ChemicalBook > CAS DataBase List > 2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE

2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE

Uses

Product Name: 2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE
CAS No.: 1035219-96-5
Chemical Name: 2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE
Synonyms: 2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H);2-brome-6,7-dihydrothiazole[5,4-C]pyridin-4(5H)-one;2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE;Thiazolo[5,4-c]pyridin-4(5H)-one, 2-bromo-6,7-dihydro-;2-Bromo-5,6,7,7a-tetrahydro-3aH-thiazolo[5,4-c]pyridin-4-one
CBNumber: CB02469072
Molecular Formula: C6H5BrN2OS
Formula Weight: 233.09
MOL File: 1035219-96-5.mol

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2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE Property

Boiling point:: 487.7±34.0 °C(Predicted)
Density: 1.825±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 12.76±0.20(Predicted)
Appearance: Light yellow to green yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: 0840AA
Product name: 2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one
Packaging: 100mg
Price: $284
Updated: 2021/12/16

Matrix Scientific

Product number: 093498
Product name: 2-Bromo-6,7-dihydrothiazolo-[5,4-c]pyridin-4(5H)-one
Purity: 95+%
Packaging: 250mg
Price: $738
Updated: 2021/12/16

Matrix Scientific

Product number: 093498
Product name: 2-Bromo-6,7-dihydrothiazolo-[5,4-c]pyridin-4(5H)-one
Purity: 95+%
Packaging: 1g
Price: $1647
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0103796
Product name: 2-BROMO-6,7-DIHYDROTHIAZOLO(5,4-C)PYRIDIN-4(5H)-ONE
Purity: 95.00%
Packaging: 5G
Price: $7276.5
Updated: 2021/12/16

Crysdot

Product number: CD11362123
Product name: 2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one
Purity: 95+%
Packaging: 5g
Price: $1961
Updated: 2021/12/16

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2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE Chemical Properties,Usage,Production

Uses

2-Bromo-6,7-dihydrothiazo[5,4-C]pyridine-4(5H)-one is a pyridine organic compound that can be used as an organic intermediate.

Synthesis

26493-11-8

1035219-96-5

The general procedure for the synthesis of 2-bromo-6,7-dihydrothiazolo[5,4-b]pyridin-4(5H)-ones using 2-amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-ones as starting material was as follows: intermediate 3 (8 g, 39.8 mmol), copper(II) bromide (10.43 g, 46.68 mmol) and 3-methyl-1- Nitrosoxybutane (6.8 g, 58.35 mmol) were dissolved in acetonitrile (100 mL) and the reaction was stirred at room temperature for 1.5 hours. Upon completion of the reaction, the solvent was removed by vacuum evaporation. The resulting residue was dissolved in ethyl acetate and washed with water. The organic layer was separated, dried with anhydrous sodium sulfate, filtered and the solvent was evaporated in vacuum to give Intermediate 4 (5 g, 55% yield), which could be used in subsequent steps without further purification.

References

[1] Patent: WO2011/73339, 2011, A1. Location in patent: Page/Page column 43
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 14, p. 4037 - 4043
[3] Patent: WO2015/101928, 2015, A1. Location in patent: Page/Page column 66; 67

2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE Suppliers

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1035219-96-5, 2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONERelated Search:

2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE

2-brome-6,7-dihydrothiazole[5,4-C]pyridin-4(5H)-one

2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)

Thiazolo[5,4-c]pyridin-4(5H)-one, 2-bromo-6,7-dihydro-

2-Bromo-5,6,7,7a-tetrahydro-3aH-thiazolo[5,4-c]pyridin-4-one

1035219-96-5

C6H5BrN2OS