under reduced pressure. The residue was purified by silica gel column chromatography to afford 4-bromo-2-methylisoindolin-1-one (3.36 g, 87% yield).1H NMR (300 MHz, CDCl3) δ 7.68 (d, 1H, J = 7.9 Hz), 7.53 (dd, 1H, J = 7.9, 0.9 Hz), 7.26 (t, 1H, J = 7.9 Hz), 7.26 (t, 1H, J = 7.9 Hz) 4.20 (s, 2H), 3.11 (s, 3H).
References
[1] Patent: WO2009/51417, 2009, A2. Location in patent: Page/Page column 13
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 11, p. 3036 - 3040
[3] Patent: WO2012/74951, 2012, A1. Location in patent: Page/Page column 36-37
4-BROMO-2-METHYLISOINDOLIN-1-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-BROMO-2-METHYLISOINDOLIN-1-ONE manufacturers
- Product
- 4-BROMO-2-METHYLISOINDOLIN-1-ONE 435273-55-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 819
- Release date
- 2019-09-02