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PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-

Product Name
PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-
CAS No.
845827-13-6
Chemical Name
PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-
Synonyms
3-Bromo-6-(difluoromethyl)pyridine;PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-;5-Bromo-2-(difluoromethyl)pyridine 95%;5-Bromo-alpha,alpha-difluoro-2-picoline
CBNumber
CB02468671
Molecular Formula
C6H4BrF2N
Formula Weight
208
MOL File
845827-13-6.mol
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PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)- Property

Melting point:
35-40℃
Boiling point:
206.6±35.0 °C(Predicted)
Density 
1.64
Flash point:
89°(192°F)
storage temp. 
2-8°C
form 
Solid
pka
-0.83±0.29(Predicted)
color 
White to yellow
InChI
InChI=1S/C6H4BrF2N/c7-4-1-2-5(6(8)9)10-3-4/h1-3,6H
InChIKey
QXLZRIGSWWQOLG-UHFFFAOYSA-N
SMILES
C1(C(F)F)=NC=C(Br)C=C1
CAS DataBase Reference
845827-13-6
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
2811
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
741299
Product name
5-Bromo-2-(difluoromethyl)pyridine
Purity
95%
Packaging
500mg
Price
$103
Updated
2023/06/20
TRC
Product number
B690258
Product name
5-Bromo-2-(difluoromethyl)pyridine
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
B690258
Product name
5-Bromo-2-(difluoromethyl)pyridine
Packaging
250mg
Price
$75
Updated
2021/12/16
TRC
Product number
B690258
Product name
5-Bromo-2-(difluoromethyl)pyridine
Packaging
1g
Price
$165
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0366839
Product name
5-BROMO-2-(DIFLUOROMETHYL)PYRIDINE
Purity
95.00%
Packaging
5MG
Price
$502.23
Updated
2021/12/16
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PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)- Chemical Properties,Usage,Production

Synthesis

31181-90-5

845827-13-6

General procedure for the synthesis of 5-bromo-2-difluoromethylpyridine from 5-bromo-2-pyridinecarboxaldehyde: To a cooled solution of 5-bromopyridine-2-carboxaldehyde (A) (7.0 g, 38 mmol) in dichloromethane (300 mL) was slowly added diethylaminosulfur trifluoride (DAST, 10.8 mL, 83 mmol) at -78 °C. The reaction mixture was gradually warmed to room temperature over a period of 6 h. The reaction was subsequently quenched by the slow addition of water. The reaction mixture was washed with saturated aqueous sodium bicarbonate solution and dried with anhydrous sodium sulfate. Concentration and purification by silica gel column chromatography (dichloromethane as eluent) afforded 5-bromo-2-difluoromethylpyridine (B) as brown crystals (5.3 g, 67% yield).1H NMR (300 MHz, CDCl3) δ 8.8 (s, 1H), 8.0 (d, 1H), 7.6 (d, 1H), 6.6 (t, 1H).

References

[1] Patent: US2012/302608, 2012, A1. Location in patent: Page/Page column 11
[2] Patent: WO2006/109729, 2006, A1. Location in patent: Page/Page column 168-169
[3] Patent: US2009/23782, 2009, A1. Location in patent: Page/Page column 13
[4] Patent: US2010/168178, 2010, A1. Location in patent: Page/Page column 11
[5] Patent: US2010/168177, 2010, A1. Location in patent: Page/Page column 11

PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)- Preparation Products And Raw materials

Raw materials

Preparation Products

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PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)- Suppliers

China 77 India 2 United Kingdom 1 United States 7 Global 87
Shanghai Helai Biotech Co. Ltd.
Tel
15721400568
Email
helaibiotech@163.com
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China
ProdList
155
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58
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
5000
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55
Santai Labs, Inc.
Tel
519-85601385
Fax
+86 519 8560 1389
Email
marketing@santailabs.com
Country
China
ProdList
891
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62
Shandong Xiya Chemical Co., Ltd
Tel
13355009207 13355009207
Fax
0539-6365991
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3007715519@qq.com
Country
China
ProdList
18729
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Wuhan ariel chemical Co., LTD.
Tel
18986259541
Fax
027-87840182
Email
sales@3stc.com
Country
China
ProdList
3755
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58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4999
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60
Shanghai potentpharm CO.,Ltd
Tel
13524892556
Fax
(86) 21 51969655， QQ： 263541193
Email
sales-cn@potentpharm.com
Country
China
ProdList
1011
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Cochemical Ltd.
Tel
029-86115547 17791676824
Fax
02151602123
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sales@cochemical.com
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China
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3014
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58
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
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product02@bidepharm.com
Country
China
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39967
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60
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
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sales@coolpharm.com
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China
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12346
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58
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View Lastest Price from PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)- manufacturers

Career Henan Chemical Co
Product
5-Bromo-2-(difluoromethyl)pyridine 845827-13-6
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-10
Career Henan Chemical Co
Product
5-Bromo-2-(difluoromethyl)pyridine 845827-13-6
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-09

845827-13-6, PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-Related Search:


  • PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-
  • 5-Bromo-alpha,alpha-difluoro-2-picoline
  • 3-Bromo-6-(difluoromethyl)pyridine
  • 5-Bromo-2-(difluoromethyl)pyridine 95%
  • 845827-13-6