ChemicalBook > CAS DataBase List > 4-METHYL-3,4-DIHYDROQUINOXALIN-2(1H)-ONE

4-METHYL-3,4-DIHYDROQUINOXALIN-2(1H)-ONE

Product Name: 4-METHYL-3,4-DIHYDROQUINOXALIN-2(1H)-ONE
CAS No.: 67074-63-9
Chemical Name: 4-METHYL-3,4-DIHYDROQUINOXALIN-2(1H)-ONE
Synonyms: 4-methyl-1,3-dihydroquinoxalin-2-one;4-Methyl-3,4-dihydroquinoxalin-2(1H);3,4-dihydro-4-methyl-2(1H)-Quinoxalinone;4-METHYL-3,4-DIHYDROQUINOXALIN-2(1H)-ONE;2(1H)-Quinoxalinone, 3,4-dihydro-4-methyl-
CBNumber: CB02469067
Molecular Formula: C9H10N2O
Formula Weight: 162.19
MOL File: 67074-63-9.mol

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4-METHYL-3,4-DIHYDROQUINOXALIN-2(1H)-ONE Property

storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 0305AC
Product name: 4-Methyl-3,4-dihydroquinoxalin-2(1H)-one
Packaging: 1g
Price: $451
Updated: 2021/12/16

Matrix Scientific

Product number: 133252
Product name: 4-Methyl-3,4-dihydroquinoxalin-2(1H)-one
Purity: 97%
Packaging: 5g
Price: $1440
Updated: 2021/12/16

Matrix Scientific

Product number: 133252
Product name: 4-Methyl-3,4-dihydroquinoxalin-2(1H)-one
Purity: 97%
Packaging: 10g
Price: $2160
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0150722
Product name: 4-METHYL-3,4-DIHYDROQUINOXALIN-2(1H)-ONE
Purity: 95.00%
Packaging: 5G
Price: $2656.5
Updated: 2021/12/16

Ambeed

Product number: A164445
Product name: 4-Methyl-3,4-dihydroquinoxalin-2(1H)-one
Purity: 97%
Packaging: 5g
Price: $694
Updated: 2021/12/16

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4-METHYL-3,4-DIHYDROQUINOXALIN-2(1H)-ONE Chemical Properties,Usage,Production

Synthesis

50-00-0

59564-59-9

67074-63-9

The general procedure for the synthesis of 4-methyl-3,4-dihydroquinoxalin-2(1H)-one from formaldehyde and 3,4-dihydroquinoxalin-2(1H)-one was as follows: sodium cyanoborohydride (425 mg, 6.76 mmol) was sequentially added to a methanol (3 mL) solution of 3,4-dihydroquinoxalin-2(1H)-one (500 mg, 3.378 mmol), paraformaldehyde (102 mg) and acetic acid (30 μL). The reaction mixture was stirred at room temperature for 4 hours. Subsequently, another portion of sodium cyanoborohydride (212 mg, 3.37 mmol), paraformaldehyde (51 mg) and concentrated hydrochloric acid (10 μL) was added to the reaction mixture. The reaction mixture was stirred at 50 °C for 5 h and then cooled to room temperature. The pH was adjusted to 8 with base and the solvent was evaporated under reduced pressure. The target product was extracted with ethyl acetate and washed with brine and dried over anhydrous sodium sulfate. After evaporation of the solvent under reduced pressure, 4-methyl-3,4-dihydroquinoxalin-2(1H)-one (537 mg, 98% yield) was obtained as a beige powder.LC-MS ESI m/z 163 [M + H]+.

References

[1] Patent: US2005/261244, 2005, A1. Location in patent: Page/Page column 53
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 22, p. 9275 - 9295
[3] Patent: CN106317027, 2017, A. Location in patent: Paragraph 0196; 0197; 0198

4-METHYL-3,4-DIHYDROQUINOXALIN-2(1H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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67074-63-9, 4-METHYL-3,4-DIHYDROQUINOXALIN-2(1H)-ONERelated Search:

4-METHYL-3,4-DIHYDROQUINOXALIN-2(1H)-ONE

3,4-dihydro-4-methyl-2(1H)-Quinoxalinone

4-Methyl-3,4-dihydroquinoxalin-2(1H)

4-methyl-1,3-dihydroquinoxalin-2-one

2(1H)-Quinoxalinone, 3,4-dihydro-4-methyl-

67074-63-9