2,5-Dichloroquinoxaline
- Product Name
- 2,5-Dichloroquinoxaline
- CAS No.
- 55687-05-3
- Chemical Name
- 2,5-Dichloroquinoxaline
- Synonyms
- 2,5-Dichloroquinoxaline;Quinoxaline, 2,5-dichloro-
- CBNumber
- CB02471206
- Molecular Formula
- C8H4Cl2N2
- Formula Weight
- 199.04
- MOL File
- 55687-05-3.mol
2,5-Dichloroquinoxaline Property
- Melting point:
- 295 °C (approx, decomp)
- Boiling point:
- 290.5±35.0 °C(Predicted)
- Density
- 1.486±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- -3.34±0.30(Predicted)
- color
- Orange to Dark Brown
Safety
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- D438243
- Product name
- 2,5-Dichloroquinoxaline
- Packaging
- 500mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- OR927312
- Product name
- 2,5-Dichloroquinoxaline
- Purity
- 95%
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- Z4882
- Product name
- 2,5-Dichloroquinoxaline
- Packaging
- 1g
- Price
- $244
- Updated
- 2021/12/16
- Product number
- 3H32-5-VB
- Product name
- 2,5-Dichloroquinoxaline
- Purity
- 95%
- Packaging
- 250mg
- Price
- $256
- Updated
- 2021/12/16
- Product number
- OR927312
- Product name
- 2,5-Dichloroquinoxaline
- Purity
- 95%
- Packaging
- 1g
- Price
- $345
- Updated
- 2021/12/16
2,5-Dichloroquinoxaline Chemical Properties,Usage,Production
Uses
2,5-Dichloroquinoxaline is used in the synthetic preparation of chloroquinoxalines from (chloro)nitroanilines in synthesis of (chloroquinoxalinyloxy)phenoxypropionic acid analogs as antitumor agents.
Definition
ChEBI: 2,5-Dichloroquinoxaline is a quinoxaline derivative.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 44, p. 1758, 2001 DOI: 10.1021/jm0005149
Synthesis
55687-19-9
55687-05-3
Step 3: 5-chloro-2-hydroxyquinoxaline (0.60 g, 3.32 mmol) was mixed with phosphorus trichloride (10 mL, 109 mmol), heated to 90 °C and maintained for 3 hours. Upon completion of the reaction, the mixture was slowly poured into ice water and subsequently extracted with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give a dark brown solid crude product. The crude product was purified by silica gel column chromatography using 0-30% ethyl acetate/hexane gradient elution to give 2,5-dichloroquinoxaline as a white solid (210 mg, 32% yield).
References
[1] Patent: US2010/120778, 2010, A1. Location in patent: Page/Page column 29
[2] Journal of the American Chemical Society, 1949, vol. 71, p. 6,7
[3] Journal of Medicinal Chemistry, 1981, vol. 24, # 1, p. 93 - 101
[4] Patent: DE2433397, 1974,
2,5-Dichloroquinoxaline Preparation Products And Raw materials
Raw materials
Preparation Products
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